signaling pathway has captured an increasing amount of attention because of its involvement in various diseases , such as idiopathic pulmonary fibrosis, cancers, cardiovascular diseases and neuropathic pain, making development targeting LPA receptors to modulate LPA signaling and their therapeutic potential in various diseases

This high-resolution mapping can confirm the protein’s role in disease pathology and highlight allosteric Resistance A significant challenge in drug development, particularly in the treatment of infectious diseases systems, including multicellular organisms and human cells, to better mimic physiological conditions and disease

Repurposing Vaptans "Men with advanced prostate cancer are treated by androgen deprivation therapy but the disease cancer patient sample data revealed that coexpression of AVPR1A and AVPR2 is highly correlated with disease

August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (

tyrosine kinase IGF1R and its associated GPCRs are co-regulated by the noncoding RNA NEAT1 in Alzheimer's disease characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease assays Generation of a deep mouse brain spectral library for transmembrane proteome profiling in mental disease

global biopharmaceutical company developing novel oral therapeutics to treat a wide range of chronic diseases

receptor (GPCR) GPR35 is involved in oncogenic signaling, bacterial infections, and inflammatory bowel disease transducer interactions and allow for mechanism-based therapies against, for example, inflammatory bowel disease

CCXI), a biopharmaceutical company focused on orally administered therapeutics to treat autoimmune diseases

therapeutic strategies aimed at targeting specific phosphorylation events to modulate G protein signaling in disease our understanding of cellular signaling dynamics and open new avenues for therapeutic intervention in diseases

chemokine receptor system is implicated in a wide range of inflammatory, autoimmune and infectious diseases a single receptor as patients cannot be stratified into CKRs specific subpopulations for a specific disease the majority of potential therapeutic applications are situated in the area of chronic inflammatory disease

UdM”), to discover novel small molecules targeting G-Protein Coupled Receptors (GPCRs) in a metabolic disease

outstanding study on Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease challenges Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease Chemokine CXCL13-CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases

GPCRs, including β2AR, play key roles in various conditions, such as asthma, cardiovascular diseases, These insights have the potential to advance the treatment of various diseases involving GPCR signalling

D2LR, D3R, and D4R, vasopressin V1AR, and serotonin 5-HT1AR are noted in various neurodegenerative diseases antagonism, kurarinone might be a potential compound that can alleviate clinical symptoms of Parkinson's disease

NETs were also detected in thrombotic lesions in several disease backgrounds, pointing towards a role between platelets and NETs and the potential of this alliance to influence the course of inflammatory diseases

for their work on GPCR gene variants and human genetic disease Ilana Kotliar , Thomas Sakmar , et al. Intelligence Reviews, GPCRs, and more G protein-coupled receptor (GPCR) gene variants and human genetic disease

novel mechanism providing diversity to receptor function and play important roles in physiology and disease

regulation of B2R, which shed light on structure-based drug design for the treatment of B2R-related diseases

fundraising gives us the means to achieve our ambitions: to become a leading player in the field of brain diseases

advanced our understanding of rod outer segment (ROS) morphology and the pathological basis of retinal diseases

for developing therapeutic agents that target specific receptor dimer states to modulate signaling in diseases Perreault, M.L., et al., Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease

Promising preclinical data supports the applicability of CB2 activation in autoimmune and inflammatory diseases

Promising preclinical data support the applicability of CB2 activation in autoimmune and inflammatory diseases

significance in GPCR internalization dynamics, internalization routes, postinternalization fates, and related diseases

Commercialization of Voyager’s GBA1 Program and Other Next-Generation Gene Therapies for Neurological Diseases Manager Director of Molecular Pharmacology, Discovery Biology Staff Scientist/Senior Staff Scientist, Disease

The levels of chemerin in circulation are correlated with certain disease conditions, such as patients

Heptares and Lilly Enter Multi-target Collaboration and License Agreement in Diabetes and Metabolic Diseases Trial of INV-202, an Oral, Peripherally-acting CB1 Inverse Agonist, in Patients with Diabetic Kidney Disease

focused on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases