Somatostatin receptor 2 (SSTR2) is a G-protein-coupled receptor (GPCR) with diverse biological functions The expression of SSTR2 and EGFR was evaluated by immunohistochemistry (IHC) in 491 cases of NPC and The study found that patients receiving chemoradiotherapy (CR) with high expression of SSTR2, high expression Interestingly, NPC patients with high expression of SSTR2, high expression of EGFR, high coexpression Weiyuan Wang , Songqing Fan Tags biomarkers , tumor , head and neck neoplasms , immunohistochemistry , proteins

G protein-coupled receptors (GPCRs) are involved in endocrine and metabolic processes as well as many GPR50 (G protein-coupled receptor 50) is an orphan GPCR that shares the highest sequence homology with GPR50 expression was observed to be significantly increased in the adipose tissue of obese T2DM mice, Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Furthermore, the effects are mediated through the regulation of the IRS1/AKT signaling pathway and PPAR-γ expression

Published date March 1, 2024 Abstract "Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2) is a G protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling molecules , such as protein kinase A (PKA), phosphatidylinositol 3-kinase (PI3K), and phospholipase C. In MCF-7 cells stably-expressing VIPR2, KS-133 decreased PI3K activity and cAMP levels.

Neuropeptide Y (NPY) is an abundant neurohormone in human breast carcinomas that acts on a class of G-protein coupled receptors, of which NPY1R and NPY5R are the most highly expressed. In human breast tumor tissue, we show via immunofluorescence that NPY5R protein levels and colocalization with hypoxia correlate with advanced cancer, and NPY1R protein correlates with adverse outcomes.

Mediated in part by highly druggable extracellular proteins, this axis plays essential roles in fibrosis as the purinergic gene with the strongest association with hypoxia, the highest cancer cell-specific expression pharmacological strategies we demonstrate mechanistically that this ATP-driven invasion requires direct protein-protein

by G protein-coupled receptors (GPCRs). The structure was first snapshot of the agonist- and G protein-bound GPCR, providing valuable models for agonist-mediated activation of G proteins. We continue to utilize these data to better understand the basis for receptor-G protein specificity and changes in G protein structure.

Targeted Therapy Published date October 4, 2024 Abstract "Olfactory receptors (ORs) are a class of G protein-coupled Increasing evidence reveals the heightened expression of olfactory receptors in tumorous tissues and Authors Yi Tang, Ye Tian, Chun-Xia Zhang, Guo-Tai Wang Tags G Protein-coupled receptors , Olfactory receptors

We used The Cancer Genome Atlas (TCGA) GBM genomic dataset to identify differentially expressed genes We investigated the prognostic values of the guanine nucleotide-binding protein G(i) alpha subunit (GNAI Within this dataset, we observed the association in the tumor microenvironment between the gene expression MetaCore and gene ontology (GO) analyses were conducted to explore the role of GNAI3 in co-expressed A single-cell analysis was used to assess GNAI3 expression in GBM.

Session II AGPCR signaling pathways and trafficking Localization of putative ligands for adhesion G protein-coupled Processing, Trafficking And Signalling Pal Kasturi Localization of putative ligands for adhesion G protein-coupled inhibitors of the hypoxia-inducible factor pathway and the epigenetic reader MBD2 (methyl CpG binding protein signaling by binding to extracellular matrix proteins and mechanotransduction. Stehlik et al. have reported that ADGRG6 expressed in lipopolysaccharide stimulated human umbilical vein

Preliminary findings indicate that the simultaneous loss of Bai3 and Tp53 expression in our mouse model We detected and aligned three Adgrf5 exons that undergo differential expression in the kidney: exons Moreover, the complete repertoire of aGPCRs expressed in the kidney is undefined. These results reveal the complete set of aGPCRs expressed in the murine kidney. KCC-07 is an inhibitor that prevents MBD2 from binding to DNA, allowing re-expression of BAI1.

axis in signal transduction Published date September 1, 2023 Abstract "CCN1 and CCN2 are matricellular proteins CCN proteins act to facilitate signaling events involving extracellular matrix proteins. Lysophosphatidic acid (LPA) is a lipid that activates G protein-coupled receptors (GPCRs), enhancing Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell There are multiple examples of the induction of CCN proteins by LPA, and by the related lipid mediator

and ADGRC3, are localized in the developing and adult synapses and interact with synaptic scaffold proteins Several adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles via effects on GBM stem cell self-renewal and metabolism, but also has a therapeutically favorable expression pattern: it is highly expressed in all GBM specimens, but is absent from healthy brain tissue. To exploit this expression profile, we have developed antibody-drug conjugates (ADCs) targeting CD97,

hepatocellular carcinoma via GPCR-related genes analysis Published date May 15, 2024 Abstract " Background: G protein-coupled shrinkage and selection operator (LASSO) were performed with the aim of identifying differentially expressed Differential expression and functional enrichment analyses were performed; protein-protein interaction

Drosophila Beatriz Blanco Redondo Abstract "The Drosophila genome contains five loci encoding adhesion G-protein In vivo expression profiling has shown Remo expression in the central (CNS) and peripheral nervous systems In L3 PNS specimen Remo is expressed in a subset of neurons expressing the DEG/ENaC channel pickpocket Remo homolog ADGRA2/Gpr124 cooperates with other GPCRs of the Frizzled family, and the transmembrane proteins Collectively these proteins form a cell surface complex that acts as a recognition platform for Wnt ligands

Canada where she obtained her Ph.D. at the University of Western Ontario, working on the regulation of G proteins signaling by accessory proteins, such as RGS proteins and GPSM proteins.

For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Tall moved upstairs to conduct his postdoctoral work on heterotrimeric G proteins and the novel interactor The current goals of the Tall lab are to understand the basic mechanism by which Ric-8 proteins fold all heterotrimeric G protein alpha subunits, to exploit a Ric-8-based technology to purify recombinant G proteins and to use the G proteins in assays to explore the mechanisms of action of the 33-member Mechanical dissociation of the two fragments aided by protein binding ligands and cell movement serves

as a potential drug target due to its high expression in triple negative breast cancer. Mike expressed his initial reluctance due to a lack of confidence and fear of not being ready. The conversation ended with Yamina expressing interest in learning more about Mike's two main research They also discussed the challenges they face in studying GPCRs due to their low expression levels and Mike expressed a need for better tools to study GPCR localization in tissues.

In her postdoctoral period, she has participated in the identification and characterization of proteins that act at the level of G proteins and which are part of a multimolecular signaling complex (AGS, de “Activators of G-protein signaling). Ribas' group has described a new interaction region in a cellular protein that has turned out to be very Ribas has also described a new protective role of G protein-coupled receptor kinase 2 (GRK2), a known

My project is investigating a new protein ligand for a GPCR and its potential role in obesity. During his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors GPCR Title: Synapse-Associated Protein 102 and Post-Synaptic Density 95 Differentially Shape Dopamine About Bassam Albraidy "My thesis focus on studying the interaction of dopamine D1 receptors scaffolding proteins synapse-associated protein 102 and post-synaptic density 95, and the impact of these complexes in D1R-mediated

CXCL12-induced signaling and cell migration Published date September 25, 2023 Abstract "Background: G protein-coupled functional implications of the CXCR4-LPA1 heteromer, we performed various assays, including cAMP, BRET for G protein Coexpression of LPA1 with CXCR4 reduced CXCL12-mediated cAMP inhibition, ERK activation, Gαi/o activation LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express , Dong-Seung Seen , Jae-Yeon Jeong , Won-Ki Huh Tags Cancer , Chemokine receptor 4 , Chemotaxis , G protein-coupled

Over the course of my graduate work, I gained experience with structural mass spectrometry and protein crystallography, which shaped my interest in understanding how protein dynamics are linked to function John expressed his comfort in sharing his stories and agreed to follow Yamina's guidelines. machines and decided to work on memory proteins. The conversation concluded with both John and Yamina expressing a desire to support the academic community

Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of GPCRs and a small family of accessory proteins called RAMPs. Ilana’s research is multi-disciplinary and involves a close collaboration with proteomics experts at

< GPCR News < GPCRs in Oncology and Immunology High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro Published date June 26, 2023 Abstract "G protein-coupled Previous studies have indicated that GPR50 could protect against breast cancer development and decrease To detect the role and the regulation mechanism of GPR50 in HCC, GPR50 expression was analyzed in HCC patients (gene expression omnibus database (GEO) (GSE45436)) and detected in HCC cell line CBRH-7919

GPCR Title: Balancing G Protein Selectivity and Efficacy in the Adenosine A2A Receptor About Louis-Philippe receptors (GPCRs) and G protein activation. GPCR Title: Development of a Transgenic Mouse Platform for the Detection of Endogenous G protein Activity Mikel Garcia-Marcos which investigates GPCR and G protein signaling" Remi Janicot on the web Boston University She then joined Andrew Kruse’s lab for her postdoc in 2018 where she has employed protein engineering