TRPM3 expression patterns differ between species and change during development.

However, a large portion of GPCR structures remain unsolved due to structural instability.

inhibitors, as these receptors primarily induce the chemotaxis of leukocytes, especially neutrophils, during

Surprisingly, RGCs in GPR3 knockout mice were vulnerable to neural death during aging without affecting

In this study, we found, for the first time, that the expression of GPR110 increased during osteoclastogenesis

through binding the EBI2 (GPR183) to stimulate effective adaptive immunity and antibody production during

"Protecting neurons from death during oxidative and neuroexcitotoxic stress is key for preventing cognitive NF-α1/CPE increased pERK 1/2 and pCREB levels which prevented a decrease in pro-survival protein, BCL2, during

During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog accumulation and myosin activation in the medioapical region of cells to control apical constriction during model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent manner during

X-linked form of Kallmann syndrome (KS), characterized by hypogonadotropic hypogonadism and anosmia, is due

Although this field has exploded during the past two decades, it is only recently that highly β-arrestin

During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog accumulation and myosin activation in the medioapical region of cells to control apical constriction during model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent manner during

Here, we report that the Ovarian Cancer G-Protein Coupled Receptor1 (OGR1 or GPR68) has dual roles in

paralleled with GPCR/β-arrestin-2 signals, indicating diminished levels of GPCR/signal adaptor complexes during

Due to increasing numbers of people with excess body weight, the MC4R has become a target of interest

During this sliding, bosentan passes the gate of the binding pocket from outside to inside of the pocket

Structural analysis of SMO domains shows significant changes in the CRD and ICD, during the course of

A major rearrangement of the HR seems implausible due to the tight arrangement and fixation by disulfide

The details of this dual contrasting functional feature of CBD, that is, displaying antagonistic and

Thus, increased SHH activity due to ciliary dysfunction may be required for the development of pathoetiological

striatum, demonstrating that the balance between TrkB and 5-HT2A may shift in certain brain regions during 5-HT2A and TrkB is a molecular mechanism for the brain-region-specific modulation of TrkB functions during

on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy "Pancreatic ductal PDAC) remains an aggressive disease that is expected to become the second cause of cancer fatalities during

During years, several studies have depicted the pivotal role of the cytoskeleton and lipid microdomains in controlling signalling compartmentalization during T cell activation and functions.

most densely innervated tissue of the body and possesses both immune and vascular privilege, in part due regarding the details of neuropeptide signaling and how it contributes to pathophysiology, which is likely due

review will cover specific roles of C3aR in driving cell type–specific and tissue specific responses during

endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes during

unique and complex process of ligand dissociation from the receptor and shed light on the distinct durations

She has played an active role during the COVID-19 pandemic as the UKRI’s COVID Response Director, and

Although specific details of the collaboration are yet to be released, EraCal has confirmed that the duo