Search Results
98 items found for "survival analysis"
- Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway for Cell Migration
immobilized titanium (IV) ion affinity chromatography (Ti4+-IMAC) for label-free quantification (LFQ) analysis Data analysis revealed that 27 phosphopeptides corresponding to six proteins were involved in the Hippo
- Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell therapy
Secondary analysis evaluated risk factors for late respiratory infections using univariate and multivariable On multivariable analysis, hypogammaglobulinemia (hazard ratio [HR], 6.06; P = .044) and diagnosis of
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
Statistical analysis using GEO datasets was conducted. showed weak antagonistic activity on M3, which was confirmed to be a disease target by statistical analysis
- Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
After 2-24 h, brains were collected for the analysis of gene expression by RT-PCR or protein expression with LPS (100 ng/ml) followed by 10 nM synaptamide for 2 h for gene expression and 12 h for protein analysis
- Ep 151 with Dr GPCR Board
Steering Committee of the San Diego Supercomputer Center, and provided consultation for genetic sequence analysis Bioinformatics Core Facility Manager, where they managed a technical support team providing scientific data analysis and database development services, contributed analytic support resulting in authorship of numerous point of contact for customers assessing features of software products for drug discovery and genomic analysis
- Ep 136 with Murat Tunaboylu & Ben Holland
engineering and has been working in machine learning for nearly 10 years, applying it to antibody generation, analysis
- Noval insights and therapeutic strategies for tumor-induced kidney pathologies
findings by emphasizing the structural and evolutionary significance of TACR3 and provided an in-depth analysis
- Ep 33 with Dr. David E. Gloriam
GPCRdb database where ~4,000 researchers each month retrieve reference data and access online tools for analysis
- The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer
Our structural analysis reveals that the GPRC5D presents a close resemblance to the typical Class C GPCRs
- Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus
Tags double mutant cycle analysis , protein expression , protein-protein interaction , receptor binding
- Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells
CRISPR/Cas9 targeting of PAR1 and PAR2 combined with microarray analysis revealed genes that are regulated
- High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
To detect the role and the regulation mechanism of GPR50 in HCC, GPR50 expression was analyzed in HCC mechanism of GPR50 in HCC was detected by isobaric tags for relative and absolute quantification (iTRAQ) analysis
- GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis
Our multi-omics analysis of NKTCL revealed that EBV gene pattern correlated with immune-related oncogenic
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
mutations in UM must co-occur with other mutations to activate FAK/YAP/TAZ signaling, and our bioinformatic analysis
- Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation
Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration
- Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis
Subsequent signaling analysis reveals a strict requirement of phospholipase C β3 (PLCβ3) and its downstream
- Identification of Small-Molecule Antagonists Targeting the Growth Hormone Releasing Hormone Receptor (GHRHR)
Preliminary analysis of the specificity/selectivity of one of the most effective hit compounds indicated
- GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
In gene expression analysis of mouse lungs with induced fibrosis, eight GPCRs were identified, showing
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium
The expression of GPR15 and c10orf99/gpr15l mRNA was analyzed by RT-qPCR. Samples of synovial fluid and peripheral blood were analyzed for CD45+CD3+CD4+GPR15+ and CD45+CD3+CD8 Statistical analysis included Kruskal-Wallis test, T-test, or Mann-Whitney U test, according to data
- G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions
To this end, we focused on analysis of bacterial metabolites that are currently recognized to bind to
- Clinical, pathophysiologic, genetic and therapeutic progress in Primary Bilateral Macronodular Adrenal Hyperplasia
Genetic analysis is now available for early detection of family members of index cases with PBMAH carrying
- Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways
this synergistic pharmacodynamic interaction, liquid chromatography-mass spectrometry-based proteomic analysis
- Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus
The docked scores of Complex 1, Complex 2, and Complex 3 were validated using MD simulation analysis,
- Classified News | Dr. GPCR Ecosystem
receptor identifies small molecules that inhibit midgut contractions Read More October 8, 2024 Global analysis
- Comparison of infectious complications with BCMA-directed therapies in multiple myeloma
In this retrospective, single-center analysis we evaluated infectious complications after BCMA-targeted
- Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer
Speculatively, previous studies on gene expression analysis of RHBDF2 showed heterogenous behaviour during
- Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
expressed genes (DEGs) in an acute lung injury (ALI) model were identified, and functional enrichment analysis
- Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
Ceddia 1, *, Zack Zurawski 2,3,*, Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer This is one of the top Pharmacology departments in the country, judged by reputation, citation analysis