protein-coupled receptor (GPCR) kinases (GRKs) are associated with the pathophysiology of Alzheimer's disease

sites of GPCRs for drug discovery Targeting mGluR group III for the treatment of neurodegenerative diseases Methods & Updates in GPCR Research Advancements in the use of xenopus oocytes for modelling neurological disease

Sir William Osler Scientists have long sought to discover a “golden bullet” that would cure every disease The more we know about the pathology of diseases, the more complicated it is to modulate them by a specific

intracellular protein complexes and solute carriers, are relevant to immunology indications and rare diseases

important drug targets, and numerous drugs that modulate GPCRs are already in clinical use for various diseases Drug repurposing: AI algorithms can screen existing drugs and repurpose them for GPCR-related diseases By analyzing drug-target interactions and disease pathways, AI can identify potential candidates that Towards a comprehensive understanding of GPCRs, ligands, diseases, and their associations: open-access

Neuroscience Diverse signaling mechanisms and heterogeneity of astrocyte reactivity in Alzheimer's disease Sosei Heptares and Kallyope Nominate First GPCR Target for Therapeutic Development in Gastrointestinal Diseases

disaccharide sugar with known pro‐autophagy activity and effective in alleviating diverse inflammatory diseases

GPCRs in Cardiology, Endocrinology, and Taste Gender Differences in GRK2 in Cardiovascular Diseases and Manager Director of Molecular Pharmacology, Discovery Biology Staff Scientist/Senior Staff Scientist, Disease

Neisseria meningitidis is a Gram-negative opportunistic pathogen that is responsible for causing human diseases

protein-coupled A2A adenosine receptor (A2AAR) have been considered promising agents to treat Parkinson's disease

Principles of Pharmacology II October 31, November 7, 14, 21, December 5 (five sessions) (we skipped GPCR-Mediated Natural Products and Compounds: Potential Therapeutic Targets for the Treatment of Neurological Disease

cellulose-degrading enzymes Functional Water Channels Within the TSH Receptor - a new paradigm for TSH action with disease launch LAB eN², a translational drug discovery accelerator, to address innovation gap in cardiometabolic diseases

macrophages and monocytes, and play a critical role in neuroinflammatory conditions such as Alzheimer's disease

Molecular Endocrinology and Pharmacology Laboratory team who are investigating new ways to tackle the disease-inducing

numerous GPCRs have been studied for their impact on pathologic conditions, including cardiovascular diseases

Endocrinology, and Taste The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory diseases cancer and inflammation AVROBIO and Tectonic Therapeutic Announce Merger Trevena Inc Elevates Barry Shin

Retinitis pigmentosa (RP) is a group of hereditary degenerative diseases affecting 1 of 4000 people worldwide

with the fact that dysregulation of compartmentalized GPCR signaling has been implicated in various diseases aberrant endosomal signaling by GPCRs has been linked to disorders such as cancer, neurodegenerative diseases Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases

Several S1PR therapeutic drugs have been developed to treat these diseases; however, they lack receptor

effects of CB2 receptor activation, make this receptor an intriguing target for treating schizophrenia, a disease

(GPCR) targets with a goal of creating new drug discovery programs in the area of gastrointestinal diseases

understanding the modulatory role of the membrane environment on the organization and dynamics of GPCRs in diseases

Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer's and Parkinson's diseases as druggable targets through Withania somnifera bioactives: an in silico study

phases of clinical development, and across multiple therapeutic areas, including Oncology, Infectious Diseases

determines the potential of a GPCR for arrestin-biased agonism The roles of RGS proteins in cardiometabolic disease Receptor Responses to Sequential Injections of Pure and Mixed Sweeteners GPCRs involved in metabolic diseases

The mGlu5 receptor is a promising target for the treatment of psychiatric and neurodegenerative diseases

fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range of diseases

protein-coupled receptors (aGPCRs) are keys of many physiological events and attractive targets for various diseases