Notably, we also confirmed these phenotypes of RGS16 in organoids originated from resected primary human

muscle actin (αSMA), the profibrotic factor transforming growth factor β1 (TGFβ1), and collagen in a human

Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell

be the Principal Investigator of the Receptor Biology Section at the Medical Research Council (MRC) -Human

be the Principal Investigator of the Receptor Biology Section at the Medical Research Council (MRC) -Human

Sabrina Simoncelli , Peter J McCormick , Richard Philip Grose Tags cancer biology , cell biology , human

"Establishing a nonproductive, quiescent infection within monocytes is essential for the spread of human

Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb

Materials and methods: The viability and apoptosis of human DPSCs (hDPSCs) were determined using Cell

In this study, we found that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer

Somatostatin receptor 2 (SSTR2) is a G-protein-coupled receptor (GPCR) with diverse biological functions in humans

., certain asbestos) fibers in humans and experimental animals are thought to involve modes of action

genetic risk factors implicated in schizophrenia by large whole-genome association studies (GWAS) in humans

G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated

Previously, we reported that the G-protein-coupled human muscarinic receptor could bypass tyrosine kinases

Methods: We studied human and mouse PMN signaling elicited by mtDAMPs (GPCR surface expression; protein

His research interest lies in understanding the molecular basis for human tumor development and how to Stehlik et al. have reported that ADGRG6 expressed in lipopolysaccharide stimulated human umbilical vein

SIGNIFICANCE STATEMENT: Human genetic variant/mutation information has expanded rapidly in recent years

Results: We observed that CXCR4 forms heteromers with LPA1 in recombinant HEK293A cells and the human

GPR110 is highly expressed in mouse and human NPCs and neurons, while its expression was absent in astrocytes

During my Ph.D. at the International Max Planck Research School “The Leipzig School of Human Origins”

immune cell function Claudia Stäubert September 15, 2021 at 7:00:00 PM Learn More >> Engineering a human

We carefully screen anyone signing up to the Ecosystem to ensure they are real humans working on GPCRs

of GPCR biology, acquired critical expertise, and rigorous approaches to examine PAR1 function using human

As part of Farooqi's team, he characterized a series of novel human genetic variants identified in several

Ana Lilia Moreno Salinas Read More 12:00 PM Session IV AGPCRs signaling in the nervous system Joseph Duman Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript Variants in Mouse Kidney Joseph Duman Mechanism of Adhesion GPCRs Stephanie Häfner The NTF Release Sensor Approach for Drug Discovery for Human

We de-termined the crystal structure of the human ADGRB2/BAI2 hormone receptor (HormR) and GAIN domains

Daniel Kahne and Suzanne Walker studying the structure and function of the essential human enzyme, O-GlcNAc