The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege

, in the case of promiscuous receptors they found that these receptors shared conserved residues of both G protein families, suggesting that receptors that activate both Gs and Gi/o do so by combining the

Both groups of metabolites suppress anti-inflammatory interleukin-10 signaling in human macrophage cell

Def and Mrgpra2 mutant animals both exhibited skin dysbiosis, with reduced microbial diversity and expansion

In contrast to A2AAR agonists, which simultaneously interact with both Ser2777.42 and His2787.43, 2 only

Recently, X-ray structures of both AngII receptors (AT1 and AT2 receptors) bound to peptide and non-peptide

Additionally, RAMP2 increases both PTH- and PTHrP-triggered β-arrestin2 recruitment to PTH1R.

use of various drugs including orthosteric and allosteric ligands acting on either mGluR2, mGluR3 or both

She will maintain both of these roles, in addition to her role at Exscientia .

In this review, we discuss both the ‘friend’ and ‘foe’ features of TGR5 by summarizing its tumor-suppressing

a NanoBRET-based conformational histamine H3 receptor (H3R) biosensor that allowed the detection of both

We have explored hydrophobic groups of different sizes on both sides of the five-membered ring scaffold

Infiltrating GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients

Although the high-resolution crystal structures of the DOR with both agonist and antagonist have recently

Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in

Since we cover both the theoretical as well as practical aspect of these topics, the platform addresses

In the experiment, similar sets of residues were found to be in significant contact with both ligands

This is also where Gq/Gs bind the receptor through both hydrophobic and polar interaction, while Gi/G12

domain 1 (FnIII.1) suggest the cysteine-rich (CR) and the FnIII.1 domains could assist the WAP domain both

discussed that one should consider when attempting to compare functional outcomes from different studies, both

Both PAR4 and PAR2 are able to drive the association of methyltransferase EZH2 with β-catenin, culminating

Meanwhile, the antagonist ligands made interactions with W2866.48×48 and Y3167.43×42, both residues considered

sites of N-acetyl galactosamine (GalNAc)-type O-glycosylation in their N-termini as well as sulfation, both Both PTMs were shown to contribute to the binding of CCL5 and CCL8 and to a minor extend CCL3. The combined effects of both PTMs as well as the relevance of specific acceptor sites and glycan composition

Pharmacological targeting of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717,

Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both

In vivo, suppression of postsynaptic cAMP signaling in CA1 neurons prevented formation of both Schaffer-collateral

interactome includes numerous proteins which interact with differential domains of GRK2 to modulate both

evident increase in SRE-luc activity was noticed when COS-7 cells expressing GnIHR were challenged with both