Endocrinology, and Taste Propionate functions as a feeding-state-dependent regulatory metabolite to counter pro-inflammatory

The chemokine receptor system is implicated in a wide range of inflammatory, autoimmune and infectious this class, as the majority of potential therapeutic applications are situated in the area of chronic inflammatory

JoAnn Trejo's study 'identifies two deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory

Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer's

GPCR Activation and Signaling Butyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome

in Oncology and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory

Pharmacology, Computer Simulations And Machine Learning To Predict Ligand Signaling Pathways Via The Anti-Inflammatory

Pharmacology, Computer Simulations And Machine Learning To Predict Ligand Signaling Pathways Via The Anti-Inflammatory

Pharmacology, Computer Simulations And Machine Learning To Predict Ligand Signaling Pathways Via The Anti-Inflammatory

Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic.

GPR84 has been shown to be an attractive target in pro‐inflammatory conditions (Gagnon et al., 2018; Regarding the first question, GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders renders it a promising target in inflammatory and fibrotic conditions, including neuroinflammation ( GPR84 has been additionally proposed to be a potential biomarker in different inflammatory diseases (

Past work has produced conflicting results with respect to the effects of pro-inflammatory conditions Thus, we systematically investigated the relationship between the concentration of two distinct pro-inflammatory respect to inhibition of microglia nitric oxide release is dependent on the concentration and type of pro-inflammatory This indicates that different pro-inflammatory stimuli influence the capacity of microglia to synthesize

Both groups of metabolites suppress anti-inflammatory interleukin-10 signaling in human macrophage cell types, but they also suppress the pro-inflammatory interleukin-17A+ population in TH 17-differentiated

signal-regulated kinase [ERK], p38) and redox-sensitive transcription factors (NF-κB) and increased formation of inflammatory OHC-induced allodynia is dependent on MAPK and NF-κB signaling pathways and results in an increase in pro-inflammatory

from RA patients is involved in leukocyte chemotaxis to the synovium "The rheumatoid arthritis (RA) inflammatory Recent evidence indicates that GPR15 may be associated with modulation of the chronic inflammatory response

The ability of CB2 receptors to inhibit dopaminergic and hippocampal circuits, combined with the anti-inflammatory

Aberrant EBI2 signaling is implicated in inflammatory bowel disease, sclerosis, and infectious disease

Orthosteric and allosteric antagonists of C5aR1 are a novel strategy for anti-inflammatory therapies.

constitute an important biochemical axis that influence many cellular pathways involving homeostatic and inflammatory multiple sclerosis, in the recovery from central nervous system injuries, in several chronic, peripheral inflammatory

protein-coupled receptor (GPCR) GPR35 is involved in oncogenic signaling, bacterial infections, and inflammatory modulate GPR35-transducer interactions and allow for mechanism-based therapies against, for example, inflammatory

due to complex interactions among neuropeptides, receptor isoform-specific signaling events, and the inflammatory

identified mechanistically distinct and cell type–specific roles for C3aR in regulating innate immune cell inflammatory

of GLP-1R in human iTreg cells, we hypothesize that GLP-1R+ iTreg cells play a key role in the anti-inflammatory

compared to the C5aR1, which has received enormous attention for its role in both acute and chronic inflammatory

precursor is inactive, but proteases from the coagulation and fibrinolytic cascades, as well as from inflammatory

biopharmaceutical company focused on orally administered therapeutics to treat autoimmune diseases, inflammatory

molecules and monoclonal antibodies for the treatment of cancer, infections, metabolic disorders or inflammatory

increased mRNA and protein levels of collagen I/III with higher levels of reactive oxygen species (ROS) and inflammatory Β-catenin activation and nuclear translocation are associated with increased synthesis of inflammatory