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353 items found for "Xiaoxia Li"

  • CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions

    Prenyltransferases tether isoprenoid lipids to proteins via a thioether linkage during prenylation. Pharmacological inhibition of the lipid synthesis pathway by statins is a therapeutic approach to control monitored the subcellular localization of fluorescently tagged Gγ subunits and their mutants using live-cell

  • Itaconate in host inflammation and defense

    Authors Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory

  • Chemoattractant receptor signaling in humoral immunity

    After ligand binding, GPCRs are phosphorylated by different GPCR kinases (GRKs) at distinct sites on

  • A journey from Duke to McGill along the dopamine circuit

    Brunos Giros on the web The Douglas Research Centre McGill University Pubmed Google Scholar LinkedIn

  • Ep 107 with Dr. Roger Sunahara

    GPCR Podcast << Back to podcast list Dr. Roger Sunahara About Dr. This is an important perspective in the pursuit of receptor subtype-specific ligands, a major aspect One example of our recent work surrounds a structure-based effort to develop ligands that specifically We have identified several GPCR ligands that allosterically modulate orthosteric ligand binding and target Roger Sunahara on the web UCSD Profile Google Scholar ResearchGate LinkedIn Dr.

  • Trainee Symposium I

    I Date & Time Thursday, November 2nd / 1:45 PM - 2:45 PM Title: Virion Display to Discover a Novel Ligand My project is investigating a new protein ligand for a GPCR and its potential role in obesity. GPCR Title: Characterization of Novel Opioid-Neurotensin Bifunctional Ligands Designed to Target Pain his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors (GPCRs) ligands Bassam Albraidy on the web X (Twitter) LinkedIn Dr.

  • Ep 120 with Brendan Wilkins

    GPCR Podcast << Back to podcast list Brendan Wilkins About Brendan Wilkins "Brendan completed his undergraduate This project aims to characterise the molecular pharmacology of GPR146 and to validate the proposed ligands of GPR146 in line with IUPHAR-NC guidelines on deorphanisation of orphan GPCRs. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • Ep 43 with Dr. Stuart Maudsley

    GPCR Podcast << Back to podcast list Dr. Stuart Maudsley About Dr. Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • Ep 54 with Dr. JoAnn Trejo

    GPCR Podcast << Back to podcast list Dr. JoAnn Trejo About Dr. JoAnn Trejo Dr. JoAnn Trejo on the web UC San Diego Trejo Lab Wikipedia ​​​​LinkedIn Google Scholar Orcid Twitter UC GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design

    Subsequently, we selected a compound from a library of backbone cyclic peptides generated toward the

  • GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

    in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell lines

  • Ep 112 with Julia Gardner

    GPCR Podcast << Back to podcast list Julia Gardner About Julia Gardner Julia is a senior undergraduate Julia Gardner on the web Rajagopal Lab Google Scholar ResearchGate LinkedIn Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • GPCR Retreat 2023 - Part I

    GPCR Podcast << Back to podcast list Irfan Dhanidina, Dr. Kathleen Caron and Dr. who translate important GPCR research into novel therapies for patients. " Irfan Dhanidina on the web LinkedIn These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • Ep 151 with Dr GPCR Board

    GPCR Podcast << Back to podcast list Dr. GPCR Board About Dr. Yamina Berchiche "Dr. Yamina A. Yamina Berchiche on the web Website LinkedIn Facebook Twitter ResearchGate PubMed Google Scholar Dr. Maria Waldhoer on the web LinkedIn T witter Pubmed Dr. GPCR About Dr. JoAnn Trejo "Dr. JoAnn Trejo on the web UC San Diego Trejo Lab Wikipedia ​​​​LinkedIn Google Scholar Orcid Twitter UC Anne Marie Quinn on the web Google Scholar The Org LinkedIn Twitter Dr.

  • Ep 70 with Dr. Stephen Ferguson

    GPCR Podcast << Back to podcast list Dr. Stephen Ferguson About Dr. Stephen Ferguson Dr. Stephen Ferguson on the web Carlton University Canada Research Chairs Twitter ResearchGate LinkedIn Dr GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • Ep 135 with Dr. Katarzyna Marcinkiewicz

    GPCR Podcast << Back to podcast list Dr. Katarzyna Marcinkiewicz About Dr. Katarzyna Marcinkiewicz on the web LinkedIn Nature The Spectator Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases

    Likely, many other metabolites will be present at high concentrations. helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently Western lifestyle Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein

  • Ep 30 with Dr. Elva Zhao

    GPCR Podcast << Back to podcast list Dr. In her spare time, Elva likes to run in the mountains, play with Tilly (a 9-year old retired greyhound Elva Zhao on the web LinkedIn Monash University Pubmed Twitter Dr. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure in mice

    dysfunction and immunotherapy failure in mice Published date July 15, 2023 No Abstract available No Authors listed

  • Ep 108 with Dr. Kenneth A. Jacobson

    GPCR Podcast << Back to podcast list Dr. Kenneth A. Jacobson About Dr. Kenneth A. Jacobson received his BA in Liberal Arts from Reed College in 1976 and his Ph.D. in Chemistry from the Jacobson on the web NIDDK Web of Science Google Scholar LinkedIn Twitter Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • Ep 55 with Mark Schmeizl

    GPCR Podcast << Back to podcast list Mark Schmeizl About Mark Schmeizl Mark leverages 30 years in various life science laboratories & commercial roles with his network of VC & PE contacts to help senior-level life science executives identify new opportunities. Mark Schmeizl on the web Website LinkedIn Dr. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

  • GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment

    Authors Judith Anthea Stolwijk , Susanne Wallner , Judith Heider , Bernadett Kurz , Lisa Pütz , Stefanie Michaelis , Barbara Goricnik , Julia Erl , Linda Frank , Mark Berneburg , Frank Haubner , Joachim Wegener

  • Ep 32 with Dr. Chris Tate

    GPCR Podcast << Back to podcast list Dr. Chris Tate About this episode Dr. determination of the β1-adrenoceptor and adenosine A2A receptor in multiple different conformations bound to ligands Chris Tate on the web LinkedIn ResearchGate Pubmed Google Scholar Sosei Heptares Wikipedia MRC Laboratory GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium

    assays were performed using PBMCs isolated from these individuals in response to the synthetic GPR15 ligand

  • Ep 156 with Dr. Justin English

    GPCR Podcast << Back to podcast list Empowering Drug Discovery for the GPCR Community with Dr. Justin English on the web The English Lab University of Utah Google Scholar LinkedIn Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • Ep 52 with Dr. Benjamin Myers

    GPCR Podcast << Back to podcast list Dr. Benjamin Myers About Dr. These studies have revealed new and unexpected ways for membrane lipids to regulate GPCR activity and operate within the primary cilium, a tiny antenna-shaped structure at the cell surface with critical links GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

  • Ep 152 with Dr Arthur Christopoulos

    GPCR Podcast << Back to podcast list A Brief History of allosteric modulation with Dr. Arthur Christopoulos on the web Monash University Wikipedia Google Scholar LinkedIn Dr. Arthur explained the concept of endogenous allosteric ligands and the possibility of using a neutral allosteric ligand as a preferred therapeutic approach, emphasizing the importance of looking for low Thanks for listening to this podcast episode This short survey will help us understand your needs to

  • The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis

    Brentuximab vedotin (BV), an anti-CD30 monoclonal antibody linked to a microtubule-disrupting agent, investigations in vitro and in vivo revealed that the levels of an anti-apoptotic protein, Bcl-2, and a rate-limiting

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