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Hello Readers👋, We're excited to share our weekly newsletter with you. Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news Bio enter multi-target collaboration to advance development of cachexia therapeutics Sosei Heptares Webinar Deadline February 12, 2023 GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit (June 11 - 16, 2023). 19th World Congress of Basic & Clinical Pharmacology 2023.

Hello Readers👋, We're excited to share our weekly newsletter with you. Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news Update And Financial Guidance Structure Therapeutics Appoints Industry Leaders Eric Dobmeier and Joanne Waldstreicher GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit, (February 21 - 23, 2023) (June 11 - 16, 2023). 19th World Congress of Basic & Clinical Pharmacology 2023.

Hello Readers👋, We're excited to share our weekly newsletter with you. Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. (June 11-16, 2023). 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7).

Hello Readers👋, We're excited to share our weekly newsletter with you. Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. June 11-16, 2023. 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7.

We're excited to be back and share our weekly newsletter! We'll be sending it directly to your inbox every week, so you'll always be the first to know about the Industry News Sosei Heptares and Neurocrine Biosciences won Out-Licensing Deal of the Year from Locust GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. June 11-16, 2023. 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7.

Hello Readers👋, We are working on bringing your the latest GPCR News more frequently directly in your into Phase 2 Clinical Trials for Treating Type 2 Diabetes and Obesity Special report 2022: Meet 20 women GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. June 11-16, 2023. 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7.

GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. June 11-16, 2023. 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7.

Hello Readers👋, We are working on bringing your the latest GPCR News more frequently directly in your Structural and Molecular Insights into GPCR Function Computational investigation of functional water GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. June 11-16, 2023. 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7.

They are G-protein-coupled receptors and bind as ligand retinal, which is bound covalently to a lysine Therefore, we wondered: Do opsins exists that have lost this lysine during evolution? To find such opsins, we built an automatic pipeline for reconstructing a large-scale opsin phylogeny. Thus, we call them gluopsins. However, what their particular function is, remains to be seen."

October 2022 β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling However, whether β-arrestin1 and 2 respond differently for binding to the same GPCR is still unknown. Employing GRK knockout cells and β-arrestins lacking the finger-loop-region, we show that the two isoforms Moreover, we assess β-arrestin conformational changes that are induced specifically by proximal and distal Here, we show differences between conformational changes that are induced by P-R* or R* receptor states

October 2022 Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory liver, white adipose tissue and skeletal muscle. Methods: Using a widely adopted rodent model of 3-day recurrent hypoglycemia, we first checked expression Additionally, we measured circulating FFA and glycerol to check lipolysis.

Here, we introduce azodopa, a novel photoswitchable ligand that enables reversible spatiotemporal control We demonstrate that azodopa activates D1-like receptors in vitro in a light-dependent manner. Azodopa is the first photoswitchable dopamine agonist with demonstrated efficacy in wild-type animals and opens the way to remotely controlling dopaminergic neurotransmission for fundamental and therapeutic

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September 2022 "In the Wnt-β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) Using purified Fzd proteins reconstituted in lipid nanodiscs, we investigated the factors that promote We found that the affinity of Fzd for Dvl was not affected by Wnt ligands, in contrast to other members by Dvl-associated lipid kinases in response to Wnt and which is required for LRP5/6 phosphorylation. Our findings suggest a positive feedback loop in which Wnt-stimulated local PI(4,5)P2 production enhances

February 2022 "Switzerland Today, InterAx Biotech is pleased to announce that Carola Weiss has joined Carola Weiss is a Senior Executive with more than 20 years of international experience in the biopharmaceutical Carola Weiss’ professional career brings deep expertise in business development, marketing & sales, licensing

president of the Royal Society of Chemistry and Founder of (and ongoing consultant to) OMass Therapeutics, which This is a highly prestigious international award – exemplified by the fact that other winners this year

., a clinical-stage global biopharmaceutical company developing novel oral therapeutics to treat a wide range of chronic diseases, today introduced Basecamp Bio, a wholly owned subsidiary dedicated to fueling

Vlaams Instituut Biotechnologie, at the Vrije Universiteit Brusle, Brussels, Belgium, has been named the winner Jan Steyaert will be presented with the Gabbay Award at Brandeis University on October 27 when he will give a public lecture on his work, followed by a ceremony.

August 2022 "We are happy to announce you our 2nd IRN i-GPCRnet meeting that will be held at the University of Wurzburg (Germany) from september 30th to october 1rst."

The Boston biotech revealed Wednesday afternoon that it would downsize its research to focus on its lead The move comes less than three weeks after X4 pulled together a $55 million PIPE and amended a loan facility

June 2022 "We’re delighted to welcome Dr Ed Brennan as our new Vice President, Head of Clinical Development He has led teams that have filed more than 10 Investigational New Drug Applications (IND), as well as In 2007 he formed IndiPharm which was a full-service Contract Research Organization whose operational headquarters were in Mumbai, India. He went on to study medicine at the Royal College of Surgeons in Ireland before receiving his Medical

April 2022 John Streicher talks about his work on terpenes found in cannabis as these may be a novel way to treat pain without the negative side effects "Many people are familiar with cannabis, but John These compounds may be a novel way to treat pain without the negative side effects of cannabinoids or

January 2022 "We are an experienced, innovative, global team on a bold mission to improve health by creating and developing life-changing medicines for people around the world."

receptor CXCR4 WHIM syndrome is a rare immunodeficiency disorder that is characterized by warts, hypogammaglobulinemia Here, we report on a new WHIM syndrome mutation that results in a frame shift within the codon for Ser339 (S339fs5) and compare the properties of S339fs5 with wild type CXCR4 and a previously identified WHIM In contrast to wild type CXCR4, both R334X and S339fs5 were largely insensitive to CXCL12-promoted degradation Moreover, while basal and agonist-promoted degradation of wild type CXCR4 was effectively inhibited by

Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water flea are considered to have originated from early evolution of eukaryotic species, therefore, the genome-wide Here, we identified a total 216 full-length GPCR genes in the marine water flea Diaphanosoma celebensis genome, which were classified into five distinct classes (A, B, C, F, and other). purinergic and chemokine receptors were highly differentiated in humans.

Elizabeth Johnstone were awarded one of the 2022 Diabetes Research Grants at the World Diabetes Day Breakfast "Congratulations to Perkins Professor Kevin Pfleger and Dr Elizabeth Johnstone who were awarded one of the 2022 Diabetes Research Grants at yesterday's annual World Diabetes Day Breakfast! This $60,000 grant from Diabetes Research WA will assist the Perkins' Molecular Endocrinology and Pharmacology Laboratory team who are investigating new ways to tackle the disease-inducing chronic inflammation that

March 2022 "Congratulations to Richard J. Law, our newly named Chief Business Officer. Richard is the architect behind nearly all of Exscientia's partnerships and collaborations across pharma and #biotech⁠ and is an advocate for the role of #AI in drug discovery." Read more at the source #DrGPCR #GPCR #IndustryNews