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178 items found for "autoimmune disease"
- 📰 GPCR Weekly News - January 9 to 15, 2023
GPCRs in Cardiology, Endocrinology, and Taste Gender Differences in GRK2 in Cardiovascular Diseases and Manager Director of Molecular Pharmacology, Discovery Biology Staff Scientist/Senior Staff Scientist, Disease
- 📰 GPCR Weekly News, September 25 to October 1, 2023
cellulose-degrading enzymes Functional Water Channels Within the TSH Receptor - a new paradigm for TSH action with disease launch LAB eN², a translational drug discovery accelerator, to address innovation gap in cardiometabolic diseases
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
disaccharide sugar with known pro‐autophagy activity and effective in alleviating diverse inflammatory diseases
- Finding needles in haystacks: Omass unveils pipeline aimed at tough-to-drug targets
intracellular protein complexes and solute carriers, are relevant to immunology indications and rare diseases
- GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
protein-coupled A2A adenosine receptor (A2AAR) have been considered promising agents to treat Parkinson's disease
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
Neisseria meningitidis is a Gram-negative opportunistic pathogen that is responsible for causing human diseases
- VIB spin-off Confo Therapeutics Enters Collaborative Agreement with Regeneron
conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G protein-coupled receptors) in disease-relevant
- 📰 GPCR Weekly News, May 27 to June 2, 2024
knockdown regulates the expression and alternative splicing of genes associated with aphasia-related diseases ochraceus quorum sensing through the GprC-AcyA pathway Deciphering the genetic landscape of lumpy skin disease
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
with the fact that dysregulation of compartmentalized GPCR signaling has been implicated in various diseases aberrant endosomal signaling by GPCRs has been linked to disorders such as cancer, neurodegenerative diseases Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
macrophages and monocytes, and play a critical role in neuroinflammatory conditions such as Alzheimer's disease
- Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System
numerous GPCRs have been studied for their impact on pathologic conditions, including cardiovascular diseases
- Dr. Kevin Pfleger and Dr. Elizabeth Johnstone were awarded one of the 2022 Diabetes Research...
Molecular Endocrinology and Pharmacology Laboratory team who are investigating new ways to tackle the disease-inducing
- 📰 GPCR Weekly News, November 20 to 26, 2023
Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases concept to metabolomics: New insights into pregnenolone function Molecular characterization of lumpy skin disease
- Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
Several S1PR therapeutic drugs have been developed to treat these diseases; however, they lack receptor
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
Retinitis pigmentosa (RP) is a group of hereditary degenerative diseases affecting 1 of 4000 people worldwide
- 📰 GPCR Weekly News, June 26 to July 2, 2023
Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer's and Parkinson's diseases as druggable targets through Withania somnifera bioactives: an in silico study
- Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging...
effects of CB2 receptor activation, make this receptor an intriguing target for treating schizophrenia, a disease
- 📰 GPCR Weekly News, July 1 to 7, 2024
determines the potential of a GPCR for arrestin-biased agonism The roles of RGS proteins in cardiometabolic disease Receptor Responses to Sequential Injections of Pure and Mixed Sweeteners GPCRs involved in metabolic diseases
- Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR
(GPCR) targets with a goal of creating new drug discovery programs in the area of gastrointestinal diseases
- Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization
understanding the modulatory role of the membrane environment on the organization and dynamics of GPCRs in diseases
- GPCR Weekly Whirlwind: Top Receptor Highlights from Sep 30 - Oct 6, 2024!
plant-like” behavior in important human cell regulator, opening up a new drug target for cancer, other diseases Neuroscience Diverse signaling mechanisms and heterogeneity of astrocyte reactivity in Alzheimer's disease
- 📰 GPCR Weekly News, January 15 to 21, 2024
/3 APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease transport by CCHCR1 via direct interaction Industry News Novartis Lutathera® significantly reduced risk of disease
- GPCR Therapeutics welcomes Dr. Ed Brennan as their new Vice President, Head of Clinical Development
phases of clinical development, and across multiple therapeutic areas, including Oncology, Infectious Diseases
- Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
including expensive cost of reagents, optimizing sensor expression levels and adapting these systems to disease-relevant the development of the BERKY and the ONE-GO biosensors, designed to facilitate their application in disease
- Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
protein-coupled receptors (aGPCRs) are keys of many physiological events and attractive targets for various diseases
- Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range of diseases
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
The mGlu5 receptor is a promising target for the treatment of psychiatric and neurodegenerative diseases
- Hop in the Time Machine with GPCR: Unraveling the Future of Research! ⦿ Nov 24 - Dec 1, 2024
Founder & CEO, and Zach Jonasson, CFO & CBO at Absci Octant: A Next Generation Approach to Genetic Disease allosteric communication networks GPTrans: A Biological Language Model-Based Approach for Predicting Disease-Associated