Ecosystem
Beta Site
Search Results
151 items found for "Systemic treatment"
- Ep 107 with Dr. Roger Sunahara
Our goal is to develop safer beta2AR-selective ligands for the treatment of asthma and acute rescue therapy The laboratory continues to engineer the enzyme to optimize its potential as a treatment for cocaine
- Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy
and targeted therapy through therapeutic targeting of olfactory receptors as an adjunct anticancer treatment
- Ep 154 with Dr Badr Sokrat
Christian Baron studying bacterial secretion systems, I joined the molecular pharmacology laboratory Philip Woozab’s, focusing on bacterial secretion systems, GPCRs, and bioinformatics. Yamina advised him to consider career options after his postdoc and adapt to different systems.
- Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes
November 1, 2022 Abstract Type 2 diabetes (T2DM) is characterized by insulin secretion deficiencies and systemic
- G protein-coupled receptors related to autoimmunity in postural orthostatic tachycardia syndrome
Herein, we review the association of anti-GPCR autoantibodies with disorders of the autonomic nervous system
- Ep 45 with Dr Ralf Jockers
variants are biased and their defects are signaling pathway-specific opening new perspectives for T2D treatment
- GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis
Diagnostic indicators and treatment objectives for CRC are urgently needed.
- Ep 92 with Dr. Stephane Angers
led to the development of novel antibody molecules blocking and activating the Wnt pathway for the treatment
- The landscape of cancer-rewired GPCR signaling axes
date May 8, 2024 Abstract "We explored the dysregulation of G-protein-coupled receptor (GPCR) ligand systems
- Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling
in neurodegeneration and the characterization of neuroprotective drugs acting on the glutamatergic system
- The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer
unconventional Class C GPCR but also hold the potential to advance drug development targeting GPRC5D for the treatment
- Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus
This may help to develop more potent ligands for the treatment of inflammatory related diseases."
- GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer
Genetic mouse models of CRC coupled with Gpr176-deficiency are investigated, and in vivo and in vitro treatments
- Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans
Nevertheless, only exposure to 10 μg/L CPPDQ induced neurodegeneration in GABAergic system.
- From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction
In some model systems, CCN1 and CCN2 play key roles in LPA/S1P-induced cell migration and proliferation
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
proinflammatory glycoproteins liberated by the activation of the biochemical cascade of the complement system
- Biochemical pharmacology of adenylyl cyclases in cancer
therapeutic strategies for personalized oncology and might enhance the efficacy of chemoimmunotherapy in the treatment
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
27, 2023 Abstract "Somatostatin receptors are clinically validated GPCR biomarkers for diagnosis and treatment
- Atypical Structure and Function of Typical Chemokine Receptors
of biochemical and behavioural approaches to understand the many roles of NMDA receptors and to find treatments
- Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
Mechanistic studies revealed that 8GL treatment inhibits the activation of the mammalian target of rapamycin
- Principles of Pharmacology in Drug Discovery II
powerful applications of new cellular assays to determine GPCR ligand behavior in different functional systems
- Principles of Pharmacology in Drug Discovery II
powerful applications of new cellular assays to determine GPCR ligand behavior in different functional systems
- Trainee Symposium I
studies, Emile is interested in characterizing novel G protein-coupled receptors (GPCRs) ligands for the treatment
- The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication
the effect of EBI2 antagonists on the residual viral production persisting in patients aviremic under treatment
- Ep 113 with Dr. Prasenjit Saha
receptors and serve as targets for more than one-third of all prescribed drugs currently used in the treatment
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
2023 Abstract "Immune checkpoint blockade (ICB) targeting PD-1 and CTLA-4 has revolutionized cancer treatment
- Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer
Taken together, current data are prompting the hypothesis of a prophylactic treatment option with stable
- Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy
complexities of extracellular ATP (e-ATP) and ADO effects on the TME poses challenges in identifying optimal treatment
