2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated migration of B cells recruits a specific GRK to chemoattractant receptors and plays an important role in the control of B cell Authors Taiichiro Shirai , Akiko Nakai , Kazuhiro Suzuki Tags B cell migration , COMMD3/8 complex , GRK Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

cancer therapy Published date September 12, 2024 Abstract "G protein-coupled receptors (GPCRs) are vital cell highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity, cancer cell Treatment Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Whereas it is well established that single-cell migration is often guided by gradients of chemokines Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and patterns to the size and geometry of the environment, and provide a guidance cue for other comigrating cells dual role of CCR7 as a GPCR that both senses and consumes its ligand can thus provide a novel mode of cellular Michael Sixt Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

human protein atlas database, we inferred the most predominant GPCR-mediated microbial metabolite-human cell permeability of the small-molecules we elucidated their molecular interactions with specific human cell receptors, particularly expressed on human intestinal epithelial cells, immune cells and the nervous Metabolites Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Individual cells trend to adapt environmental changes in a "whole" flora through communications, allowing Furthermore, GprC and AcyA regulate the primary metabolism as well as secondary metabolism, and further These studies highlight a crucial G protein signaling pathway for cell communication that is mediated ochraceus, hoping to achieve comprehensive prevention and control of mycotoxin pollution from interrupting cell Authors Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication

post-translational modification that supports membrane interactions of proteins involved in various cellular We examined the prenylation of carboxy-terminus (Ct) mutated Gγ in cells exposed to Fluvastatin and prenyl monitored the subcellular localization of fluorescently tagged Gγ subunits and their mutants using live-cell Given the cell and tissue-specific expression of different Gγ subtypes, our findings indicate a plausible mechanism allowing for statins to differentially perturb heterotrimeric G protein signaling in cells

heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell disrupted their engagement with GIV/Girdin, thereby blocking noncanonical G-protein signaling in tumor cells and inhibiting proinvasive traits of metastatic cancer cells. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Here, we showed that US28 increased the malignancy of U251 glioblastoma cells by enhancing signaling Enhanced S1P signaling promoted glioblastoma cell proliferation and survival by activating the kinases US28 also activated the S1P signaling axis in HCMV-infected cells. Authors Nick D Bergkamp , Jeffrey R van Senten , Hendrik J Brink , Maarten P Bebelman , Jelle van den Martine J Smit Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune cell Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Immunology Itaconate in host inflammation and defense Published date March 5, 2024 Abstract "Immune cells Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory itaconate Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

elevated in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell studies in mice, we show that GPR143 promotes metastasis by secreting exosomes and increasing cancer cell provide a mechanism for regulating the exosomal proteome and demonstrate its ability to promote cancer cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Docking of identified hits to RGS2 as well as other RGS structures was used to screen the hits for potent Whole cell assays showed the top 10 ranking compounds, AJ-1-AJ-10, to inhibit RGS2-Gαq interactions. All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays. In addition, AJ-3 inhibited the migration of LNCaP prostate cancer cells in wound healing assays. M Mahfouz Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Furthermore, fibroblasts abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages in the fibrotic lung. GPR176 expression was unaffected by TGFβ1 stimulation in rat renal fibroblast NRK-49 cells, whereas knockdown of Gpr176 by siRNA reduced TGFβ1-induced expression of αSMA, fibronectin, and collagen as well as Smad2 GPCR , TGFβ1 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

treating patients suffering from lung cancer is to target surface receptors overexpressed on tumor cells cancers, such as prostate and ovarian cancer, facilitating the invasive and metastatic capacity of tumor cells The expression levels of KLKs in this neoplasm are modulated by the secretome of the different cell types SARS-CoV-2 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

PAXIP1-AS1) was found to promote proliferation, migration, EMT, and apoptosis of ovarian cancer (OC) cells in OC cell lines, but the relationship between PAXIP1-AS1 expression and clinical characteristics, prognosis QRT-PCR was used to validate the expression of PAXIP1-AS1 in OC cell lines. PAXIP1-AS1 was significantly downregulated in OC cell lines compared with IOSE29 cell line. , Hui Liu Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

In response to a chemoattractant stimulation, cells lacking PLCγ2 (plcg2kd) displayed altered dynamics phosphorylation and cofilin activation; impaired dynamics of actin polymerization; and consequently, defects in cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Promotes Osteogenic Differentiation Published date May 30, 2023 Abstract "Objectives: Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cell possessing self-renewal and multilineage differentiation Materials and methods: The viability and apoptosis of human DPSCs (hDPSCs) were determined using Cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis and PKC via the signaling pathway of miR-19a/GRK6/GPR39/PKC, which accordingly resulted in suppressed cell apoptosis and promoted cell migration and invasion. scRNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

G protein-coupled receptors (GPCRs) are involved in endocrine and metabolic processes as well as many increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation in 3T3-L1 cells Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Replication by Regulating Ca2+ Flux Published date May 29, 2023 Abstract "Chemokine production by epithelial cells coronavirus porcine epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Laboratories cell-porcine kidney 1 epithelial cells (LLC-PK1). Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Christopher Langmead on the web Monash University T witter Google Scholar Linkedin PubMed Monash Neuromedicines

research interests lies in the elucidation of signal transduction pathways in cancer, immune and bone cells area of interest has been the elucidation of the molecular basis for a rare autosomal human disease called The Rottapel lab has shown that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell

Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used , RNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Read More September 25, 2024 The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell GPR56) promotes pressure overload-induced heart failure Read More Articles from Ecosystem Contributors Call receptors CXCR4 and ACKR3 by receptor activity-modifying proteins Read More December 13, 2024 Single-cell

controlling their steady state trafficking and sometimes their agonist-induced internalisation, as well Norbin in the trafficking of endogenous C5aR1 and CXCR4 in primary neutrophils by flow cytometry and cell β-arrestin-dependent mechanism and limits the recycling of internalised C5aR1 and CXCR4 back to the cell C5a-stimulated membrane translocation of Tiam1, Vav, and PKCδ, and activation of Erk and p38 Mapk pathways, as well β-arrestin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

., PNAS, 2014) in breast cancer pathogenesis, using mouse models, three-dimensional cell culture and Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its He also discussed the impact of disrupting histone processing on rapidly proliferating cells, such as cancer cells, and suggested a therapeutic index for a drug called JTE-6.7. He also discussed his experiments and discoveries about GPR161 in mammary epithelial cells, the effect

G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated The levels of GPCRRGs were examined in normal and OV cell lines using quantitative reverse-Etranscription epithelial Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs Tags Breast cancer , Regulator of G protein signaling 5 , Vascular remodeling , Vascular smooth muscle cells Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR