Results demonstrate that the activity of either G protein-coupled receptor system must be considered

to strikingly long in vitro receptor occupancy durations (at least seven days), meaning that lengthy pharmacodynamic 11. https://doi.org/10.1126/scitranslmed.aav5519 · Demonstration of the in vivo efficacy of a systemically

chronic immune-mediated disease in which the immune responses are almost run against the central nervous system

Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis "The sympathetic nervous system

ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system

related behaviors Methods & Updates in GPCR Research Functional GPCR expression in eukaryotic LEXSY system

Although less characterized, canonical chemokine receptor systems have been also shown to not only directly However, it is important to note that this scavenging role does not occur in all chemokine receptor systems

Their abundance and role in nearly all physiological systems make GPCR the largest protein family targeted

GPCR Signaling Measurement and Drug Profiling with an Automated Live-Cell Microscopy System.

GPCR Binders, Drugs, and more Molecular Characterization of Two Wamide Neuropeptide Signaling Systems

GPCR Signaling Measurement and Drug Profiling with an Automated Live-Cell Microscopy System.

Structural genomics of the human dopamine receptor system Structural Insights into Molecular Recognition

GPCRs in Cardiology, Endocrinology, and Taste Discovery of paralogous GnRH and corazonin signaling systems

species with an engineered sensor A Multi-Angle Approach to Predict Peptide-GPCR Complexes: The N/OFQ-NOP System

The Neuromedin U system: pharmacological implications for the treatment of obesity and binge eating behavior

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems.

developing new treatments for these disorders and advancing our understanding of the brain and nervous system

Reviews, GPCRs, and more Internal and external modulation factors of the orexin system (REVIEW).

receptor, forms oligomers GPCR Activation and Signaling Unraveling the crosstalk between renin-angiotensin system

Internal and external modulation factors of the orexin system (REVIEW).

small molecules against cannabinoid 2 receptor (CB2R) Ketone bodies as chemical signals for the immune system

Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System

more ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

pluripotent stem cell-derived nociceptive-like neurons Characterization of myoinhibitory peptide signaling system

through phenotypic profiling in C. elegans Reviews, GPCRs, and more Classifying tetraspanins: A universal system

Activity Models of Key GPCR Families in the Central Nervous System: A Tool for Many Purposes.

challenges, including expensive cost of reagents, optimizing sensor expression levels and adapting these systems

Nbs are useful tools for dynamic biological systems; they have been used to crystallize flexible membrane