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281 items found for "Structure Therapeutics"
- TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
These findings have implications for therapeutically targeting TIPE proteins in human inflammatory and GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
mediator in the advancement of OSCC, offering a potential avenue for the development of innovative therapeutic GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways
pancreatic adenocarcinoma (PDAC) continues to present a formidable clinical challenge, demanding innovative therapeutic GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
Pharmacological inhibition of the lipid synthesis pathway by statins is a therapeutic approach to control GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Identification of Small-Molecule Antagonists Targeting the Growth Hormone Releasing Hormone Receptor (GHRHR)
We therefore report the first nonpeptide antagonists of GHRHR and propose a structural basis for inhibition GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure in mice
GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer
Therefore, our findings demonstrated that GPR37 may represent a viable therapeutic target for NSCLC." GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor
controlling the functions of monocytes and dendritic cells and that targeting GPR141 may be a possible therapeutic GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Characterization, expressional and evolutionary analysis of five fish-specific CCRs (CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b) in largemouth bass (Micropterus salmoides)
The correction of nomenclatures of these CCRs were confirmed by phylogenetic analysis, structural analysis GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10
It is expected that the biological responses of two structurally similar peptides should be coordinated GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Ep 23 with Dr. Qing Fan
Qing is a structural biologist interested in the molecular mechanisms controlling how class C GPCRs transmit
- RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway
inhibition of the PKA-Hippo signaling pathway Published date March 2, 2024 Abstract " Background: Novel therapeutic GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Interplay between G protein-coupled receptors and nanotechnology
understanding of the designated value of GPCRs for molecular engineering of biomaterials with GPCRs in therapeutical GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer
In the past, studies predicting therapeutic drug targets for cancer therapy focused on the assumption GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Neutrophils are itching to specialize
GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- The landscape of cancer-rewired GPCR signaling axes
GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus
GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells
GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- GPR56: GPCR as a guardian against ferroptosis
GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells
GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Ep 12 with Dr. Antonella Di Pizio
Italy, followed by a Ph.D. in computational medicinal chemistry, during which she developed a taste for structural
- LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration
Moreover, our findings propose a therapeutic potential in combined CXCR4 and LPA1 inhibitors for cancer GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Session VIII | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
of this work centered on elucidating novel mechanisms by which β-adrenergic receptors impact cardiac structure GPCRs in the regulation of physiologic/pathologic function in the heart in an effort to uncover novel therapeutic
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
Molecular docking was conducted on GPR35-active compounds and GPR35 crystal structure. GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural
- Ep 99 with Yamina Berchihce
She developed expertise over the past two decades studying structure/function relationships of GPCRs
- Ep 123 with Dr. Lukas Grätz
branched out to multiple areas of GPCR research such as sequence alignments, generic numbering systems, structure
- Ep 138 with Dr. Daniel Isom
biophysicist, systems and synthetic biologist, technologist, heavy CRISPR user, protein sequence- and structure-based
- Ep 124 with Gáspár Pándy-Szekeres
branched out to multiple areas of GPCR research such as sequence alignments, generic numbering systems, structure
