Let's explore the newest developments in GPCR research and community news together! Monserrat Avila-Zozaya , our incredible contributor, for her fantastic article on Profiling Immune Cell Act now to become a part of our prestigious learning community! Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell

Front Cell Dev Biol, 2021. 9: p. 611443. 3.      Cell, 2020. 182(3): p. 770-785.e16. 4.      Galés, C., et al., Real-time monitoring of receptor and G-protein interactions in living cells.  Nature Communications, 2016. 7(1): p. 12178. 11.    Strungs, E.G., L.M. Luttrell, and M.H. Goyet, E., et al., Fast and high resolution single-cell BRET imaging. 

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging allows cells to continuously migrate by remaining responsive to chemokines, it dampens the , and CCR5 switch purely to scavenging (D'Amico G. et al. 2000), becoming incapable of promoting cell migration, a phenomenon which is likely to be mediated by changes in the cell motility machinery with

understood in cardiomyocytes and vascular smooth muscle cells (VSMCs). In VSMCs, stimulation of GPCRs also modulates contractile and cell growth phenotypes. on key signaling events involved in the activation and differentiation of these cells. We also review the hierarchy of signaling events driving the fibrotic response and the communications between fibroblasts and other cells in the heart.

., 1950 ), also called Duffy-antigen/receptor for chemokines, or DARC ( Novitzky-Basso and Rot, 2012 Erythrocytes are terminally differentiated anuclear cells with no transcription and limited translation Additionally, ACKR1 expression characterizes venular endothelial cells (ECs) ( Pruenster et al., 2009 This well-established, distinctive pattern of cell expression has been directly challenged by a publication and ECs, suggesting that macrophage ACKR1 engages its non-cognate ligand CD82 on hematopoietic stem cells

express multiple ORs, tumor cells associated with the nervous system express a single OR gene type ( proliferation via activation by β-ionone which initiates prostate cancer cell cycle arrest (Jones S. In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and identified ligands being often synthetic compounds, there has been a growing interest from the scientific community The chimeric antigen receptor T cell therapy could also be a way to target tumor cells expressing ectopic

September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different of the cytoskeleton and lipid microdomains in controlling signalling compartmentalization during T cell Here, we discuss mechanisms responsible for signalling amplification and compartmentalization in T cell

Congratulations to the GPCR Therapeutics team for their publication on improving hematopoietic stem cell Activation and Signaling The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function GPCR Binders, Drugs, and more GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization when combined with propranolol Discovery

GPCR Ecosystem and our community. The classes will be online Thursdays from 10 am EST. for disease therapy GPCRs in Cardiology, Endocrinology, and Taste Transcriptomic profiling highlights cell Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian cancer cells of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells Deuteration as a General Strategy to Enhance Azobenzene-Based Photopharmacology Optical Control of Cell-Surface

Join the global GPCR community and share your research—submit your abstract using this form. Oncology and Immunology Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 laboratory and point-of-use settings Quantitative proteomics reveals CLR interactome in primary human cells Exploiting Cell-Based Assays to Accelerate Drug Development for G Protein-Coupled Receptors TOR signaling

Information exchange and interpretation is essential in biology and understanding how cells integrate of information-coding molecules into complex orchestrated responses is a major challenge for modern cell In complex organisms, cell to cell communication occurs mostly through neurotransmitters and hormones are responsible for signal recognition at the membrane level and information transduction inside the cell the formation of GPCRs higher order oligomers provides the structural basis for organizing distinct cell

., for their study on Cell swelling enhances ligand-driven β-adrenergic signaling ✨ Reserve Your seat Carterra Ultra™ ushers in a new frontier in fragment and small molecule drug discovery Is the pharma community This technique for studying cell receptors could have sweeping implications for drug development DeepCure , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based plate homeostasis through IHH Signaling GPCR Activation and Signaling Illuminating GPCR trafficking Cell

We selected the adenosine receptor 2B (A2BAR), specifically expressed in cancer cell lines compared with stromal cells, to explore the use of fluorescent ligands that can be used for target visualization. Fluorescent probes allowed semi-quantitative receptor mapping in living cells and validated the specific expression of A2BAR in CRC cell lines. a potential pharmacological tool in CRC, using selective antagonists, finding a reduction in tumor cell

GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their stimuli to impact cell physiology. considerable focus has been placed on the ability of these therapeutics to modulate diseases by acting at cell The ability of these receptorsomes (often in the absence of typical cell surface ligands) to control

ERK signaling, tightly regulated through feedback mechanisms and spatial localisation within the cell Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth, Inflammation, Chondrocyte and Bone Cell Receptor-Mediated Gene Expression. Cells, 10(10), 2509. Volmat, V., & Pouysségur, J. (2001). Biology of the Cell, 93(1‐2), 71-79. Wei, H., Ahn, S., Shenoy, S. K., Karnik, S.

