arrestin signaling Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer perspectives of CXCR4 antagonists for disease therapy GPCRs in Cardiology, Endocrinology, and Taste Transcriptomic stress mechanotransduction at endothelial junctions GPCRs in Neuroscience Male-specific behavioral and transcriptomic bioinformatics analysis to construct a risk model for ovarian cancer prognosis GprC of the nematode-trapping Leukemia Methods & Updates in GPCR Research The ufmylation cascade controls COPII recruitment, anterograde transport

Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

intracellular agonist The psychosis risk factor RBM12 encodes a novel repressor of GPCR/cAMP signal transduction inflammation-mutation model Methods & Updates in GPCR Research Current and emerging methods for probing neuropeptide transmission GPCR Events, Meetings, and Webinars ONCORNET2.0 Final Symposium (August 31 - September 1, 2023) 3rd Transatlantic ECI GPCR Symposium (September 7 - 8, 2023) Discovery On Target - DOT (September 25 - 28, 2023) Training Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport

Call for GPCR Papers GPCRs: Signal Transduction. Ends tomorrow - March 31st, 2023. NEW FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

The suppressive rather than activating effects of pGRP were confined to blood flow at a high shear rate Blockage of PTK2 or interference of CIB1 no more than slightly affected thrombus formation at a low shear

GPCRs in Neuroscience GPR160 is not a receptor of anorexigenic cocaine- and amphetamine-regulated transcript Methods & Updates in GPCR Research Activity Map and Transition Pathways of G Protein-Coupled Receptor Transmembrane protein CD69 acts as an S1PR1 agonist. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

featured by the interaction between the N-terminus of the chemokine and the extracellular loops and transmembrane where the negatively charged residues, as a consequence of the negatively charged aminoacids and post-translational GalNAc)-type O-glycosylation in their N-termini as well as sulfation, both PTMs which co-localize in the Trans-Golgi GalNAc-type or mucin-type O-glycosylation is initiated by the transfer of Gal-NAc to a serine or threonine residue by polypeptide GalNAc-transferases (GalNAc-Ts) which is further elongated with the linkage of

Single-cell transcriptome analysis of NEUROG3+ cells during pancreatic endocrine differentiation with Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

Carola Weiss is a Senior Executive with more than 20 years of international experience in the biopharmaceutical

This time with none other than Dr. Bryan Roth There are 10 open tickets available. Get yours now!

chemo-informatics for GPCR drug discovery - Design Pharmaceuticals Call for GPCR Papers GPCRs: Signal Transduction NEW Training School on “Cell-based assays to study Adhesion GPCR function".

Gβγ subunits co-localize with RNA polymerase II and regulate transcription in cardiac fibroblasts. receptors in the molecular pathology and treatment of schizophrenia Call for GPCR Papers GPCRs: Signal Transduction GPCR Events, Meetings, and Webinars 2nd ERNEST Training School. (February 20 - March 3, 2023).

The chemokine system exhibits great versatility, with more than 50 chemokines interacting with over 20 Data Bank (PDB) which reveal common structural features, such as the presence of seven transmembrane CKRs are characterized by a seven transmembrane (7TM) fold structure consisting of three intracellular The arrangement of the seven transmembrane helices creates a ligand-binding cavity on the extracellular This involves an outward swing of the intracellular transmembrane helix 6 (TM6) coupled with an inward

GPCR Podcast, we have none other than Dr. Marta Filizola!

Conformational flexibility of β-arrestins - How these scaffolding proteins guide and transform the functionality The contribution of endocytosis to sensitization of nociceptors and synaptic transmission in nociceptive Transcriptomic analysis of human cytomegalovirus to survey the indirect effects on renal transplant recipients IPI Surfacing (June 15, 2023) GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training

Our guest is none other than Dr. Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.

For my postdoctoral training, I joined one of the labs that participated in Latrophilins’ discovery, Transitioning to study Latrophilins, I decided to test the interaction of neurexins with Latrophilins 38421639 Systematic assessment of the tethered agonist-dependent activities of all 33 aGPCRs in a suite of transcriptional cochlea where it localizes AMPA receptors at the post-synaptic density and plays a crucial role in sound transmission

The move comes less than three weeks after X4 pulled together a $55 million PIPE and amended a loan facility

Neuroscience Spatiotemporal organization of prefrontal norepinephrine influences neuronal activity Transient networks Glycoprotein-glycoprotein receptor binding detection using bioluminescence resonance energy transfer contribute to G protein coupling Reviews, GPCRs, and more Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures Lipid regulation of the Exploring GPCR signaling pathway networks as cancer therapeutic targets Generation of comprehensive GPCR-transducer-deficient

Our first guest speaker is none other than Dr. Ben Myers!

The Ca2+/CaM, Src kinase and/or PI3K-dependent EGFR transactivation via 5-HT2A and 5-HT1B receptor subtypes Emerging approaches for decoding neuropeptide transmission. Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal Stability to GPCR Signal Transduction. Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. 2nd ERNEST Training

Better known as GPCR, the fruitful research space has led to more than 700 approved drugs over previous

GPCR Activation and Signaling Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine Transcriptome profiling of male and female Ascaris lumbricoides reproductive tissues. advanced, recurrent or metastatic solid tumors: the EPRAD study Call for GPCR Papers GPCRs: Signal Transduction Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. 2nd ERNEST Training

Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine Developmental and homeostatic signaling transmitted by the G-protein coupled receptor FPR2. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

Hassard is a commercial leader with more than three decades of experience leading sales and marketing

Reviews, GPCRs, and more Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and the Appointment of Marcella Ruddy, M.D., to the Board of Directors Call for GPCR Papers GPCRs: Signal Transduction SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023). 2nd ERNEST Training School

is quite stable, the number of ORs expressed in different human tissues is highly variable from more than single OR gene however, ectopic ORs expression is unlikely to be modulated by this tight mechanism with transcriptomic

One potential solution is to develop analgesics that act at targets other than opioid receptors.