During my Ph.D. at the International Max Planck Research School “The Leipzig School of Human Origins” Claudia discussed developing an ecosystem for the GPCR University, with the goal of providing a central hub

GPCRs regulate many functions in the human body and have earned the title of "most targeted receptors

His research team has pioneered the study of G proteins and G protein coupled receptors (GPCRs) in human

functional enrichment analyses were performed; protein-protein interaction (PPI) mechanisms were explored; hub

Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers of hundreds

Previously, we reported that the G-protein-coupled human muscarinic receptor could bypass tyrosine kinases Authors Trang T T Nguyen , Wen Lu , Wandi S Zhu , K Mark Ansel , Hong-Erh Liang , Arthur Weiss .

Noor A Lokman, Carmela Ricciardelli, Martin K Oehler, Anton Blencowe, Sanjay Garg, Katherine Pillman, Hugo

Notably, we also confirmed these phenotypes of RGS16 in organoids originated from resected primary human Authors Hao Shen, Jie Yuan, Dafeng Tong, Bingchen Chen, Enda Yu, Guanglei Chen, Cheng Peng, Wenjun Chang

However, a new study suggests that long-term use of P2Y12R inhibitors may increase the risk of cancer Authors Yanni Xi, Zhenya Min, Mianxue Liu, Xueqin Li, Zhao-Hua Yuan Tags P2Y12R , P2Y12R inhibitors ,

genetic risk factors implicated in schizophrenia by large whole-genome association studies (GWAS) in humans

Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell

SIGNIFICANCE STATEMENT: Human genetic variant/mutation information has expanded rapidly in recent years

muscle actin (αSMA), the profibrotic factor transforming growth factor β1 (TGFβ1), and collagen in a human

Scordo, Gunjan L Shah, Hani Hassoun, Kylee Maclachlan, Neha Korde, Urvi A Shah, Carlyn Rose Tan, Malin Hultcrantz

Authors Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication

Methods: We studied human and mouse PMN signaling elicited by mtDAMPs (GPCR surface expression; protein

He began his career in the late 1960s and has been an Investigator of the Howard Hughes Medical Institute

Miller 1, Shijiao Huang 1, Elizabeth S. Dean 1, and Scott F. Leiser 1 1.

Department of Drug Design and Pharmacology in Copenhagen, he worked on novel analytical methods to identify human

to find, create and optimize Frizzled-targeting small molecule drugs to improve future therapies of human

Maudsley was awarded a Howard Hughes Medical Institute Fellowship to train with Professor Robert Lefkowitz be the Principal Investigator of the Receptor Biology Section at the Medical Research Council (MRC) -Human

She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced at the MRC Human Reproductive Sciences Centre, Edinburgh, a move to Perth, Australia resulted in her

Notably, GPR132 activation by 8GL promoted differentiation and reduced colony formation in human AML Notably, genetic or pharmacological activation of GPR132 triggered the differentiation of human primary Authors Chunyang Yi, Jiacheng He, Dan Huang, Yumiao Zhao, Chan Zhang, Xiyun Ye, Ying Huang, Ruth Nussinov

infiltration and predicts poor prognosis in ovarian cancer Published date August 15, 2023 Abstract "The long Authors Buze Chen , Xiaoyuan Lu , Qingmei Zhou , Qing Chen , Siyan Zhu , Guilin Li , Hui Liu Source Contribute

Maudsley was awarded a Howard Hughes Medical Institute Fellowship to train with Professor Robert Lefkowitz be the Principal Investigator of the Receptor Biology Section at the Medical Research Council (MRC) -Human

"Establishing a nonproductive, quiescent infection within monocytes is essential for the spread of human

G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated

orthosteric and allosteric interactions, and still looking for some bias ... anywhere ... these days human