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195 items found for "Tumor-associated macrophages"
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
data of protein sequences and molecular fingerprints coming from databases such as the GPCR-Ligand Association prediction and clinical responses: AI can predict potential off-target effects and adverse drug reactions associated However, there are also certain cons associated with the use of AI in this field: 1) the quality and Towards a comprehensive understanding of GPCRs, ligands, diseases, and their associations: open-access databases from experimental labs and new AI techniques will allow more associations and will promote
- 📰 GPCR Weekly News, July 10 to 16, 2023
ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated Technologies NEW Computational Protein Design (GPCR) Postdoctoral Fellow, Caron Lab Clinical Trial Associate
- 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024
neuroprotective and neurogenic properties GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral position Senior or Lead Researcher Senior Scientist, Cryo-Electron Microscopy Postdoctoral Research Associate
- Applying Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders with ...
treating central nervous system and neurologic disorders, particularly movement disorders like dyskinesia associated
- 📰 GPCR Weekly News, May 15 to 21, 2023
2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs NEW Postdoctoral Research Associate NEW Lab Manager Vice President, Medical Affairs Associate Scientist - Technology Senior Research Scientist
- 📰 GPCR Weekly News, August 7 to 13, 2023
Proteins (March 24 - 29, 2024) GPCR Jobs NEW Postdoctoral Fellow NEW Research Laboratory Specialist Associate NEW Postdoc Research Associate Director, Regulatory Affairs Research Scientist/Senior Scientist I -
- 📰 GPCR Weekly News, March 25 to March 31, 2024
congrats to: Junyi Liang, Niña Caculitan, and Adam W Smith for their research on β2-adrenergic receptor associates channel signaling and pain homeostasis GPCRs in Oncology and Immunology The β2-adrenergic receptor associates 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Postdoctoral Associate
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell...
Adrenergic Receptor (β2-AR) is significantly overexpressed in various types of malignancies, which is associated
- Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
herpesvirus 6 and 7 with two receptors: U12 and U51; Epstein-Barr virus with one: BILF1; and Kaposi's sarcoma-associated
- Adenosine receptor signalling in Alzheimer's disease
the disease, the current mainstay of treatment cannot modify pathogenesis or effectively address the associated
- Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals
modulation of fundamental physiological functions, and dysregulation of dopaminergic transmission is associated
- Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex
reveals an atypical position of β-arrestin1 compared to previously described GPCR-arrestin assemblies, associated
- Adenosine receptor signalling in Alzheimer's disease
the disease, the current mainstay of treatment cannot modify pathogenesis or effectively address the associated
- 📰 GPCR Weekly News, June 3 to June 9, 2024
vitro pharmacology Senior Scientist - Receptor Pharmacology Postdoctoral Scientist Senior Research Associate /Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell Biology/Biochemistry Post
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
Although blockade of GPR84 may potentially prove effective also in diseases associated with inflammation
- Domain Therapeutics and Explicyte enter partnership agreement in immuno-oncology
The two companies will combine their expertise to identify GPCR targets and associated biomarkers to
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
molecules, such as phosphoinositides, can bind to specific domains of β-arrestins, promoting their association obtained in this study proposes novel molecular mechanisms in which β-arrestin exhibits spontaneous pre-association This pre-association enables β-arrestin to explore its surroundings through lateral diffusion and engage
- The complicated lives of GPCRs in cardiac fibroblasts
We discuss how such events may be distinct depending on where the GPCRs and their associated signaling
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
inhibitors in clinical trials could be of a great importance to limit the inflammatory complications associated
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
inhibitors in clinical trials could be of a great importance to limit the inflammatory complications associated
- GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
August 2022 "Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated
- The regulation of PKA signaling in obesity and in the maintenance of metabolic health
identified in PKA subunit genes cause Cushing syndrome that is characterized by metabolic dysregulation associated
- Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs
Pain may associate with inflamed tissue characterized by acidic pH.
- RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany...
Recently, functional autoantibodies targeting GPCRs have been associated with various disease-specific
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
knockout cells and β-arrestins lacking the finger-loop-region, we show that the two isoforms prefer to associate
- Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
September 2022 "GPCR signaling and function depend on their associated proteins and subcellular locations
- Functional modulation of PTH1R activation and signaling by RAMP2
2022 "Receptor-activity-modifying proteins (RAMPs) are ubiquitously expressed membrane proteins that associate
- 📰 GPCR Weekly News, December 4 to 10, 2023
Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Fellow NEW Post-Doc Research Associate NEW Assistant/Associate Professor Principal scientist – oncology biomarker expert Postdoctoral Fellow