< GPCR News < GPCRs in Oncology and Immunology The Effect of Cancer-Associated Mutations on Ligand Binding regulating mood, appetite, and reproductive behavior, it has been identified as a potential target for cancer In this study, we aimed to investigate the effects of cancer patient-derived 5-HT2C receptor mutations sequencing data from the Genomic Data Commons data portal (GDC), we selected 12 mutations from multiple cancer P van Westen, Erik H J Danen, Laura H Heitman Tags 5-HT(2C) receptor , G protein-coupled receptor , cancer

GPCRs in Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer Increased VIPR2 mRNA expression and/or VIPR2 gene copy number has been documented in several cancers However, the pathophysiological role of increased VIPR2 in the proliferation of breast cancer cells remains In this study, we found that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer Increased VIPR2 also exacerbated intraperitoneal proliferation of breast cancer MDA-MB-231 cells in a

and Immunology [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer 7, 2023 Abstract "A3 adenosine receptor is an interesting target that showed controversial roles in cancer Compound 20 has been tested on both A3 adenosine receptor positive cancer cell lines (CHO-A3AR transfected , THP1 and HCCT26) and in A3 negative cancer cell lines, showing no effect on the latter and a proliferative Karl-Norbert Klotz , Sabrina Pacor , Stefano Moro , Giampiero Spalluto Tags A3 adenosine receptor , Cancer

power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity, cancer Authors Donato Inverso, Carlotta Tacconi, Serena Ranucci, Marco De Giovanni Tags Angiogenesis , Cancer

< GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer June 12, 2023 Abstract "Immune checkpoint blockade (ICB) targeting PD-1 and CTLA-4 has revolutionized cancer However, many cancers do not respond to ICB, prompting the search for additional strategies to achieve we cross-integrated large singe-cell RNA-sequencing datasets from CD8+ T cells covering 19 distinct cancer

and Immunology Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer prior study, we reported the synergistic cytotoxic effects of gemcitabine and trabectedin on pancreatic cancer analysis was performed, and a system pharmacodynamics model (SPD) was developed to capture pancreatic cancer Straubinger , William J Jusko Tags Systems Pharmacodynamic , drug combination , gemcitabine , pancreatic cancer

guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer β1-adrenergic receptor (β1AR) are G protein-coupled receptors (GPCR) that are implicated in breast cancer MCF7 breast cancer cells express GPR30, β1AR, MAGUKs, and AKAP5 in the plasma membrane, and co-immunoprecipitation Stephen Serafin , Tobias Schmidt , Björn Olde , Kathleen M Caron , L M Fredrik Leeb-Lundberg Tags Breast cancer

< GPCR News < GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis Published date September 21, 2024 Abstract "Colorectal cancer Further tests showed that GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression

protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer Published date September 21, 2023 Abstract "Objectives: Lung cancer is a major public health concern and represents the most common cause of cancer-related death worldwide. protein-coupled receptor 37 (GPR37) exhibits unknown functions in tumors, particularly in non-small-cell lung cancer

< GPCR News < GPCRs in Oncology and Immunology Colorectal cancer incidence trends in Golestan, Iran: the effects of factors including age, birth year (cohort) and diagnosis year (period) on colorectal cancer Methods: We obtained data on incidence cases of CRC from the Golestan Population-based Cancer Registry Weiderpass , Gholamreza Roshandel , Freddie Bray , Reza Malekzadeh Tags Age-Period-Cohort model , Colorectal Cancer

Here, we evaluated adding sorafenib to cladribine, high-dose cytarabine, granulocyte colony-stimulating Authors Chenshen Huang , Fengshuo Zhu , Hao Zhang , Ning Wang , Qi Huang Tags Cancer , Machine learning

antihistamines: A clinical trial is needed Published date November 15, 2024 Abstract "Survival in pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) at just 5 months is the worst of all cancers. It is predicted to become the second highest cause of cancer deaths worldwide this decade and unlike most cancers, there has been little progress in improving survival in PDAC. Numerous studies including molecular and mechanistic studies, cancer biology studies and retrospective

A large component of his work is centered around dysregulated signaling in cancer and the development of novel mechanism-based cancer therapies. Silvio Gutkind on the web Gutkind Lab – UC San Diego Moores Cancer Center Gutkind Lab publications More J Silvio Gutkind on LinkedIn Gutkind Lab on Twitter UCSD Moores Cancer Center Dr.

Therefore, GPCRs are potential targets for cancer immunotherapy. Finally, we review the progress of clinical trials of GPCR-targeted drugs for cancer treatment, which GPCRs may shed light on the mechanisms underlying tumor progression and provide a novel perspective on cancer Authors Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy

Oncology and Immunology Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer adenocarcinoma (PDAC) remains an aggressive disease that is expected to become the second cause of cancer siRNA-mediated knockdown of YES1, and transfection of epitogue-tagged YAP mutants in PANC-1 and Mia PaCa-2 cancer

Published date November 15, 2023 Abstract "Epstein-Barr virus (EBV) is the oncogenic driver of multiple cancers However, the underlying mechanism of virus-cancer immunological interaction during disease pathogenesis as immune-inflamed, -deficient, and -desert phenotypes, in association with different setpoints of cancer-immunity expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated virus-cancer GPCR-mediated malignant progression and translated sensors of viral molecules into EBV-specific anti-cancer

In this episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and J Silvio Gutkind on LinkedIn Gutkind Lab – UC San Diego Moores Cancer Center Gutkind Lab publications Gutkind Lab on Pubmed Gutkind Lab on Twitter UCSD Moores Cancer Center Dr.

RGS5 expression in the triple-negative (TNBCs) and non-triple-negative breast cancers (Non-TNBCs) was The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs In contrast, in the context of breast cancer tissues, the role of RGS5 was completely disrupted. RGS5 expression was increased in the triple-negative breast cancer (TNBC) tissues and in the tumor blood Dan-Dan Zhang , Xiao-Fu Huang , Yu Song , Wen-Di Zhang , Rui-Juan Guo , Han Li , Mei Han Tags Breast cancer

CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers Likewise, lysophosphatidic acid receptor 1 (LPA1) is implicated in cancer cell proliferation and migration We observed that CXCR4 forms heteromers with LPA1 in recombinant HEK293A cells and the human breast cancer LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express Moreover, our findings propose a therapeutic potential in combined CXCR4 and LPA1 inhibitors for cancer

University of Utah School of Medicine in Salt Lake City, UT, and an investigator with the Huntsman Cancer focuses on Smoothened and other class F GPCRs which play essential roles in embryonic development and in cancer Ben studied developmental and cancer signaling as a postdoctoral fellow with Philip Beachy at Stanford

GPCRs in Oncology and Immunology Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer Using a model of human adrenocortical cancer cells, here we established that activation of the GPCR OXER1

signaling 2 (RGS2), a member of the R4 family of RGS proteins, is overexpressed in many solid breast cancers , and its levels in prostate cancer significantly correlate with the metastatic stage and poor prognosis All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays. In addition, AJ-3 inhibited the migration of LNCaP prostate cancer cells in wound healing assays.

Institute for Diabetes and Cancer, Helmholtz Centre Munich, Germany, 2. " About Anastasia Georgiadi "Head of Junior Group Endocrine Pharmacology, Institute of Diabetes and Cancer Professional Background Since 2021 Group Leader, Institute for Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2018 - 2021 Project Team Leader, Institute for Diabetes and Cancer, Helmholtz Diabetes Munich 2015 - 2018 Postdoctoral fellow, Department of Adipose Tissue Biology, Institute for Diabetes and Cancer

Potent inhibitors of ADO signaling are currently being tested in cancer patients, including in randomized immunologist, Dr Stagg is recognized for having identified the adenosine-producing enzyme CD73 as a new cancer John Stagg on the web University of Montréal Québec Cancer Consortium The University of Montreal Hospital

The primary endpoint was severe (grade ≥3) infection incidence. The incidence of severe infections was higher with BsAb (40%) than CAR-T (26%) or ADC (8%), including grade

Background: Novel therapeutic targets are urgently needed for treating drug-resistant non-small cell lung cancer Regulator of G protein signaling 20 (RGS20) is identified as an upregulated factor in many cancers, yet Methods: Immunohistochemistry and lung cancer tissue microarray were used to verify the expression of role of RGS20 as a promising novel molecular marker and a target for future targeted therapies in lung cancer

Jacob Lee and Jin Choe met in ninth grade in English class and have been friends since.

December 8, 2023 Abstract " Background: Acute respiratory distress syndrome (ARDS) is a disease with high Compared with the control group, we found higher mortality, more pronounced body weight changes, more serious