RGS4 is expressed in various immune cells, including T cells and B cells, and has been shown to modulate immune cell activation and cytokine production. to T cell activation[6]. Cell, 1997. 89(2): p. 251-61. https://pubmed.ncbi.nlm.nih.gov/9108480/ 2. Cell, 2021. 184(4): p. 931-942.e18. https://pubmed.ncbi.nlm.nih.gov/33571431/ 6.

as in human melanoma cells either expressing (A7) or lacking (M2) FLNA. First, we observed the formation of endogenous SST5 homo-dimers in GH3, A7, and M2 cells. SST2 and SST5 can also form endogenous hetero-dimers in these cells. robust receptor internalization at shorter times than in A7 cells. In conclusion, we demonstrated that in GH3 cells SST2 and SST5 can form both homo- and hetero-dimers

product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell Specifically, previous research has identified mechanistically distinct and cell type–specific roles for C3aR in regulating innate immune cell inflammatory state, antimicrobial killing capacity, and metabolism of C3a has been relegated to the serum; however, recent studies have provided evidence that various cell Thus, this review will cover specific roles of C3aR in driving cell type–specific and tissue specific

2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in Cell Membranes and Living Cells "Conformational biosensors to monitor the activation state of G protein-coupled (H3R) biosensor that allowed the detection of both (partial) agonism and inverse agonism on living cells In the current study, we have further characterized this H3R biosensor on intact cells by monitoring binding assays that in addition can also detect ligand efficacies with comparable values as the intact cell

this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement in cell THP-1 cells were activated and differentiated into either M1 or M2 macrophages. Cell migration was detected by the Boyden chamber migration assay, performed on macrophages derived from both the THP-1 cell line and human peripheral blood monocytes."

September 2022 "Sound is converted by hair cells in the cochlea into electrical signals, which are transmitted Frizzleds and Lgrs are dominant GPCRs that regulate stem cell self-renew abilities. Frizzleds and Celsrs have been demonstrated to play core roles in the modulation of cochlear planar cell review the key findings of GPCR in the cochlea and discuss the role of GPCR in the cochlea, such as stem cell

Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells. Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells Single-cell transcriptome analysis of NEUROG3+ cells during pancreatic endocrine differentiation with Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8), are expressed in a variety of cells including, leukocytes, fibroblasts, endothelial cells, and smooth muscle cells. of the ligand, its concentration, and the binding sites with the receptor, levels of the receptor, cell

chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8), are expressed in a variety of cells including, leukocytes, fibroblasts, endothelial cells, and smooth muscle cells. of the ligand, its concentration, and the binding sites with the receptor, levels of the receptor, cell

CPE-binding studies demonstrated saturable, high-affinity binding to 5-HTR1E in stably transfected HEK293 cells Treatment of 5-HTR1E stable cells with NF-α1/CPE increased pERK 1/2 and pCREB levels which prevented Cell survival assay in β-arrestin Knockout HEK293 cells showed that the NF-α1/CPE-5-HTR1E-mediated protection Immunofluorescence studies showed 5-HTR1E and NF-α1/CPE are highly expressed and co-localized on cell CPE-mediated protection of these neurons against oxidative stress and glutamate neurotoxicity-induced cell

If you want to share your work with our community, please don’t hesitate to fill out this form. neurological and psychiatric disorders: An in silico approach Opioid modulation of prefrontal cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation progression in MCF-7 cells Methods & Updates in GPCR Research Cryo-electron microscopy for GPCR research Illinois Septerna divulges new TSHR antagonists for hyperthyroidism Unlocking the Secrets of Cellular Communication

Cardiology, Endocrinology, and Taste Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype Mesenchymal stromal cell secretory molecules improve the functional survival pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell Program Receives €4 Million Grant Confo Therapeutics Appoints Stephen Dowd As Chief Business Officer Call Technician Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals Postdoc In Cell

Stimulation of AVPR2 with a selective agonist desmopressin promoted CRPC cell proliferation through cAMP In contrast, blocking AVPR2 with a selective FDA-approved antagonist, tolvaptan, reduced cell growth. Combinatorial use of AVPR1A and AVPR2 antagonists promoted apoptosis synergistically in CRPC cells. Furthermore, we found that castration-resistant cells produced AVP, the endogenous ligand for arginine vasopressin receptors, and knockout of AVP in CRPC cells significantly reduced proliferation suggesting