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December 2021 "Geneva, Switzerland, December 17, 2021 – Addex Therapeutics Ltd (SIX: ADXN and Nasdaq:

July 2022 "Ad Hoc Announcement Pursuant to Art. 53 LR Geneva, Switzerland, July 22, 2022 – Addex Therapeutics

June 2022 "G protein-coupled receptors (GPCRs) represent a major therapeutic target class as they play In 2019, 5 out of 20 first-in-class approved therapeutic agents targeted GPCRs.

Modulator Research Collaboration for Substance Use Disorders "Geneva, Switzerland, August 15, 2022 - Addex Therapeutics

Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders with Tim Dyer Addex Therapeutics "Tim Dyer is the Co-Founder and CEO of Addex Therapeutics, which is focusing on the pharmacology known

Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised, therapeutic

Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealized, therapeutic

Phase 1 studies in Japan with JNJ-40411813 (ADX71149) "Geneva, Switzerland, November 15, 2021 – Addex Therapeutics

Screening Platform Ad Hoc Announcement Pursuant to Art. 53 LR Geneva, Switzerland, April 6, 2022 - Addex Therapeutics

Orchestrate the Interface between Health and Disease GPCRs arguably represent the most effective current therapeutic Given the tremendous success of GPCRs as therapeutic targets, considerable focus has been placed on the ability of these therapeutics to modulate diseases by acting at cell surface receptors.

Homology modeling relies on using the known structure of a homologous protein as a template to model The introduction of AlphaFold2 marked a major advancement in the field of GPCR structure prediction. to known structures. crucial for understanding how drugs can selectively target different receptor conformations to achieve therapeutic Ligand discovery from a dopamine D3 receptor homology model and crystal structure.

insights into the 5-HT2C receptor as a therapeutic target for substance use disorders Leigh Walker IPO to $331m Nxera Pharma and Antiverse Enter Collaboration To Design Novel GPCR- Targeted Antibody Therapeutics Using Generative AI Zombie Fungi Hijack Hosts’ Brains GPCR Therapeutics, Inc. has received Orphan Drug 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic insights into the 5-HT2C receptor as a therapeutic target for substance use disorders Targeting muscarinic

November 7th : Drug Disposition in Physiological Tissues as a Therapeutic Variable. December 5th : Unique Exploitable GPCR-Ligand Behaviors for Therapeutic Benefit. Generate:Biomedicines Announces Multi-Target Collaboration with Novartis to Discover and Develop Protein Therapeutics with SEP-786, a Novel Oral Small Molecule PTH1R Agonist for the Treatment of Hypoparathyroidism Confo Therapeutics an Antibody-based Agonist and a Class A GPCR Regulating Hunger and Satiety OMass Therapeutics Expands

pose significant challenges to traditional structural analysis methods. and remarkable scalability, providing crucial structural insights for drug development. challenges is crucial to fully harness AI's potential in accelerating drug discovery and optimizing therapeutic AlphaFold2 structures guide prospective ligand discovery. Accurate structure prediction of biomolecular interactions with AlphaFold 3.

Our partner, Domain Therapeutics, will attend the SACHS 23rd annual biotech event in Europe. Dr. Christopher Langmead and colleagues' work on the 5-HT2C receptor as a therapeutic target for substance GPCR Symposium on ''GPCRs as Therapeutic Modalities' Share your project with a 1-minute abstract video into the 5-HT2C receptor as a therapeutic target for substance use disorders Industry News Crinetics teams up with addiction treatment maker Indivior to make digital therapeutics for substance use disorders

April is the month of DNA Day, a special day commemorating the discovery of the DNA double helix structure GPCR-targeted drugs, and the exploration of GPCRs as key regulators of physiological processes and therapeutic microscopy, have allowed us to understand the structural dynamics during receptor activation. drug discovery and design targeting GPCRs, leading to the development of novel therapeutics. Structural bioinformatics analysis of variants on GPCR function.

GPCR Partner, Domain Therapeutics, for their nomination of the best-in-class CCR8 antibody candidate, History and function of the lactate receptor GPR81/HCAR1 in the brain: a putative therapeutic target G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics. Structural and Molecular Insights into GPCR Function Identification of a potential structure-based GPCR Domain Therapeutics announces nomination of best-in-class CCR8 antibody candidate, DT-7012, further strengthening

the development of more selective drugs capable of modulating specific signaling pathways, improving therapeutic This allows for tailoring the half-life of nanobodies to increase their therapeutic window depending its conformation, protects the Schiff base, and prevents protein degradation, potentially offering therapeutic Nanobodies: A Review of Generation, Diagnostics and Therapeutics. Structural biology.

