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309 items found for "Molecular biology"
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
with receptors at the molecular level. Notably, innovations in structural biology, such as X-ray crystallography and cryo-electron microscopy While advancements in structural biology techniques like X-ray crystallography and cryo-electron microscopy Molecular determinants of ligand efficacy and potency in GPCR signaling. Molecular Pharmacology , 90 (6), 703-714.
- GPCR Updates: Celebrating Breakthroughs, New Course Launches Soon, and Exclusive Discounts! | Aug 26 - Sep 1, 2024
Mexico City 📅 October 23-25, 2024 Join us to connect with peers and explore the latest in adhesion GPCR biology Highlighting ADS024 a Novel Oral Agent for Neuroinflammation Call for GPCR Papers Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Webinars September 5 - 6, 2024 Clinical Pharmacology GPCR Jobs HIGHLIGHT Research Associate - Professor Graeme Milligan NEW Postdoc in Molecular rogue: mechanisms, regulation, and roles of mutationally activated Gα in human cancer Structural and Molecular
- 📰 GPCR Weekly News, December 18 to 31, 2023
Franziska M Heydenreich, Michel Bouvier, Brian Kobilka, M Madan Babu, and their team's work on Molecular Protein-Coupled Receptors (GPCRs) Associated with Lambda-Cyhalothrin Detoxification in Cydia pomonella Molecular - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Scientist NEW Principal Investigator, In Vitro Biology
- 📰 GPCR Weekly News, January 29 to February 4, 2024
Dimitrios Stamou, et al. for their work on the Molecular mechanism of GPCR spatial organization at the plasma membrane, featured on the cover of Nature Chemical Biology Julia Kinsolving; Dr. Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Fellowship- Mechanistic Biology NEW Research Scientist Post-Doc position Lead Researcher Senior Researcher in Structural Biology Post-Doctoral
- 📰 GPCR Weekly News, May 27 to June 2, 2024
for this exciting event, which unites scientists worldwide to explore all aspects of adhesion GPCR biology receptor heteromer in dopaminergic neurons A new GRAB sensor reveals differences in the dynamics and molecular agonist's efficacy Single transmembrane GPCR modulating proteins: neither single nor simple Structural and Molecular Data from its Phase 2a Obesity Study and Capsule to Tablet PK Study for its Oral Non-Peptide Small Molecule Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell Biology
- 📰 GPCR Weekly News, April 3 to 9, 2023
The molecular basis of the antidepressant action of the magic mushroom extract, psilocin. Structural and Molecular Insights into GPCR Function Sub-millisecond conformational dynamics of the A2A SLAS 2023 Building Biology in 3D Symposium. (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023). Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.
- 📰 GPCR Weekly News, February 5 to 11, 2024
, and more The dark sides of the GPCR tree - research progress on understudied GPCRs Structural and Molecular Hormone Type 1 Receptor Activation in Class B1 G Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, Imaging Center NEW Scientific Assistant Postdoctoral Fellowship- Mechanistic Biology Research Scientist
- 📰 GPCR Weekly News, May 6 to 12, 2024
this fabulous event that brings together scientists worldwide working on all aspects of adhesion GPCR biology in GPCR Research ONE-GO: Direct detection of context-dependent GPCR activity Author Correction: GPCR molecular cooperative GPCR:G protein interactions that contribute to G protein coupling Reviews, GPCRs, and more Molecular Lipid mediators in neutrophil biology: inflammation, resolution and beyond Exploring GPCR signaling comprehensive GPCR-transducer-deficient cell lines to dissect complexity of GPCR signaling Structural and Molecular
- 📰 GPCR Weekly News, August 28 to September 3, 2023
receptor, and renin-angiotensin system autoantibodies: Systematic review and meta-analysis Structural and Molecular 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10 Exhibition June 2 - 4, 2024 | Chemotactic Cytokines GPCR Jobs Researcher / Senior Researcher in Structural Biology Associate Postdoc Research Associate Director, Regulatory Affairs Research Scientist/Senior Scientist I - Molecular
- 📰 GPCR Weekly News, November 20 to 26, 2023
Tobias Langenhan for his papers to highlight suggestions GAIN Domain Unfolding in Adhesion GPCRs Molecular Severity Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs Molecular characterization of lumpy skin disease virus from recent outbreaks in Pakistan Structural and Molecular - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4,
- 📰 Breaking Down the Latest GPCR Discoveries: a Weekly Update (Nov 27-Dec 3, 2023)
receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological optogenetic applications Imaging flow cytometry of tumoroids: A new method for studying GPCR expression GPCR molecular olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review) Structural and Molecular - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4,
- 📰 GPCR Weekly News, May 22 to 28, 2023
Structural and Molecular Insights into GPCR Function Cholesterol Biases the Conformational Landscape of the Chemokine Receptor CCR3: A MAS SSNMR-Filtered Molecular Dynamics Study. Molecular mechanism of fatty acid activation of FFAR1. (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023). Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.
- 📰 GPCR Weekly News, May 8 to 14, 2023
GPCR Binders, Drugs, and more In-depth molecular profiling of an intronic GNAO1 mutant as the basis for GPCRs in Cardiology, Endocrinology, and Taste Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling Structural and Molecular Insights into GPCR Function New Insights into the Structure and Function of (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023). Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.
