Jürgen Wess and Liu Liu for their study on A novel function of the M2 muscarinic receptor Drs. vivo via differential phosphorylation Increased transcriptional elongation and RNA stability of GPCR ligand -PH domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate dynamics in living

Suchismita Roy et al. have explored how growth factors can modulate canonical G protein signaling, shedding light They employed a series of phospho-mimicking mutants and assays such as linear ion trap mass spectrometry Key findings include: Phosphorylation Hotspots: P Loop (Ser44, Ser47, Thr48): Impairs ligand-stimulated Interdomain Cleft (Ser151, Tyr154, Tyr155): Phosphorylation at Tyr154 and Tyr155 impaired ligand-stimulated C Terminus (Tyr320): Phosphorylation at Tyr320 disrupted Gβγ binding, receptor coupling, and ligand-stimulated

Brendan Creemer, Thomas Gardella, and Ross Cheloha for their work on Highly biased agonism for GPCR ligands Badr Sokrat is live! You can now watch podcast episodes in video format on our website. GPCR Activation and Signaling Highly biased agonism for GPCR ligands via nanobody tethering Mechanistic orientation using a neurotensin receptor 1 peptide Illuminating the neuropeptide Y4 receptor and its ligand asthma GPCR Events, Meetings, and Webinars June 2 - 7, 2024 | Chemotactic Cytokines June 4, 2024 | Live

receptors (CKRs) that signal via Gαi and 4 official atypical chemokine receptors (ACKRs) which engage in ligand Indeed, ACKRs behave as scavenging “decoys” in order to either limit chemokines spatial availability sites, while maintaining the responsiveness of canonical G protein-coupled CKRs that bind to the same ligand inflammatory response when needed; and it may interfere with other chemokine receptors which share the ligands CKRs should be considered when evaluating the safety and therapeutic efficacy of blocking receptor-ligand

Jacek Mokrosiński is live! Development of Selective Cannabinoid Receptor 2 Inverse Agonists Development of Putative Bivalent Dicovalent Ligands prospects, and pathophysiological perspectives Structural and Molecular Insights into GPCR Function Bilayer lipids modulate ligand binding to atypical chemokine receptor 3 Industry News New cannabinoid CB1 receptor | ENDO 2024 NEW June 3 - 6, 2024 | BIO 2024 June 2 - 7, 2024 | Chemotactic Cytokines June 4, 2024 | Live

To my surprise and delight, the neurexins happened to be ligands for one isoform of the Latrophilins. AB: The next workshop will likely bring together some of the hottest adhesion GPCR research going on community, added to the fact that this will all take place for the first time in a developing country like The food: While in Mexico, eat like one. The diversity is humongous. What mariachi song are you most likely to shout along to at 3 AM?

Initially, the activation of small GTPases like RAS leads to the activation of the MAP kinase kinase

Azietaku for his first contributor article on Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light Lyu, Brian Shoichet, Bryan Roth, et al. for their research on AlphaFold2 structures guide prospective ligand Arthur Christopoulos is now live, titled "A Brief History of Allosteric Modulators."  of the Prototypic G Protein-Coupled Adenosine A2A Receptor AlphaFold2 structures guide prospective ligand SLAS Europe 2024 Conference and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines NEW June 4, 2024 | Live

This highlights the power of advanced imaging techniques like cryo-EM in solving complex biological puzzles

Alejandra Tomas, et al. for their study on Lipid regulation of the glucagon receptor family Drs. Please reply to this email if you'd like to sponsor this event. response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures Lipid glucagon receptor family Technologies for the discovery of G protein-coupled receptor-targeting biologics Lipid pathway networks as cancer therapeutic targets Generation of comprehensive GPCR-transducer-deficient cell lines

We got a little busy with all the major events at Dr.GPCR, so our weekly news looks slightly different

Hoare's workshop for individuals who live and work in developing countries.  mapping G-protein-coupled receptor agonists Development of a synthetic relaxin-3/INSL5 chimeric peptide ligand for NanoBiT complementation binding assays Generation of a deep mouse brain spectral library for transmembrane Structural and Molecular Insights into GPCR Function Fungal alkaloid malbrancheamide reorients the lipid

Hoare's workshop for individuals who live and work in developing countries.  protein signalling and modulates excitability of human induced pluripotent stem cell-derived nociceptive-like Methods & Updates in GPCR Research Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-cell United With or Without an Additional Transmembrane Sequence Indicate Classification into Three Groups of Linkers

