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a two-step model, where first the C-terminal region of the peptide interacts with the extracellular domain of the receptor and, subsequently, the N-terminus interacts with the seven transmembrane domain of the

of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN) domain

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This gap is due to their unique autoproteolytic cleavage in the GAIN domain, creating a heterodimer of Affiliations "Ana Lilia Moreno Salinas (2), Arturo Mancini (1), Raida Jallouli (2), Richard Leduc (2) (1)Domain Laurent Sabbagh on the web Domain Therapeutics Characterizing hADGRE5/CD97 Activation and Signaling: Domain Therapeutics North America Inc., Montreal, Quebec, Canada 3.

TA-independent Mechanism of aGPCR Activation: Direct Communication of Extracellular Region with Transmembrane Domain TA-independent Mechanism of aGPCR Activation: Direct Communication of Extracellular Region with Transmembrane Domain of aGPCR activation, the ECR acts as a protective cap for the TA peptide to hide it within the GAIN domain It has been suggested that the TA can regulate receptor signaling without coming out of the GAIN domain biological forces are smaller than 200 pN, the force that is needed to separate the TA from the GAIN domain

I then started my career at Evotec before moving to Domain Therapeutics (called Faust pharmaceutical

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MIT and Harvard Med School in the lab of Hidde Ploegh , where he developed new applications of single-domain

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Our recent study revealed that a protein complex consisting of copper metabolism MURR1 domain-containing

Furthermore, we elucidate the binding site engaging a sizable extracellular domain on GPRC5D for scFv

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While the location of the mutations across the protein domains did not differ significantly in the two

Complex 1 (Ferritin-HrpE/YscL family type III secretion apparatus protein), Complex 2 (Protein kinase domain-containing

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Here we analyze the RGS domains of 15 RGS protein family members using a novel bioinformatic tool that

During that time, I investigated the effect of lung cancer-related mutations in the GAIN domain of the

restriction is prohibited by applicable law), and you agree not to register or attempt to register any domain For example, you may not use our marks: - in domain names - as app icons or featured in an app - as the

We showed that oligomeric Aβ binds to ADGRC3 on the same domain required for the interaction with Frizzled3

Demet's research on the gain domain of adhesion GPCRs started during his postdoctoral studies and continued

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