Postdoctoral Position Postdoctoral research position Adhesion GPCRs The G Protein-Coupled Receptor GPR56 Is an Inhibitory

Parent, et al. 2001), inhibition of clathrin-mediated endocytosis (CME) did not affect the ability of CCR2 inhibition leads to inhibition of scavenging and elevated plasma levels of CCL2 (Y.

interferon genes (STING) signaling pathway has been implicated in organ injuries and its activation inhibits

We identify nanobodies that stimulated lipid kinase activity, block Ras activation, and specifically inhibited

In fibroblasts, OGR1 inhibits myofibroblast differentiation and does not contribute to inflammation.

The results show that the combination of pGRP with PTK2 inhibition or of pGRP with pCIB > pCIBm in additive

AYPGKF peptide ligand activation of PAR4 induces EGF receptor (EGFR) Tyr-phosphorylation, effectively inhibited

O-glycosylation and tyrosine sulfation on CCR5 and CCR1 function In this study engineered cell lines, inhibitors

Moreover, while basal and agonist-promoted degradation of wild type CXCR4 was effectively inhibited by

potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth

In the absence of HH signaling, SMO is inhibited by Patched 1 (PTC1; a 12 pass transmembrane domain protein

Structural and Molecular Insights into GPCR Function Structural and functional analyses of a GPCR-inhibited

Allosteric modulators offer a promising approach for developing drugs that enhance or inhibit receptor

and Taste Blockade of endothelial adenosine receptor 2A suppresses atherosclerosis in vivo through inhibiting

Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting

Instead, G12 overexpression inhibited V2R downstream signalling, including β-arrestin recruitment and

Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited

GPCR Activation and Signaling Statins inhibit protein kinase D (PKD) activation in intestinal cells and

environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition

Oncology and Immunology Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting

2024 GPCR Activation and Signaling GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting

new paradigm for TSH action with disease implications GPCRs in Oncology and Immunology LPA1-mediated inhibition

involves Na+/K+ ATPase GPCR Promiscuity Reshapes Islet Physiology TGR5 supresses cGAS/STING pathway by inhibiting

of antagonists of the tick (Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit

Immunology RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition

also engage other G proteins, such as Gi/o and Gq/11, leading to different downstream effects, such as inhibition

gaps GPCR Activation and Signaling Butyrate induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition

Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. α1-adrenoceptor ligands inhibit