August 2022 "WELCOME 4GPCRnet meeting bringing together four of the biggest GPCR networks in Europe for a joint meeting in Leipzig. Four of the biggest European networks on GPCR research (COST Actions Adher’n Rise and ERNEST plus DFG-funded SFB1423 and FOR2372) have joined forces to organize an international meeting, which will take place from 26th-29th September 2022 in the beautiful city of Leipzig in Germany. We aim to connect renowned international experts of the field with early career ‘rising stars’. The event will take place in the heart of Leipzig, which offers a colorful mixture of culture and vivid social life." Read more at the source #DrGPCR #GPCR #IndustryNews

Discovery on Target (DOT) highlights advances in current and emerging “hot” targets and technologies, as well

August 2022 RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany. Hybrid meeting. "Dear Sir or Madam, dear Colleagues, It gives me great pleasure to announce the fourth hybrid symposium on regulatory autoantibodies targeting G-protein-coupled receptors (GPCRs) in Lübeck. GPCRs are involved in a variety of physiological and pathophysiological processes. So far, numerous therapeutics targeting GPCRs have been developed, with a focus on small molecules and monoclonal antibodies for the treatment of cancer, infections, metabolic disorders or inflammatory diseases. Recently, functional autoantibodies targeting GPCRs have been associated with various disease-specific manifestations, highlighting a potential new area for therapeutic intervention. Therefore, the aim of this symposium is to bring together the current knowledge on the role of autoantibodies targeting GPCRs in various diseases, such as cardiovascular diseases, renal diseases, autoimmune diseases such as systemic sclerosis or systemic lupus erythematosus. In addition, one aim is to bring together the mode of action of autoantibodies in immune regulation and pathogenesis." Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "We are happy to announce you our 2nd IRN i-GPCRnet meeting that will be held at the University of Wurzburg (Germany) from september 30th to october 1rst." Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics optimized approach of combining the data derived from steered molecular dynamics simulations and the Bell-Evans

that the ligation of SDF-1 to CXCR4 initiates several intracellular signaling pathways, regulating cell proliferation, survival, chemotaxis, migration, angiogenesis, adhesion, as well as bone marrow (BM)- resident cells homing and mobilization. Additionally, CXCR4 is expressed by tumor cells in blood malignancies and solid tumors."

Al 2017) and its activation promotes migration and angiogenesis (Kim S. et. al 2015). In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and migration in long-term stimulus experiments (Kalbe B. et al. 2017). ) and the sandalore-activated receptor OR2AT4 shown to promote human keratinocyte proliferation and migration The chimeric antigen receptor T cell therapy could also be a way to target tumor cells expressing ectopic

the synovium "The rheumatoid arthritis (RA) inflammatory process occurs in the joints where immune cells as to perform a functional migration assay in response to GPR15L. synovial fluid and peripheral blood were analyzed for CD45+CD3+CD4+GPR15+ and CD45+CD3+CD8+GPR15+ T cell Migration assays were performed using PBMCs isolated from these individuals in response to the synthetic GPR15 and GPR15L are present in the synovial tissue of RA patients and GPR15L promotes migration of PBMCs

the direct role of fentanyl on cancer, little is known on the effect of fentanyl on ovarian cancer cells Methods Proliferation, migration and apoptosis assays were performed in ovarian cancer cells after fentanyl

March 2022 "Geneva, Switzerland, March 7, 2022 – Addex Therapeutics (SIX: ADXN, Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, announced today that it will issue its full-year 2021 financial results on Thursday, March 10, 2022. Tim Dyer, CEO, Roger Mills, CMO and Robert Lütjens, Head of Discovery Biology, will provide a business update and review its pipeline during a teleconference and webcast for investors, analysts and media at 16:00 CET (15:00 GMT / 10:00 EST / 07:00 PST) the same day. " Read more at the source #DrGPCR #GPCR #IndustryNews

ERK signaling, tightly regulated through feedback mechanisms and spatial localisation within the cell , is a crucial determinant of cellular responses such as proliferation, differentiation, migration, survival Cell Receptor-Mediated Gene Expression. Cells, 10(10), 2509. Volmat, V., & Pouysségur, J. (2001). Biology of the Cell, 93(1‐2), 71-79. Wei, H., Ahn, S., Shenoy, S. K., Karnik, S.

activating properties of human salivary histatin 1 "Human salivary histatin 1 (Hst1) exhibits a series of cell-activating properties, such as promoting cell spreading, migration, and metabolic activity. We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1. The inhibitors of GPCR, ERK1/2, phagocytosis, and clathrin-mediated endocytosis (CME) as well as siRNA reduced the uptake, which was accompanied by the nullification of the promoting effect of F-Hst1 on cell

website GPCR Events, Meetings, and Webinars November 25 - 26, 2024 | 6th International Conference on Stem Cell 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell GPCRs in Oncology and Immunology Gallein, G protein βγ subunits inhibitor, suppresses the TGF-α-induced migration of hepatocellular carcinoma cells via inhibition of the c-Jun N-terminal kinase Methods & Updates in