Valery V Fokin  et al. for their research on Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target Gunnar Schulte, Lukas Grätz, Pawel Kozielewicz, et al Hoare's workshop for individuals who live and work in developing countries. If you have any research you would like to showcase to our community, you can submit a poster presentation Enables Ligand Discovery for a Key GPCR Target GPCRs in Cardiology, Endocrinology, and Taste Orphan

Advances in structural genomics, coupled with techniques like X-ray crystallography and cryo-electron The genetic variation in GPCRs is extensive; databases like GPCRdb provide a large database of genetic

Hoare's workshop for individuals who live and work in developing countries. If you have any research you would like to showcase to our community, you can submit a poster presentation Classified GPCR News from April 1st to 7th, 2024 GPCR Activation and Signaling GPRASP1 loss-of-function links Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver

This week's highlight includes congrats to: Junyi Liang, Niña Caculitan, and Adam W Smith for their research The workshop includes: 4x 2 hours live Zoom sessions (45-50 minutes lecture + 1-hour Q&A) Thirty minutes Hoare's workshop for individuals who live and work in developing countries. receptor Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects on mouse metabolism Mechanistic insights into sodium ion-mediated ligand binding affinity and

3 Pathfndr-2 Study In Acromegaly Patients GPCR Events, Meetings, and Webinars March 24 - 29, 2024 | Ligand

in brain intercellular signaling Are there sex differences in oxytocin and vasopressin V1a receptors ligand that is now part of Bristol Myers Squibb GPCR Events, Meetings, and Webinars March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

We are pleased to confirm the participation of a great lineup of speakers, namely Drs.  2024 GPCR Activation and Signaling Glu1022.53-Mediated Early Conformational Changes in the Process of Light-Induced Webinars March 13 - 15 | Biologics 2024 March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Sandra Berndt, Ines Liebscher, and Susanne Horn et. al for their for their research on adhesion GPCR Hoare, you’ll learn how to analyze your data like a pro. Stay tuned for more information. Dr. receptors: from radioligand binding to cellular signaling GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism State-dependent dynamics of extramembrane domains in the β2 -adrenergic receptor Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

For example, the lipid composition of intracellular membranes may influence GPCR dynamics and signaling outcomes, changing the receptor conformation and accessibility to ligands2. signaling, GPCRs are also known to localize to the Golgi apparatus, where they can be activated by ligands receptor 5 (mGluR5), can lead to sustained calcium signaling and activation of transcription factors like This may involve the development of specialized delivery vehicles, such as nanoparticles or liposomes

Patrick Sexton, and Matthew Belousoff et al. for their work on Lipid-Dependent Activation of the Orphan We would like to extend our heartfelt thanks to Dr. We will be offering this live course again later this year. You'll share your contributor articles with the community, stay updated with GPCR literature, join a determines temperature acclimatization of Caenorhabditis elegan Species-Specific Duplicated FMRFaR-like

You can still join this waitlist and be the first to know when the live course is offered later this You'll share your contributor articles with the community, stay updated with GPCR literature, join a Drugs, and more Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand to specialize A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Magdalena M Scharf, Antonella Di Pizio, Ines Liebscher, Hannes Schihada, and Gunnar Schulte et al. on We will be offering this live course later this year. You'll share your contributor articles with the community, stay updated with GPCR literature, network GPCRs in Cardiology, Endocrinology, and Taste G protein-coupled receptors driven intestinal glucagon-like Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

We are considering rerunning this live course later this year. You'll share your contributor articles with the community, stay updated with GPCR literature, join a signaling mediated by β-arrestins and its potential role in heart failure GPCRs in Neuroscience Role of lipids in Pharmacology and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Take 2 minutes to fill out this survey and let us know what you liked, what you didn’t, and what we can analysis of Gi-coupling receptors via engineered Gt and Nb35 application Imaging GPCR Dimerization in Living in Pharmacology and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

If you'd like to join colleagues and Dr. The cost is USD $299 and includes: Four live Zoom sessions (1 hour lecture + 30 mins Q&A each) A 30-minute News Novartis Lutathera® significantly reduced risk of disease progression or death by 72% as first-line 2024 | 2024 BPS Annual Meeting NEW March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating