Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy . Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for therapeutic interventions, including monoclonal antibodies, CAR-T cells, and T-cell engagers. Liu, Fei Xu Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

human protein atlas database, we inferred the most predominant GPCR-mediated microbial metabolite-human cell permeability of the small-molecules we elucidated their molecular interactions with specific human cell receptors, particularly expressed on human intestinal epithelial cells, immune cells and the nervous Metabolites Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Individual cells trend to adapt environmental changes in a "whole" flora through communications, allowing Furthermore, GprC and AcyA regulate the primary metabolism as well as secondary metabolism, and further These studies highlight a crucial G protein signaling pathway for cell communication that is mediated ochraceus, hoping to achieve comprehensive prevention and control of mycotoxin pollution from interrupting cell Authors Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication

heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell disrupted their engagement with GIV/Girdin, thereby blocking noncanonical G-protein signaling in tumor cells and inhibiting proinvasive traits of metastatic cancer cells. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Here, we showed that US28 increased the malignancy of U251 glioblastoma cells by enhancing signaling Enhanced S1P signaling promoted glioblastoma cell proliferation and survival by activating the kinases US28 also activated the S1P signaling axis in HCMV-infected cells. Authors Nick D Bergkamp , Jeffrey R van Senten , Hendrik J Brink , Maarten P Bebelman , Jelle van den Martine J Smit Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

MM) is a complex hematological malignancy characterized by abnormal antibody production from plasma cells G-protein-coupled receptor class C group 5 member D (GPRC5D), an orphan GPCR predominantly expressed in MM cells Talquetamab, a Food and Drug Administration-approved T-cell-directing bispecific antibody developed for talquetamab Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

., PNAS, 2014) in breast cancer pathogenesis, using mouse models, three-dimensional cell culture and Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its He also discussed the impact of disrupting histone processing on rapidly proliferating cells, such as cancer cells, and suggested a therapeutic index for a drug called JTE-6.7. He also discussed his experiments and discoveries about GPR161 in mammary epithelial cells, the effect

elevated in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell studies in mice, we show that GPR143 promotes metastasis by secreting exosomes and increasing cancer cell provide a mechanism for regulating the exosomal proteome and demonstrate its ability to promote cancer cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Furthermore, fibroblasts abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages in the fibrotic lung. GPR176 expression was unaffected by TGFβ1 stimulation in rat renal fibroblast NRK-49 cells, whereas knockdown of Gpr176 by siRNA reduced TGFβ1-induced expression of αSMA, fibronectin, and collagen as well as Smad2 GPCR , TGFβ1 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

treating patients suffering from lung cancer is to target surface receptors overexpressed on tumor cells cancers, such as prostate and ovarian cancer, facilitating the invasive and metastatic capacity of tumor cells The expression levels of KLKs in this neoplasm are modulated by the secretome of the different cell types SARS-CoV-2 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

cancer therapy Published date September 12, 2024 Abstract "G protein-coupled receptors (GPCRs) are vital cell highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity, cancer cell Treatment Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Immunology Itaconate in host inflammation and defense Published date March 5, 2024 Abstract "Immune cells Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory itaconate Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune cell Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Replication by Regulating Ca2+ Flux Published date May 29, 2023 Abstract "Chemokine production by epithelial cells coronavirus porcine epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Laboratories cell-porcine kidney 1 epithelial cells (LLC-PK1). Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Promotes Osteogenic Differentiation Published date May 30, 2023 Abstract "Objectives: Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cell possessing self-renewal and multilineage differentiation Materials and methods: The viability and apoptosis of human DPSCs (hDPSCs) were determined using Cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling pathways in immune cells His laboratory uses knock-out and transgenic mouse models, along with different cell culture systems, to understand the role of immune cell GPCRs and their cross-talk with other insulin-sensitive tissues Sai Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research

G protein-coupled receptors (GPCRs) are involved in endocrine and metabolic processes as well as many increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation in 3T3-L1 cells Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

This activation promotes neurogenic differentiation of neural stem cells, neurite growth, and synaptogenesis Under nutrient depletion, the model choanoflagellate Salpingoeca rosetta forms distinct cell types that We found that the knock-out of cupidon induces a gain in cell adhesion and cell fusion, resembling the mating behavior of wild-type cells under nutrient depletion. Cupidon mutants, similar to starved wild-type cells, upregulate various extracellular matrix-related

roles of AGPCRs in the periphery ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells health and disease Douglas Tilley ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells Centre for Experimental Medicine, Institute for Biocehmistry and Molecular Cell Biology, University Medical Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2012 - 2015 Postdoctoral fellow, Department of Cell impact cardiac structure and function, and has evolved to encompass their roles in regulating immune cell

polarity (PCP) pathway, which establishes and maintains cell and tissue polarity along the tissue plane We initially tested the ADC using in vitro WST-8 viability assays in human GBM cell lines and cell types We observed significantly lower LD50 values in patient-derived and U87 GBM cell cultures vs. CD97-lacking cells. We also found significantly lower LD50 values when treating human GBM cells with the ADC (0.6788 nM),

research interests lies in the elucidation of signal transduction pathways in cancer, immune and bone cells area of interest has been the elucidation of the molecular basis for a rare autosomal human disease called The Rottapel lab has shown that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell

Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used , RNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

controlling their steady state trafficking and sometimes their agonist-induced internalisation, as well Norbin in the trafficking of endogenous C5aR1 and CXCR4 in primary neutrophils by flow cytometry and cell β-arrestin-dependent mechanism and limits the recycling of internalised C5aR1 and CXCR4 back to the cell C5a-stimulated membrane translocation of Tiam1, Vav, and PKCδ, and activation of Erk and p38 Mapk pathways, as well β-arrestin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Authors Anna B Halpern , Eduardo Rodríguez-Arbolí , Megan Othus , Kelsey-Leigh A Garcia , Mary-Elizabeth Vivian G Oehler , Pamela S Becker , Jacob S Appelbaum , Janis L Abkowitz , Johnnie J Orozco , Siobán B Keel , Paul C Hendrie , Bart L Scott , M Cristina Ghiuzeli , Elihu H Estey , Roland B Walter Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry

of Technology in Genova, Italy (2008-2016) and an Associate Research Professor in the Department of Cell Before joining the Department of Cell Biology in 1996 as a postdoc and becoming faculty at Duke in 2000 As of August 2022, he has over 270 publications in scientific journals (including Science, Nature, Cell

GPCR Ecosystem About Monserrat Avila Zozaya I am a cell biologist interested in studying GPCRs, especially developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

Yuling Feng The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell Stephen, Caron Kathleen M Department of Cell Biology and Physiology at UNC Chapel Hill 111 Mason Farm Van Meir’s research examines how genetic alterations and hypoxia induce changes in cell biology that To address these gaps in knowledge, we used biochemical and cell-biological approaches using cell-lines