These receptors respond to a variety of signals by undergoing structural changes that activate internal Twenty transition structures generated from overlapping particle subsets along this pathway provide a From the initial GTP binding, the structures highlight critical shifts in the α5 helix and the α-helical Concurrently, the α1 helix extends, propagating structural changes throughout the G protein. puzzles and underscores the importance of understanding cellular processes at the molecular level for therapeutic

GPCR Symposium on Structural and Molecular Insights on GPCR Activation! GPCRs in Cardiology, Endocrinology, and Taste Clinical, Pathophysiologic, Genetic, and Therapeutic Progress Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase. Secures $150 Million in Series B Financing to Advance Pipeline of Novel GPCR-targeted Medicines OMass Therapeutics Directors Crinetics Pharmaceuticals Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) Confo Therapeutics

November 7th: Drug Disposition in Physiological Tissues as a Therapeutic Variable. December 5th: Unique Exploitable GPCR-Ligand Behaviors for Therapeutic Benefit. dive into the   Classified GPCR News from October 14th to 20th, 2024 Industry News Ghent based Confo Therapeutics 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids Noval insights and therapeutic

appreciate the incredible versatility of GPCRs and how small molecules can affect their behavior for therapeutic Learn how to therapeutically exploit GPCRs (Physiology’s ‘Swiss Army Knife’) vast repertoire of ways Adjust ligand kinetics and tissue disposition for optimal therapeutic activity. and Molecular Insights into GPCR Function Structural insights into KSHV-GPCR constitutive activation Structural basis of μ-opioid receptor targeting by a nanobody antagonist Probing the energy landscape

Graeme Milligan and their colleagues research on Pro-phagocytic function and structural basis of GPR84 Kevin Wright on his new position as Director of Targeted and Immuno-oncology at GPCR Therapeutics, our GPCR Symposium on 'GPCRs as Therapeutic Modalities' with Richa Tyagi, Dr. Terry Kenakin, Dr. Kevin Wright Joins GPCR Therapeutics as Director of Targeted and Immuno-oncology Sosei Heptares Adds Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

Adhesion GPCRs A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets and Molecular Insights into GPCR Function Structural basis for recognition of 26RFa by the pyroglutamylated Industry News NanoImaging Services and Cube Biotech Collaborate to Enhance Cryo-EM Enabled Gene to Structure Workflow Domain Therapeutics Strengthens Its Intellectual Property for Its Series of Treg Depleting ACTH-Dependent Cushing’s Syndrome (ADCS) Septerna Presents Preclinical Data at ENDO 2024 Highlighting Therapeutic

GPCR Symposium on 'GPCRs as Therapeutic Modalities' Showcase your project with a 1-minute abstract video Bolsters Leadership Team as the Company Advances its Multi-Product Pipeline Toward Clinical Studies Confo Therapeutics 21st Annual Global Healthcare Conference CEO Raymond Stevens to Speak at STAT Future Summit on Obesity Therapeutics Function and Biased Signaling" at the DOT NEW October 3, 2023 | FREE Seminar: Changing paradigm on Therapeutics and Exhibition June 2 - 4, 2024 | Chemotactic Cytokines GPCR Jobs Researcher / Senior Researcher in Structural

GPCR Partner, GPCR Therapeutics, for passing the Technology Evaluation process for listing on the KOSDAQ GPCR Symposium on Structural and Molecular Insights on GPCR Activation. Structural and Molecular Insights into GPCR Function Structure-Activity Relationship Study of the High-Affinity GPCR Therapeutics passes the Technology Evaluation process for listing on KOSDAQ. function" (June 28 - 30, 2023) FREE Seminar Antibodies targeting Membrane Proteins - From Antigen to New Therapeutics

Bryan Roth and Brian Krumm for their study on Molecular glues as potential GPCR therapeutics Drs. breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects GPR56: A potential therapeutic Dynamics Structural insights into ligand recognition and activation of the succinate receptor SUCNR1 via site-selective activation of mTOR GPCR Binders, Drugs, and more Molecular glues as potential GPCR therapeutics and Molecular Insights into GPCR Function Structural basis for hormone recognition and distinctive Gq

GPCRs in Oncology and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists Reviews, GPCRs, and more The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets. Structural and Molecular Insights into GPCR Function Structural basis of selective cannabinoid CB2 receptor It Will Participate For H1 2023 Learn more about Exscientia new pipeline candidate, EXS74539 Domain Therapeutics women-men professional equality index Octant introduces Hypatia, their New Robotic Drug Hunter GPCR Therapeutics