analogs Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated

In particular, we demonstrated that two amino acid residues of Map3, F214 and F215, are key residues

(TIMS-TOF MS) A rapid, tag-free way to purify functional GPCRs tANCHOR fast and cost-effective cell-based via Induced Fit Docking and Free Energy Perturbation A computational insight on the aromatic amino acids

linkage of other monosaccharides (Schjoldager KT et al. 2020), and usually capped by a single sialic acid , although, in rare cases glycans can carry polysialylation (PolySia) (Mindler K et al. 2021). Removal of the terminal sialic acid was also shown to negatively impact signaling as previously appreciated

GPCRs in Neuroscience Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane

Content in β-cells in a High Fat Diet-induced Mouse Model of Obesity GPCRs in Neuroscience Xanthurenic acid Holdings Portfolio Company Amolyt Pharma Enters into Definitive Agreement to be Acquired by AstraZeneca Basecamp Research Launches BaseFold: A Breakthrough in 3D Protein Structure Prediction of Large, Complex Protein

company developing novel oral therapeutics to treat a wide range of chronic diseases, today introduced Basecamp

From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction.

selectively activate specific G protein families, others are more versatile, yielding diverse responses based The hypothesis arises that GPCR and β-arrestin-centered effector complexes vary based on subcellular Emerging strategies incorporate unnatural amino acids and crosslinking for structural data inference

., 2011), although it is widely accepted that medium‐chain fatty acids (MCFAs) can bind to and activate

Signaling Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid

Molecular Pharmacology GPCR Events, Meetings, and Webinars October 17, 2024 | Unprecedented fragment-based Drugs, and more Global analysis of neuropeptide receptor conservation across phylum Nematoda Target-based egg-laying circuit Methods & Updates in GPCR Research High-throughput G protein-coupled receptor-based of psychedelic LSD recognition at dopamine D1 receptor Structural basis of μ-opioid receptor targeting interactions of the serotonin1A receptor Potential allosteric pockets identification of glucagon receptor based

neurotransmission and chemokine signaling, extending to numerous other GPCR-regulated systems such as free fatty acid

GPCR Event Spotlight Discovery on Target’s 19th Annual GPCR-Based Drug Discovery Targeting G Protein-Coupled The 19th Annual GPCR-Based Drug Discovery conference (October 2-3, 2024, in Boston and online) gathers 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based critical for the cleavage of the porcine embryo by regulating HSP90 and the AKT pathway Structural basis

neurotransmission and chemokine signaling, extending to numerous other GPCR-regulated systems such as free fatty acid

Using BRET based approaches, the Gs-coupled vasopressin V2 receptor (V2R) was shown to form a stable Proc Natl Acad Sci U S A, 2020. 117(35): p. 21723-21730. 2.     

ADS024 is efficacious in multiple neuroinflammatory disease models Discovery of a potent melatonin-based Approach to Predict Peptide-GPCR Complexes: The N/OFQ-NOP System as a Successful AlphaFold Application Case Molecular Insights into GPCR Function Monitoring GPCR conformation with GFP-inspired dyes Structural basis 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based

function, particularly with respect to biased agonism, which may alter downstream signaling outcomes based Proc Natl Acad Sci U S A, 2012. 109 (45): p. 18607-12. 8.         

Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling Methods & Updates in GPCR Research NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding Biotechnology will be participating in a panel discussion at the LSX World Congress Novel living yeast-based FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based

therapeutic target for neurological and psychiatric disorders GPCR Activation and Signaling Molecular basis receptor by PAF Heterodimers revolutionize the field of metabotropic glutamate receptors Molecular Basis using next-generation GRABNE sensors Structural and Molecular Insights into GPCR Function Structural basis play   GPCR Events, Meetings, and Webinars September 18, 2024 | FREE Webinar - The value of GPCR cell-based

stimulate milk synthesis in mouse mammary epithelial cells GPCR Binders, Drugs, and more Structure-based control: a systematic approach of chemical intervention Methods & Updates in GPCR Research ORP9-PH domain-based medications for problematic alcohol use Structural and Molecular Insights into GPCR Function Structural basis

GPCR Event Spotlight Discovery on Target’s 19th Annual GPCR-Based Drug Discovery Targeting G Protein-Coupled 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based Insights into the structure and activation mechanism of some class B1 GPCR family members Structural basis

., for their work on Conformation- and activation-based BRET sensors differentially report on GPCR-G signaling Exploring the Activation Mechanism of the GPR183 Receptor GPCR Binders, Drugs, and more Target-based Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit midgut contractions Ligand-based Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling Conformation- and activation-based June 25 - 29, 2024 | FENS Forum 2024 NEW September 18, 2024 | FREE Webinar - The value of GPCR cell-based

Here, we report the structure-based development of fluorescent ligands targeting the intracellular allosteric studies, we developed 14 as a fluorescent CCR2 ligand, enabling cell-free as well as cellular NanoBRET-based Further, we show that 14 can be used as a tool for fragment-based screening approaches. Thus, our small-molecule-based fluorescent CCR2 ligand 14 represents a promising tool for future studies

The molecular basis of the antidepressant action of the magic mushroom extract, psilocin. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs Convergent Research - Senior Scientist, Cell-Based

GPCR Binders, Drugs, and more In-depth molecular profiling of an intronic GNAO1 mutant as the basis for FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based

Johannes Broichhagen for their excellent work on Deuteration as a General Strategy to Enhance Azobenzene-Based Publication in Nature Communications Demonstrating First-Ever Structure of a Complex Between an Antibody-based   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based restricted antagonist GPCR Binders, Drugs, and more Deuteration as a General Strategy to Enhance Azobenzene-Based

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs. Structural and Molecular Insights into GPCR Function Structure-based design of novel melanin-concentrating hormone receptor-1 ligands based on saturated nitrogen-containing heterocycles.