- Dr. GPCR University registration is now open! Secure your spot now!
and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Connect with fellow scientists and dive into the latest in adhesion GPCR biology. Microscopy of Wild-Type Receptors Structural and Molecular Insights into GPCR Function Vibrational Energy to Advance a Pipeline of Novel GPCR-Modulating Therapies into Clinical Development How To Discover Biologics September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery October 2024 | Biologics
- Dynamic GPCR activation revealed through time-resolved Cryo-EM
This research not only deepens our understanding of a key biological process but also provides a valuable and underscores the importance of understanding cellular processes at the molecular level for therapeutic Beyond GPCRs, the methods and insights from this study can be applied to other fast, transient biological This approach is valuable for understanding the dynamics of other complex signaling pathways and molecular interactions, offering a deeper understanding of cellular processes at the molecular level.
- 📰 GPCR Weekly News, October 23 to 29, 2023
extracellular calcium pathways Versatile lactate signaling via HCAR1: a multifaceted GPCR involved in many biological 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10 vitro pharmacology - Crinetics Pharmaceuticals In vivo Antibody Discovery Research Scientist In Vitro Biologist /Molecular Pharmacologist Explore Dr.
- 📰 GPCR Weekly News, October 2 to 8, 2023
: Duke leaders talk success, failure at symposium honoring Nobel Laureate Robert Lefkowitz Integral Molecular 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10 vitro pharmacology - Crinetics Pharmaceuticals In vivo Antibody Discovery Research Scientist In Vitro Biologist /Molecular Pharmacologist Senior Vice President, Oncology Clinical Research Scientist (level I or II)
- 📰 GPCR Weekly News
Structural and Molecular Insights into GPCR Function Computational investigation of functional water Molecular insights into the mechanism of sugar-modified enkephalin binding to opioid receptors. Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology. June 4-8,2023. 2023 Molecular Pharmacology (GRS) Seminar GRC. June 10 - 11. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.
- 📰 GPCR Weekly News, February 12 to 18, 2024
Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Research Fellow NEW Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director of Laboratory Operations - Single-molecule Imaging Center Scientific Assistant Postdoctoral Fellowship- Mechanistic Biology Research Scientist Post-Doc position
- 📰 GPCR Weekly News, September 18 to 24, 2023
of salivary intercalated duct cells reveals a secretory phenotype Mesenchymal stromal cell secretory molecules GPCRs, and more The discovery, structure, and function of 5-HTR1E serotonin receptor Structural and Molecular 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10 Technician Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals Postdoc In Cell Biology
- 📰 GPCR Weekly News, January 15 to 21, 2024
Advanced biophysical and biochemical technologies to study GPCR signal transduction Structural and Molecular Meeting NEW March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, Pharmacology 2026 GPCR Jobs NEW Post-Doc position NEW Lead Researcher Senior Researcher in Structural Biology Fellow Research Laboratory Specialist Associate Postdoctoral Scientist Principal Investigator, In Vitro Biology
- 📰 GPCR Weekly News, May 15 to 21, 2023
Our next symposium is on July 21st, 2023, focusing on Structural and Molecular Insights into GPCR Activation of the Human Growth Hormone Secretagogue Receptor Reveals Insights into the Energy Landscape of the Molecule (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023). Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
Based on an ingenious combination of multicolor single-molecule microscopy approach with molecular dynamics However, the evidence obtained in this study proposes novel molecular mechanisms in which β-arrestin Read the complete article here: https://www.ecosystem.drgpcr.com/gpcr-binders-drugs-and-more/in-depth-molecular-profiling-of-an-intronic-gnao1 Molecular mechanism of GPCR-mediated arrestin activation. Molecular mechanism of b-arrestin-biased agonism at seven-transmembrane receptors. Annu. Rev.
- 📰 GPCR Weekly News
Protein-Coupled Receptor Reviews, GPCRs, and more Life, death and resurrection of plant GPCRs Structural and Molecular Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology. June 4-8,2023. 2023 Molecular Pharmacology (GRS) Seminar GRC. June 10 - 11. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.
- 📰 GPCR Weekly News, January 30 to February 5, 2023
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards Structural and Molecular Insights into GPCR Function Structural view of G protein-coupled receptor signaling SLAS 2023 B uilding Biology in 3D Symposium. (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023). Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.
- 📰 GPCR Weekly News, June 10 to 16, 2024
Join us in vibrant Mexico City from October 23 to 25, 2024, for this key event in adhesion GPCR Biology therapeutics in targeting G protein-coupled receptors: Recent advances and challenges Structural and Molecular Phosphorylation and G-Protein Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell Biology
- 📰 GPCR Weekly News, October 16 to 22, 2023
resonance energy transfer to quantitate cell-surface expression of membrane proteins Structural and Molecular Insights into GPCR Function Molecular property, manipulation, and potential use of Opn5 and its homologs Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10 vitro pharmacology - Crinetics Pharmaceuticals In vivo Antibody Discovery Research Scientist In Vitro Biologist /Molecular Pharmacologist Senior Vice President, Oncology Clinical Research Scientist (level I or II)
- 📰 GPCR Weekly News, March 13 to 19, 2023
A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice. Structural and Molecular Insights into GPCR Function Structural basis of selective cannabinoid CB2 receptor (March 30, 2023) SLAS 2023 Building Biology in 3D Symposium. (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023). Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.