Search Results
283 items found for "Molecular diversity"
- From odor to oncology: non-canonical odorant receptors in cancer
associated with olfaction as chemoreceptors, have been increasingly recognized for their presence and diverse Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells
29, 2024 Abstract "The intestinal lumen is rich in gut microbial metabolites that serve as signaling molecules Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis
identified a previously unknown GPCR-mediated malignant progression and translated sensors of viral molecules Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells
protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling molecules Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure in mice
Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
activation by 8GL promoted differentiation and reduced colony formation in human AML cell lines with diverse Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Dr. GPCR Community Presentation | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
My research focuses on understanding the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
The current study aimed to identify molecular predictors of response to ONV + DAC in R/R AML patients Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
Alterations in complex cellular phenotype each typically involve multistep activation of an ultrasensitive molecular Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
the roles of GPR81 in three-dimensional (3D) and in vivo growth of breast cancer cells and study the molecular Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Interrogating Multiscale Receptors Functions in Space
Beaulieu’s research is aimed at understanding how cellular and molecular mechanisms regulated by psychoactive These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular
- Identification of a G-protein coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis
Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled receptor , Immune infiltration , Molecular Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning
Authors Chenshen Huang , Fengshuo Zhu , Hao Zhang , Ning Wang , Qi Huang Tags Cancer , Machine learning , Molecular Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
William , Chih-Yang Wang Tags G-protein-coupled receptor (GPCR) , genome , glioblastoma , malignancy , molecular Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Ep 47 with Dr Simone Promel Dr Ines Liebscher
During this time, she discovered her love for Adhesion GPCRs and started delineating the molecular mechanisms and her team are working on the questions of how Adhesion GPCRs integrate the different signals on a molecular
- Ep 97 with Robert Laprairie
The focus of his research is the molecular pharmacology of cannabinoids and cannabinoid receptors.
- Ep 08 with Dr. Graciela Pineyro
She has done extensive work on the molecular pharmacology of opioid receptors and is currently focusing
- Ep 135 with Dr. Katarzyna Marcinkiewicz
which she joined in April 2020, following three years on the editorial teams of Nature Structural and Molecular
- Ep 23 with Dr. Qing Fan
Qing is a structural biologist interested in the molecular mechanisms controlling how class C GPCRs transmit
- Ep 44 with Dr. Steven Foord
He introduced molecular pharmacology to a wide range of the company's GPCR projects and was able to initiate
- Ep 26 with Dr. Debbie Hay
Debbie obtained a Ph.D. in Molecular Pharmacology from Imperial College London in the UK.
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
cilia orchestrates tissue organization-especially, the role of cilia-generated effectors in mediating diverse rationalization of different modes of signaling generated by the primary cilium in mediating morphogenesis in diverse Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway
G protein-coupled receptor (GPCR) signalling transduction, and in particular, function of adhesion molecule Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design
January 22, 2024 Abstract "Studying primordial events in cancer is pivotal for identifying predictive molecular Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Ep 145 with Dr John Janetzko
There, I’ve been working towards understanding the molecular basis of G protein-coupled receptor desensitization several techniques including various mass spectrometry approaches, single particle cryo-EM and single-molecule Colorado, Anschutz Medical Campus, as an Assistant Professor in the Department of Biochemistry and Molecular The conversation emphasized the importance of diverse backgrounds and skill sets in tackling complex building milestones and landmarks into a postdoc, such as applying for funding opportunities, and getting diverse
- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
This study shows that cancer-associated mutations of 5-HT2C receptor have diverse effects on ligand binding Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular
- Ep 07 with Dr. Paul Insel
of numerous scientific journals, including but not limited to the Journal of Clinical Investigation, Molecular
- Ep 04 with Dr. Graciela Pineyro
Graciela has done extensive work on the molecular pharmacology of opioid receptors, exploring their signaling