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146 items found for "Ye K"
- University | Dr. GPCR Ecosystem
GPCR Ecosystem is the ultimate learning platform for expanding your knowledge, making connections, and
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
be useful, but we hypothesized that mathematical modeling could be useful when there is incomplete knowledge Authors Michael Trogdon, Kodye Abbott, Nadia Arang, Kathryn Lande, Navneet Kaur, Melinda Tong, Mathieu
- Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes
Although the mechanism of T2DM is not yet fully known, inflammation and insulin resistance play a central Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression.
- Trainee Symposium II
She then joined Andrew Kruse’s lab for her postdoc in 2018 where she has employed protein engineering
- Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis
engineered tyrDC-deficient Enterococcus faecalis strain and intestinal epithelial cell-specific Adra2a knockout Authors Chaoliang Li , Panrui Zhang , Yadong Xie , Shishan Wang , Meng Guo , Xiaowei Wei , Kaiguang Zhang
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
Identified intolerant residues with reported cancer-linked mutations RGS14-R173C/H and RGS4-K125Q/E126K In downstream cAMP measurement, tolerant RGS14-D137Y and RGS10-S64T and intolerant RGS10-K89M resulted
- Applying Pharmacology to Drug Discovery
Terry Kenakin On Demand 4 modules - 4 hours total Get Started Premium Members benefits: - Subscribe and Agonists Week 3 - Characterizing Antagonists Week 4 - Characterizing Allosteric Modulators Good to know Kenakin during the four weeks, scheduled according to the professor's availability. Terry Kenakin After obtaining a BS in chemistry and PhD in Pharmacology at the University of Alberta,
- RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway
inhibiting Hippo signaling with GA-017 promoted cell proliferation and activated autophagy in RGS20 knock-down
- GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway
helper 17 (Th17) cell differentiation leading to elevated production of interleukin 17 (IL-17) for keratinocytes team allocated GPR97 depletion (GPR97-/-), GPR97 conditional depletion on dendritic cell (DC-cKO), and keratin 14-conditional knockout (K14-cKO) mice models to explore the function of GPR97 which influences keratinocytes In addition, hyperproliferative keratinocytes as well as accumulation of DCs and Th17 cells were detected in imiquimod (IMQ)-induced GPR97-/- mice, which was consistent with the results in DC-cKO and K14-cKO
- Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant
How collective function of these chemokines orchestrates neutrophil recruitment is not known. Authors Kirti V Sawant , Krishna Mohan Sepuru , Brigith Penaranda , Emily Lowry , Roberto P Garofalo , Krishna Rajarathnam Tags GPCR , heterodimer , inflammation , leukocyte , proteoglycan Source Contribute
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
Authors Hsuan Lung, Kelly L Wentworth, Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang, Sunita Ho, Edward C Hsiao Tags Wnt pathway inhibition , fibrotic bone disease , fibrous dysplasia
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
Although BCR-ABL1 mutation is a key cause of CML resistance, understanding mechanisms independent of
- Distinct sub-cellular signal propagation as a component of functional selectivity
Penfield award from the Quebec Government (2017), the innovation award of ADRIQ (2019) and the 2021 Killam
- Ep 15 with Dr. Arun Shukla
Arun Shukla from the Indian Institute of Technology in Kanpur, India. Brian Kolbika of Stanford University. Join us and learn more about Dr.
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
LPS-induced GFs inflammatory state were evaluated by RT-qPCR and Western blotting analysis after GPRC5A knockdown -6, IL-8, tumor necrosis factor (TNF)-α, prostaglandin endoperoxide synthase 2 (PTGS2) after GPRC5A knockdown analysis and immunofluorescence staining were used to further investigate the activation of nuclear factor-kappa Conclusions: GPRC5A expression was upregulated in periodontitis, and GPRC5A knockdown inhibited LPS-induced
- Ep 59 with Dr. Nicola J. Smith
Together with Irina Kufareva , UCSD, her team developed a novel approach to identifying ligands for orphan
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium
Statistical analysis included Kruskal-Wallis test, T-test, or Mann-Whitney U test, according to data
- Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq
Authors Mariana Bustamante Eduardo , Irene Keller , Nathalie Schuster , Stefan Aebi , Rolf Jaggi Tags
- Ep 79 with Dr. Graeme Milligan
His experience also includes translating knowledge generated into the selection of targets, screening and other indications including non-alcoholic steatohepatitis (NASH) and inflammatory diseases and Keltic
- Ep 134 with Dr. Neil Grimsey
Neil Grimsey " During my postdoctoral studies at USCD, I discovered a novel GPCR-dependent atypical kinase We have developed an array of fluorescent biosensors to map kinase activity in living cells and are exploring innovative techniques to delineate the molecular dynamics of atypical p38 and suppress kinase activation
- miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population
By examining the expression of known and novel marker genes, we validated the identity of these clusters
- SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
September 27, 2023 Abstract "Aims: Epidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinases G-protein-coupled receptor (GPCR) with diverse biological functions in humans, and it is upregulated through the NF-KB
- Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
Authors Azusa Yamato, Hidekazu Nagano, Yue Gao, Tatsuma Matsuda, Naoko Hashimoto, Akitoshi Nakayama, Kazuyuki Yamagata, Masataka Yokoyama, Yingbo Gong, Xiaoyan Shi, Siti Nurul Zhahara, Takashi Kono, Yuki Taki, Naoto Furuki, Motoi Nishimura, Kentaro Horiguchi, Yasuo Iwadate, Masaki Fukuyo, Bahityar Rahmutulla, Atsushi Kaneda, Yoshinori Hasegawa, Yusuke Kawashima, Osamu Ohara, Tetsuo Ishikawa, Eiryo Kawakami, Yasuhiro
- Sponsorship Prospectus | Dr. GPCR Ecosystem
as Cinvestav) in Mexico City, offering a dynamic platform for knowledge exchange, collaboration, and Enhance brand visibility and recognition among key stakeholders in the field. Support the advancement of knowledge and collaboration within the scientific community. Opportunity to deliver opening remarks or introduce keynote speakers. Opportunity to sponsor a keynote session or panel discussion.
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- Ep 132 with Dr. Richard Premont
the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout , knock-in and conditional models of mouse physiology and behavior."