Human cells express over 800 G-protein-coupled receptors (GPCRs) to facilitate communication with the Capturing the dynamics of GPCR activation has always been a challenge because G protein activation in cells As GTP stabilizes and migrates towards the P loop, it causes the TCAT motif to shift, a key movement

subtype 1 protein (TRPA1) signaling pathways, thereby regulating proliferation, inflammation, adhesion, migration Several recent studies have demonstrated that TGR5 exerts inconsistent effects in different cancer cells

via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive retinalganglion cells GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment. GPCR Research Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells Expansion To Enable Site-Specific Bioorthogonal Labeling of Functional G Protein-Coupled Receptors in Live Cells phase I clinical study in patients with advanced, recurrent or metastatic solid tumors: the EPRAD study Call

and Clinical Pharmacology GPCR Jobs NEW GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell Long-Term Outcomes in Patients With Multiple Myeloma and Lymphoma Undergoing Chimeric Antigen Receptor T-Cell RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration Methods & Updates in GPCR Research Calcineurin-fusion facilitates cryo-EM structure

therapeutically exploit GPCRs (Physiology’s ‘Swiss Army Knife’) vast repertoire of ways to control cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell Activation and Signaling Diverse pathways in GPCR-mediated activation of Ca2+ mobilization in HEK293 cells by sphingosine kinase-1 GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract Intracellular

of the Year at the Citeline Japan Awards 2024 GPCR therapies: Eight promising biotechs hacking the cell Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell Approaches Altered PLCβ/IP3/Ca2+ Signaling Pathway Activated by GPRCs in Olfactory Neuronal Precursor Cells ) The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells

GPCR Activation and Signaling Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis again: the lysophosphatidic acid-CCN axis in signal transduction NPFF stimulates human ovarian cancer cell ERK1/2 signaling CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration Global Healthcare Conference CEO Raymond Stevens to Speak at STAT Future Summit on Obesity Therapeutics Call

Basic and Clinical Pharmacology GPCR Jobs GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell somatostatin receptor subtypes in rat pituitary Synthetic GPCRs for programmable sensing and control of cell virtual screening, molecular docking and dynamics simulation studies GPCRs in Neuroscience Neuronal cell Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma after CAR T-cell

., 1950 ), also called Duffy-antigen/receptor for chemokines, or DARC ( Novitzky-Basso and Rot, 2012 Erythrocytes are terminally differentiated anuclear cells with no transcription and limited translation Additionally, ACKR1 expression characterizes venular endothelial cells (ECs) ( Pruenster et al., 2009 This well-established, distinctive pattern of cell expression has been directly challenged by a publication and ECs, suggesting that macrophage ACKR1 engages its non-cognate ligand CD82 on hematopoietic stem cells

Front Cell Dev Biol, 2021. 9: p. 611443. 3.      ., Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design.  Cell, 2020. 182(3): p. 770-785.e16. 4.      Galés, C., et al., Real-time monitoring of receptor and G-protein interactions in living cells.  Goyet, E., et al., Fast and high resolution single-cell BRET imaging. 

September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different of the cytoskeleton and lipid microdomains in controlling signalling compartmentalization during T cell Here, we discuss mechanisms responsible for signalling amplification and compartmentalization in T cell

Congratulations to the GPCR Therapeutics team for their publication on improving hematopoietic stem cell Activation and Signaling The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function GPCR Binders, Drugs, and more GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization when combined with propranolol Discovery

Monserrat Avila-Zozaya , our incredible contributor, for her fantastic article on Profiling Immune Cell the science Lundbeck signs $2.5B check for Longboard, seeing blockbuster potential in epilepsy med Call Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell receptors GPCRs in Cardiology, Endocrinology, and Taste Latrophilin-2 Deletion in Cardiomyocyte Disrupts Cell

pathway GPCR Screening Reveals that the Metabolite Receptor HCAR3 Regulates Epithelial Proliferation, Migration regulates the expression and alternative splicing of genes associated with aphasia-related diseases in PC12 cells Scientist Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell

understood in cardiomyocytes and vascular smooth muscle cells (VSMCs). In VSMCs, stimulation of GPCRs also modulates contractile and cell growth phenotypes. on key signaling events involved in the activation and differentiation of these cells. signaling events driving the fibrotic response and the communications between fibroblasts and other cells Finally, we explore what such connections between the cell surface and nuclear GPCR signaling might mean