Brian is involved in organizing the GRC/GRS Molecular Pharmacology meeting, which has been postponed

Fung has spent significant time in the industry studying membrane proteins, antibodies, and HTS methods

She began her Ph.D. at Imperial College London with Prof Aylin Hanyaloglu, Prof Gary Frost, and Dr. Outside the lab, she enjoys baking and swimming and has recently taken up paddle boarding.

Engelenburg1, Joost Smolders1,3, and Jörg Hamann1,2 1Department of Neuroimmunology, Netherlands Institute Experimental Medicine, Institute for Biocehmistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf elucidating novel mechanisms by which β-adrenergic receptors impact cardiac structure and function, and has Additionally, the lab has begun to investigate potential roles for previously unrecognized cardiac-expressed

Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received However, the association between ARDS and RGS6 has not been reported.

Mexican folklore AND contain adhesion GPCRs Avoid copyrighted material unless a CC BY / open-use license has

These studies have revealed new and unexpected ways for membrane lipids to regulate GPCR activity and More recently, Ben’s lab has begun studying GPCR signaling pathways that operate within the primary cilium

In April 2009, he joined the Department of Pharmacology and Toxicology at University of Toronto and has

., is our co-founder and has served as our President and Chief Executive Officer since December 2008.

His research team has pioneered the study of G proteins and G protein coupled receptors (GPCRs) in human

She has advanced the use of computational methods to meet the challenges of designing therapeutics with

He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus

Massive synapse loss in the prefrontal cortex is a hallmark of massive depressive disorder. Restoration of synaptic connections induced by low-dose ketamine has been found associated with the sustained particular, drives tumor growth via effects on GBM stem cell self-renewal and metabolism, but also has His group has been particularly interested in the role adhesion GPCRs play in glioblastoma biology and Nicole Perry-Hauser on the web LinkedIn Research Gate Pubmed Dr.

Brain angiogenesis inhibitor 3 (BAI3/ADGRB3), a member of the BAI1-3 subfamily of adhesion GPCRS, has this observation has not been explored. However, while its sister protein BAI1 has demonstrated tumor suppressor functions in the brain, it remains The cleaved BAI1 isoform has a 19 amino acid extracellular stalk that can serve as a receptor agonist This regimen has long lasting side-effects, including neuroendocrine and cognitive problems, and ~ 30%

He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and

Aaron has a proven track record as a biologics leader as he led teams to discover and develop novel first-in-class

Since 2019, Nick has combined his university role with the leadership of Excellerate Bioscience as Chief

A defining hallmark of GBM is a highly acidic tumor microenvironment, which is thought to activate pro-tumorigenic Usage of Lorazepam, which has off target agonism of GPR68, is linked to worse clinical outcomes for a However, the role of tumor microenvironment acidification in GPR68 activation has not been assessed in

Senthil Muthuswamy at Cold Spring Harbor Laboratory and probed the roles of polarity proteins (Feigin Mike's lab has two main areas of interest: 1) alternative polyadenylation as a targetable driver of pancreatic Teamwork and Flexibility in Scientific Research Mike shared about his recent promotion and the way he has Mike also shared about a drug that targets an enzyme involved in mRNA cleaving, which has been found Mike shared his team's current focus on alprazolam, an anti-anxiety medication that has unexpected effects

He has a background in biochemistry from the Free University in Berlin/Germany and a Ph.D. in molecular

FB’ team has identified the orphan CXCR7/ACKR3 receptor as being the 2nd receptor for CXCL12, which behaves

Abstract "Recent progress in elucidating the role of specific antidiuretic hormones in Drosophila models has Authors Meng Wang, Yong Han, Chao Zhang Source Contribute to the GPCR News Coming soon Become a Contributor

At McGill, his laboratory has two main axes of research: 1) Studying interindividual vulnerability to

He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and

In 2018 he joined the University of Copenhagen, where he has received an ERC Starting Grant, Lundbeck

Protein-Coupled Receptors Fabian Pohl Abstract "The GPCR autoproteolysis-inducing (GAIN) domain is a hallmark CELSRs have large and enigmatic extracellular regions (ECRs) with nine cadherin repeats and a variety The autoproteolytic mechanism has been previously proposed, but remains to be validated.⁠ A previous computational study has uncovered variable flexible protein regions, whose dynamics mediate Institute of Bioanalytical Chemistry, Leipzig University, Germany" About Florian Seufert "Florian Seufert has

Inês Pinheiro PharmD by training and Ph.D. candidate in Hartley's lab at the University of Geneva. Research Associate at IQVIA and regulatory officer at the Food and Drug Authority (FDA) in Ghana, John has Since beginning her undergraduate studies, she has used computational methods like molecular dynamics

Subsequent work has focused on understanding the molecular basis of GPCR pharmacology through structure Structures have been determined by X-ray crystallography of receptors coupled to either mini-Gs or mini-Go