Search Results

process of ligand dissociation from the receptor and shed light on the distinct durations of signaling induced

mechanisms by which Exendin-4 inhibits cardiac remodeling in remote myocardium of left ventricle MI-induced After MI, TGF-β1, and Wnt 1 levels are significantly increased, the overproduction of Wnt1 induces β-catenin Besides, TGF-β1 stabilizes cytoplasmic β-catenin levels indirectly by phosphorylation of Akt at Thr308-induced

Endocrinology and Pharmacology Laboratory team who are investigating new ways to tackle the disease-inducing

conformations has provided insights into details of local and global changes in the transmembrane domain induced

Two β3 -AR agonists are used clinically: mirabegron 1 and vibegron 2, which are indicated for overactive bladder syndrome.

analysis of gene expression, including q)RT-PCR, microarray, or relatively new NGS (RNASeq) analyses, have indicated different blood cells where aroma compounds from butter, known ligands for a variety of class I ORs, induce In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and

GPCRs in Cardiology, Endocrinology, and Taste Metabolic depletion of sphingolipids inhibits agonist-induced Identification of a potential structure-based GPCR drug for interstitial cystitis/bladder pain syndrome

A series of evidence shows that TGR5 induces protein kinase B (AKT), nuclear factor kappa-B (NF-κB),

of human islets AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced antibody Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced

from TGFβ-mediated antifibrotic GPCR landscape tampering in lung fibroblasts. βHB inhibits glucose-induced Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine

Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced Pathfndr-1 Study Evaluating Treatment Of Patients With Acromegaly Crinetics Announces September 2023 Inducement

To chemically induce CCR9 degradation, we then developed the first PROTAC targeting the IABS of GPCRs

psychedelic) substances at the serotonin receptor 5-HT2A R "Serotonergic psychedelics are substances that induce

colleagues, utilized an innovative APEX2/AUR biosensor that allows scientists to monitor the agonist-induced

Our NMR analyses demonstrated that while the C tail-mediated interaction alone induces partial activation

We showed that cGAS expression was induced in fibrotic liver and kidney, but suppressed in endothelial

Peptides did not influence GPVI-induced aggregation and Ca2+ signaling in the absence of shear.

Volinanserin (or M100907) - a 5-HT2AR antagonist - fully prevented DOI-induced HTR in male and female

produce the maximal response and can differ in intrinsic efficacy; 2) partial agonists are incapable of inducing This variability in drug effects is due to different ligands inducing unique GPCR conformations that

Although PTHrP1-36 induces transient cAMP production, acute intracellular Ca2+ (iCa2+) release and β-arrestin

extracellular region that contains various adhesion-related domains and a highly-conserved GPCR-autoproteolysis-inducing

However, KP-10 stimulation induced migration of MDA-MB-231, but not BT-20 cells, in a calcium-dependent

Phenotypic characterization suggests these mutations induce perturbation of G protein activation and/

Although melatonin by itself did not induce an initial [Ca2+]i increase and airway contraction, melatonin

Calcium-sensing receptor regulates Kv7 channels via Gi/o protein signalling and modulates excitability of human induced Vertebrate G-Protein-Coupled Receptor Fusions United With or Without an Additional Transmembrane Sequence Indicate

Sci Rep, 2016. 6: p. 28231. 14.    Pfleger, K.D., R.M. Seeber, and K.A.

structures rich in cartilaginous proteoglycans and collagens, all in the absence of differentiation inducers

Here, we investigate the conformational changes induced by the binding of a nanobody (Nb80) on the active-like