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M33 engages Gq/11 to constitutively activate phospholipase C β (PLCβ) and downstream cyclic AMP response-element

conformational states, which enable more efficient interactions between the GPCR and the cognate Gα C

opioid addiction A FMRFamide-like neuropeptide FLP-12 signaling regulates head locomotive behaviors in C.

immunothrombosis has become more relevant than ever, as a majority of COVID-19 patients display thrombi in the lung Furthermore, NETs can be found in the lung and other tissues and are associated with an increased mortality cytokine storm that potently activates neutrophils and leads to massive neutrophil infiltration into the lung

full control of signaling activity through a small protein GPCR via library-based screening Dorgham, K. candidate hits from library-based screening so that they can be tested in cell-based assays Akondi, K. small proteins show full in vivo efficacy in a highly stringent model of HIV transmission Steinbach, K.

Avrampou, K., et al., RGS4 Maintains Chronic Pain Symptoms in Rodent Models.

Neuroscience Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C.

Structure Therapeutics Crinetics Pharmaceuticals Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)

Sudha K Shenoy et al.

Adhesion GPCR Workshop    Location:  Mexico City Dates:  October 23-25, 2024 Join us  to connect with peers News Crinetics Pharmaceuticals Announces August 2024 Inducement Grants Under Nasdaq Listing Rule 5635(c)

alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress Two C-terminal

Crinetics Pharmaceuticals Announces November 2023 Inducement Grants Under Nasdaq Listing Rule 5635(c)

morphogenesis in evolutionarily divergent lineages GPCRs in Oncology and Immunology [1,2,4]Triazolo[1,5-c]

Pulmonary Fibrosis "Idiopathic pulmonary fibrosis (IPF) is a disease characterized by irreversible lung We demonstrate that OGR1 protein expression is significantly reduced in lung tissue from patients with

Multiple subthreshold GPCR signals combined by the G proteins Gαq and Gαs activate the C. elegans egg-laying

February 5th to 11th, 2024 GPCR Activation and Signaling Constitutive activation mechanism of a class C

Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans Reviews

a flexible N-terminus, N-loop, three anti-parallel β-strands connected by 30s- and 40s-loops, and a C-terminal Y2516.51 by CCL3 or CCL5; b) Route 2 - characterized by hydrogen bonding to E2837.39 by A4 of CCL3; c)

endothelial junctions GPCRs in Neuroscience Male-specific behavioral and transcriptomic changes in aging C.

defines complex assemblies with β-arrestin serving distinct functions Phosphorylation motif dictates GPCR C-terminal

inhibitor, suppresses the TGF-α-induced migration of hepatocellular carcinoma cells via inhibition of the c-Jun

A Perspective on Class C GPCR Based Genetically Encoded Biosensors Emergence of lumpy skin disease virus

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

multimers in human cancer cells [Inhibitory effect of downregulating G protein-coupled receptor class C

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

human islets AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung

DRD1 is exempt from TGFβ-mediated antifibrotic GPCR landscape tampering in lung fibroblasts. βHB inhibits

prefrontal cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung