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127 items found for "Single-cell transcriptome"
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Mechanistically, RGS16 restrained JNK/P38-mediated apoptosis in CRC cells through disrupting the recruitment , Fuao Cao Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation
Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration zebrafish Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
Through comprehensive transcriptomic analysis of IM-sensitive and IM-resistant CML groups, we identified , leukemia Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 13 with Dr. Amynah Pradhan
Amynah did her undergrad research measuring IP3 in airway smooth muscle cells and completed a Ph.D. at
- Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
tissue-damage-associated inflammation that epigenetically recruits, activates and orchestrates stem cells , Mutation Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
Such mutations may affect serotonin-mediated signaling in tumor cells as well as treatment strategies serotonin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma
Predicted rescue therapies were assessed in cell systems and mouse injury-dependent pneumonia models. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
Nitric acid (NO) inhibition was tested on the macrophage cell line RAW264.7. Prostatitis Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 103 with Dr Kathleen Caron
Eldridge Distinguished Professor and Chair of the Department of Cell Biology & Physiology at The University
- GPCR Retreat | Dr. GPCR Ecosystem
Sponsors GPCR Retreat The GPCR Retreat focuses on advances in our understanding of how GPCRs operate in cell
- Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology
author, presenter) Kohlenbach LM -2 Zhou Y -1 Marugan JJ -3 Barak LS -1 (senior author) 1-Department of Cell
- Ep 145 with Dr John Janetzko
My postdoc work has made use of several techniques including various mass spectrometry approaches, single particle cryo-EM and single-molecule fluorescence spectroscopy. Yamina sought clarification on John's involvement with GPCRs, but the transcript ended before he could
- Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Advance 2021, PNAS 2023, Nature Metabolism 2023), recognition of amine containing hormones by GPCRs (Cell
- Ep 71 with Dr. Jean Martin Beaulieu
The Beaulieu group is presently investigating how cell surface express proteins can act as allosteric
- Session III | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Upon NTF dissociation, an intracellular transcription factor (reporter module) is released, generating It was then adapted for the human aGPCRs CD97/ADGRE5 and Latrophilin/ADGRL3 and tested in HEK293T cells
- Ep 125 with Dr. Gregory Tall
Mechanical dissociation of the two fragments aided by protein binding ligands and cell movement serves
- Interrogating Multiscale Receptors Functions in Space
The Beaulieu group is presently investigating how cell surface express proteins can act as allosteric
- GPCR Retreat Logo Contest | Dr. GPCR Ecosystem
This contest is a unique opportunity to visually encapsulate the importance and impact of GPCRs in a single The winning logo designer will receive well-deserved recognition and a cash prize of $250.
- Ep 152 with Dr Arthur Christopoulos
long-term support from international and national competitive, charitable and commercial sources, as well Christopoulos has over 360 publications, including in leading international journals such as Nature,Science and Cell He also discussed the evolution of the field, from biochemical radioligand binding assays to cell-based a disease-specific approach, considering the clinical context and dialing in the desired effect, as well product profile (TPP) in drug development, with Arthur explaining its application in other contexts as well
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
organization-especially, the role of cilia-generated effectors in mediating diverse morpho-phenotypic outcomes-is not well In the hedgehog pathway, bifunctional GLI transcription factors generate both GLI-activators (GLI-A) Mukhopadhyay Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Session IV | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
My expertise includes biochemical approaches, proteomics and transcriptomics to name a few.
- Session I | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins which, four papers were published in Nature (2022a, 2022b, 2021, 2020); one paper was published in Cell
- Deciphering the genetic landscape of lumpy skin disease: Unraveling variable virulence through comprehensive genome sequence analysis in India
Authors R Mishra, S K Biswas, S Nandi, S Mahajan, K G Sai Balaji, V Gairola, D Poloju, S Gulzar, K P Singh , R K Singh, G K Sharma Tags Genome sequence , Lumpy skin disease , Molecular diversity , Virulence Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
Experiments were then conducted using these cells which were divided into four groups of negative control
- Ep 148 with Dr Arthur Christopoulos
long-term support from international and national competitive, charitable and commercial sources, as well Christopoulos has over 360 publications, including in leading international journals such as Nature,Science and Cell global challenges of healthcare workforce growth, climate change, and emerging psychiatric disorders, as well Between Two Ferns', the importance of maintaining team culture, and the potential health issues among well-known global challenges of healthcare workforce growth, climate change, and emerging psychiatric disorders, as well
- Ep 27 with Dr. Robert J. Lefkowitz
Well, it’s the one and only Robert J. Before we pressed record, I asked if I could call him Bob, and he answered that only his mom used to call him Robert, especially when she was upset with him. I very much enjoyed chatting with Bob, and I hope you’ll enjoy learning more about him as well. Dr.
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