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119 items found for "Lumpy skin disease"
- Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer
second area of interest has been the elucidation of the molecular basis for a rare autosomal human disease
- Atypical Structure and Function of Typical Chemokine Receptors
Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing
- Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer
small molecules can selectively disable noncanonical mechanisms of G-protein activation dysregulated in disease
- Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling
were shown to be very effective to rescue the cell death observed in a mouse model of Huntington’s disease
- In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity
essential in regulating GPCR signaling, and most members are implicated as critical nodes in human diseases
- Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling
Conclusions: Antagonizing the NPYRs has been implicated as a treatment for a wide variety of diseases
- Ep 132 with Dr. Richard Premont
where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease
- Ep 130 with Dr. Richard Premont
where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease
- Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer
cancer Published date June 24, 2024 Abstract "Pancreatic ductal adenocarcinoma (PDAC) remains a dreadful disease
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
the C5aR1, which has received enormous attention for its role in both acute and chronic inflammatory diseases
- Ep 133 with Dr. Richard Premont
where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease
- Ep 42 with Dr. Randy Hall
Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb
- Ep 131 with Dr. Richard Premont
where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease
- Session VI | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Initial impairment of synaptic functions, which occurs early in Alzheimer’s disease, and subsequent massive My research focus is the mechanisms of neural circuit development, function and disease."
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
prenylation contributes to multiple disorders, including cancers and vascular and neurodegenerative diseases
- The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
Published date November 3, 2023 Abstract " Purpose: Peripheral T-cell lymphoma (PTCL) is an aggressive disease
- Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts
Abstract " Background and purpose: Activated fibroblasts deposit fibrotic matrix in chronic kidney disease
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
Published date November 1, 2022 Abstract Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive disease
- Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer
primarily due to the lack of early diagnostic tools, effective targeted therapy, and clear understanding of disease
- A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages
Potential role of GPR109A in macrophages Published date September 2, 2024 Abstract "Inflammatory Bowel Disease
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
Ram, Gauri Ganesh, Misun Kang, Sunita Ho, Edward C Hsiao Tags Wnt pathway inhibition , fibrotic bone disease
- Ep 47 with Dr Simone Promel Dr Ines Liebscher
there was not much known other than that they are huge and somehow play important roles in health and disease
- Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq
Patients with ERα-positive/PR-negative tumors have shorter disease-free and overall survival than patients
- Ep 155 with Endocrine Metabolic GPCR Organizers
cellular mechanisms by which mutations in a chloride-proton antiporter cause the renal disorder Dent’s disease
- Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux
and more effort is needed to develop economical and efficient vaccines to control or eliminate this disease
- Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Published date December 8, 2023 Abstract " Background: Acute respiratory distress syndrome (ARDS) is a disease
- Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
"Background: Neuroinflammation is a widely studied phenomenon underlying various neurodegenerative diseases
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
Genetic variants in RGS proteins are associated with many diseases, including cancers, although the impact
