Search Results
140 items found for "Yanbin Ke"
- Effect Delta-9-tetrahydrocannabinol and cannabidiol on milk proteins and lipid levels in HC11 cells
antagonist with THC, and a CB2 agonist with CBD, reversed the impact of THC and CBD on the mRNA levels of key
- Co-activation of GPCRs facilitate GIRK-dependent current
KEY POINTS: Inhibitory D2 and GABAB receptors modulate dopamine neuron activity through shared G protein-coupled
- Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
Cholesterol is a key constituent of higher eukaryotic membranes and is believed to contribute to the
- The regulation of PKA signaling in obesity and in the maintenance of metabolic health
Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic
- Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone...
One key underlying mechanism behind this surgery is the cooperative improved action of the preproglucagon-derived
- The complicated lives of GPCRs in cardiac fibroblasts
will focus on the relatively less well-studied effects of GPCRs in cardiac fibroblasts, focusing on key
- The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
We confirmed the interaction of VLGR1 with key proteins of MAMs by pull-down assays in vitro complemented components in MAMs and point to an essential role of VLGR1 in the regulation of Ca2+ homeostasis, one of the key
- Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...
KEGG pathway analysis highlighted the most significant pathways associated with depression treatment, showed that Polygalaxanthone III, Girinimbine and Pachymic acid performed greater binding ability with key In conclusion, this study preliminarily revealed key active components in KXS, including Gomisin B, Asarone
- Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist...
Using site-directed mutagenesis and species-swapping approaches, we identified key conserved amino acids
- Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
October 2022 "Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
receptors primarily induce the chemotaxis of leukocytes, especially neutrophils, during inflammation, a key
- High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...
distribution of the GPCR smoothened "The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key
- Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex
Arrestins interact with G protein-coupled receptors (GPCRs) to stop G protein activation and to initiate key
- Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging...
receptor (CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing a key
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
receptors primarily induce the chemotaxis of leukocytes, especially neutrophils, during inflammation, a key
- GRK2 in cardiovascular disease and its potential as a therapeutic target
Thus, identifying novel molecular targets for developing HF therapeutics remains a key research focus
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
The second messenger cyclic adenosine monophosphate (cAMP) is a key mediator in many GPCR signaling pathways
- Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E,
"Protecting neurons from death during oxidative and neuroexcitotoxic stress is key for preventing cognitive
- GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting
receptor GPR84 as well as formyl peptide receptor 2 (FPR2), receptors expressed in neutrophils, play a key
- Let’s work better together!
📌Our mission is to bring together all key players under one umbrella to co-exist in the @DrGPCR Ecosystem
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
September 2022 "Heterotrimeric G-protein transducin, Gt, is a key signal transducer and amplifier in
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
We analyzed the receptor conformational changes and described interactions within its key regions and
- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
Cholesterol is a key constituent of higher eukaryotic membranes and is believed to contribute to the
- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
It plays a key role in the regulation of human calcium and thus mineral metabolism.
- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
The putative key residues (W274, D95, V267, L139, V263, M142, T260, R146, R258 and others) involving
- A broad look into the future of systemic sclerosis
September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation Fibroblasts are a key effector cell in SSc. Promising nuclear receptors as key regulators of transcriptional programmes will be introduced as well
- Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis
Completion of cytokinesis in the presence of pheromone is promoted by the kelch-repeat protein, Kel1 We found that RGS complexes with Kel1 and prefers the unphosphorylatable RGS mutant. unphosphorylatable RGS exacerbates cytokinetic defects, whereas they are rescued by overexpression of Kel1 These data lead us to a model where Kel1 promotes completion of cytokinesis before pheromone-induced
- Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
Collagen- and GPVI-Dependent Thrombus Formation under Shear "Glycoprotein (GP)VI and integrin αIIbβ3 are key