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173 items found for "A3 adenosine receptor"
- Ep 51 with Dr. Mark Connor
Ph.D. from Department of Pharmacology, University of Washington (1992, mentor Charley Chavkin , sigma receptors Focus on study of drugs and toxins on GPCR (opioid, cannabinoid receptor) and ion channel (K, Ca, TRP
- The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy
GPCRs in personalized cancer therapy Published date September 12, 2024 Abstract "G protein-coupled receptors (GPCRs) are vital cell surface receptors that govern a myriad of physiological functions.
- Ep 59 with Dr. Nicola J. Smith
developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed from other receptors this expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors
- AGPCR 24 Student Flash Presentations
Flash Presentations Health and Disease, Metabolism, Nervous System, Proteomics and Transcriptomics, Receptor Adhesion GPCR Signaling In Vivo Lara-Sophie Brodmerkel Novel isoforms of adhesion G protein coupled receptor Recent studies implicate the dysregulation of adhesion G-Protein coupled receptors (GPCRs) in GBM development However, the physiological relevance of flap flexibility on receptor activation and signaling remains The cleaved BAI1 isoform has a 19 amino acid extracellular stalk that can serve as a receptor agonist
- Structure-based discovery of functionally selective 5-HT1A receptor agonists
GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective 5-HT1A receptor
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
GPCR News < GPCRs in Oncology and Immunology [Inhibitory effect of downregulating G protein-coupled receptor date March 27, 2024 Abstract "Objective: To clarify the effect and the mechanism of G protein-coupled receptor gingival fibroblasts (GFs), thus to provide a foundation for delving into the role of G protein coupled receptor
- Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant
Chemokine-mediated neutrophil recruitment is determined by Cxcr2 receptor signaling, Cxcr2 endocytosis These data collectively indicate that optimal glycosaminoglycan interactions and dampened receptor activity
- Ep 18 with Dr. Yamina Berchiche
G protein-coupled receptors (GPCRs) mediate a vast variety of critical biological processes and provide for quantitative, and multi‐scale integration of these amounts of data to gain novel insights into receptor
- Explore / Individuals | Dr. GPCR Ecosystem
Find out about your favorite receptor or company today! Job listings Are you looking to hire?
- Ep 104 with Dr. Raul Gainetdinov
Since 2013, he has been elected Chair of the subcommittee for the Dopamine receptors of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification
- Ep 103 with Dr Kathleen Caron
With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular
- Adhesion GPCR Workshop 2024 Full Agenda
Flash Presentations Health and Disease, Metabolism, Nervous System, Proteomics and Transcriptomics, Receptor Plenary Lecture Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Jinpeng Sun Read More 2:00 PM Lunch Read More 3:00 PM Session I Tethered Monserrat Avila Zozaya Read More 4:30 PM Board meeting/General assembly Read More 5:30 PM Leave for dinner reception Read More 6:00 PM Reception dinner Read More Oct 25 - 9:00 AM Session VI AGPCRs shaping the nervous
- Ep 50 with Dr. Thomas P. Sakmar
also went on to discover a “counterion switch” in visual pigments and to develop strategies to assay receptor-G-protein from this work, such as the concept of “functional micro-domains” and the “helix movement model of receptor , the parallel development of bioorthogonal labeling strategies to couple fluorophores to expressed receptors
- Biochemical Mechanisms Underlying Location Bias in GPCR Signaling
approaches to quantify ligand bias and the identification of ACKR3 as an endogenously beta-arrestin-biased receptor His group and others have shown that many of these ligands act as biased agonists for the same receptor
- Ep 53 with Dr. Timo De Groof
within the research group and used this platform to develop nanobodies targeting viral G protein-coupled receptors with a special focus on the human cytomegalovirus-encoded chemokine receptor US28.
- Ep 144 with Dr Aurélien Rizk
Aurelien Rizk shared that he had always focused on GPCRs but had also worked on other types of receptors Yamina Berchiche had a detailed conversation about the intricacies of cell signaling and chemokine receptors They validated their technology and made collaborations for expertise on chemokine receptors. Therapeutic Effect and Receptor Interactions Aurelien Rizk and Yamina had a detailed discussion about They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor
- Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
< GPCR News < GPCRs in Oncology and Immunology Increased protease-activated receptor 1 autoantibodies
- Biased agonism at the GLP-1 receptor: from structure to animal models of disease
Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Biased agonism at the GLP-1 receptor
- GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
mesenchymal transition of glioblastoma Published date November 19, 2023 Abstract "G protein-coupled receptor The map incorporates more than 100 molecular entities including kinases, receptors, ion channels, and
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular
- Ep 54 with Dr. JoAnn Trejo
thorough and mechanistic understanding of processes that control cell signaling by protease-activated receptors Her laboratory is the recognized expert on protease-activated receptors, particularly PAR1, and over
- Ep 151 with Dr GPCR Board
GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the thorough and mechanistic understanding of processes that control cell signaling by protease-activated receptors Her laboratory is the recognized expert on protease-activated receptors, particularly PAR1, and over
- Classified News | Dr. GPCR Ecosystem
Contributors Read more articles from our Contributors Call for GPCR papers GPCR Binders, Drugs, and More Receptor
- Ep 08 with Dr. Graciela Pineyro
She has done extensive work on the molecular pharmacology of opioid receptors and is currently focusing
- Ep 97 with Robert Laprairie
The focus of his research is the molecular pharmacology of cannabinoids and cannabinoid receptors.
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
cytoskeleton organization by the kinase effectors of Rho GTPases" and "Immune response B cell antigen receptor Kumar , Adrian Wangsawijaya Santoso , Bianca Tobias William , Chih-Yang Wang Tags G-protein-coupled receptor
- GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway
This autoimmune loop in psoriasis pathogenesis is influenced by G protein-coupled receptor (GPCR) signalling Role of GPR97 is indispensable and this adhesion receptor may affect immune cell enrichment and function
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium
GPR15 is a G protein-coupled receptor (GPCR) located on chromosome 3 and has similarity in its sequence with chemokine receptors.