cancer therapy Published date September 12, 2024 Abstract "G protein-coupled receptors (GPCRs) are vital cell highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity, cancer cell Treatment Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the She is also very active within the pharmacology community and currently serves on the editorial board Given her expertise in GPCR pharmacology and scientific communication, she is poised to make valuable Monserrat Avila Zozaya I did a PhD in cell biology at CINVESTAV, Mexico. My long-term interest is focused on understanding the mechanisms mediated by GPCRs at the cellular communication

ovarian cancer prognosis Published date June 18, 2024 Abstract " Background: Ovarian cancer (OV) is a common G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated The levels of GPCRRGs were examined in normal and OV cell lines using quantitative reverse-Etranscription epithelial Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

, 2023 Abstract "Macrophages release soluble mediators following efferocytic clearance of apoptotic cells to facilitate intercellular communication and promote the resolution of inflammation. macrophage Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Immunology Itaconate in host inflammation and defense Published date March 5, 2024 Abstract "Immune cells Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory itaconate Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune cell Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

co-founder of InterAx Biotech, where he specializes in the development of a technology platform deciphering cell about the intricacies of cell signaling and chemokine receptors. Yamina shared her research experience, emphasizing the fascination of understanding how cells respond significance of interdisciplinary teamwork in drug and technology development, noting the challenges of communication job opportunities at Interax Biotech, with Aurelien Rizk and Yamina clarifying that job openings are communicated

Replication by Regulating Ca2+ Flux Published date May 29, 2023 Abstract "Chemokine production by epithelial cells coronavirus porcine epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Laboratories cell-porcine kidney 1 epithelial cells (LLC-PK1). Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

where he was exposed for the first time to the nascent field of membrane biophysics and intercellular communication learned gene synthesis, cDNA cloning, site-directed mutagenesis, and heterologous expression in mammalian cells suppression method to genetically encode unnatural amino acids into membrane proteins expressed in mammalian cell with Yu Chen and Ping Chi , that a mutant of CYSLTR2 is a driver oncogene in uveal melanoma, the most common

Promotes Osteogenic Differentiation Published date May 30, 2023 Abstract "Objectives: Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cell possessing self-renewal and multilineage differentiation Materials and methods: The viability and apoptosis of human DPSCs (hDPSCs) were determined using Cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling pathways in immune cells His laboratory uses knock-out and transgenic mouse models, along with different cell culture systems, to understand the role of immune cell GPCRs and their cross-talk with other insulin-sensitive tissues Sai Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research

Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis and PKC via the signaling pathway of miR-19a/GRK6/GPR39/PKC, which accordingly resulted in suppressed cell apoptosis and promoted cell migration and invasion. scRNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

complications with BCMA-directed therapies in multiple myeloma Published date May 31, 2024 Abstract "B-cell-maturation-antigen single-center analysis we evaluated infectious complications after BCMA-targeted chimeric-antigen-receptor T-cell Comparing T-cell redirecting therapies, the incidence rate of severe infections was significantly lower M Lesokhin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Simone Prömel Simone Prömel is currently a professor of cell biology at the Heinrich Heine University of action of Adhesion GPCRs and found that they do not only mediate classical G protein signals into cells but can also communicate solely via their N termini.

In response to a chemoattractant stimulation, cells lacking PLCγ2 (plcg2kd) displayed altered dynamics phosphorylation and cofilin activation; impaired dynamics of actin polymerization; and consequently, defects in cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

G protein-coupled receptors (GPCRs) are involved in endocrine and metabolic processes as well as many increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation in 3T3-L1 cells Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

This activation promotes neurogenic differentiation of neural stem cells, neurite growth, and synaptogenesis Under nutrient depletion, the model choanoflagellate Salpingoeca rosetta forms distinct cell types that We found that the knock-out of cupidon induces a gain in cell adhesion and cell fusion, resembling the mating behavior of wild-type cells under nutrient depletion. Cupidon mutants, similar to starved wild-type cells, upregulate various extracellular matrix-related

Beatriz Blanco Redondo The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Collectively these proteins form a cell surface complex that acts as a recognition platform for Wnt ligands Scholar X (Twitter) The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Anette 4, Ließmann Fabian 5, Meiler Jens 5, Schöneberg Torsten 2,6, Prömel Simone 1 1 Institute of Cell Willem Berend Post on the web Cell Biology LinkedIn < Previous Session Next Session >

roles of AGPCRs in the periphery ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells health and disease Douglas Tilley ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells Centre for Experimental Medicine, Institute for Biocehmistry and Molecular Cell Biology, University Medical Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2012 - 2015 Postdoctoral fellow, Department of Cell impact cardiac structure and function, and has evolved to encompass their roles in regulating immune cell

To Their Niche And Leads To Myeloid Skewing Emmanouil Kyrloglou A single cell GPCR map of thermogenic G-protein-coupled receptors, which exhibit large multi-domain extracellular N-termini that mediate cell-cell and cell-matrix interactions. Renal Adgrf5 is restricted to two distinct populations of cells: AICs and endothelial cells (ECs). These data demonstrate that Adgrf5 transcript variants are cell-specific in the kidney.

research interests lies in the elucidation of signal transduction pathways in cancer, immune and bone cells area of interest has been the elucidation of the molecular basis for a rare autosomal human disease called The Rottapel lab has shown that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell

Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used , RNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

controlling their steady state trafficking and sometimes their agonist-induced internalisation, as well Norbin in the trafficking of endogenous C5aR1 and CXCR4 in primary neutrophils by flow cytometry and cell β-arrestin-dependent mechanism and limits the recycling of internalised C5aR1 and CXCR4 back to the cell C5a-stimulated membrane translocation of Tiam1, Vav, and PKCδ, and activation of Erk and p38 Mapk pathways, as well β-arrestin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

of Technology in Genova, Italy (2008-2016) and an Associate Research Professor in the Department of Cell Before joining the Department of Cell Biology in 1996 as a postdoc and becoming faculty at Duke in 2000 As of August 2022, he has over 270 publications in scientific journals (including Science, Nature, Cell

GPCR Ecosystem About Monserrat Avila Zozaya I am a cell biologist interested in studying GPCRs, especially developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

GPCR Community Presentation Monserrat Avila Zozaya Read More 11:30 AM Session VIII Physiological and compact multidomain module of fourteen domains which regulates signaling Vasiliki Karagiannakou A single cell Latrophilin/Cirl Demet Araç An ECR-Mediated and TA-independent Mechanism of aGPCR Activation: Direct Communication Axons Monserrat Avila Zozaya The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell Role Of CELSR1 (ADGRC1) In Breast Cancer Emmanouil Kyrloglou GPR124 Mediates Adhesion Of Leukemic Stem Cells

Yuling Feng The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell Stephen, Caron Kathleen M Department of Cell Biology and Physiology at UNC Chapel Hill 111 Mason Farm Van Meir’s research examines how genetic alterations and hypoxia induce changes in cell biology that To address these gaps in knowledge, we used biochemical and cell-biological approaches using cell-lines

and “poly proline region docking theory” etc. to explain the arrestin mediated GPCR functions (Nature communications TRPC3 coupling by forming a complex of AT1R/β-arrestin-1/PLCγ/TRPC3 or M3R//β-arrestin-1/TRPC3 (Nature communications , 2017, Nature communications, 2018). Advance 2021, PNAS 2023, Nature Metabolism 2023), recognition of amine containing hormones by GPCRs (Cell