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282 items found for "cAMP signaling"

  • Ep 87 with Dr. Bianca Plouffe

    She identified the structural determinant controlling biased signaling of melatonin type 2 receptors which led to the finding that both β-arrestin and G protein can simultaneously bind to some GPCRs when signaling Funded by a Wellcome Trust Seed Award, she investigated biased and compartmentalized G protein signaling Her subsequent work has focused on understanding the role of compartmentalized Gq signaling by the cytomegalovirus-encoded

  • Ep 34 with Dr. Brian Arey

    the first described synthetic agonists and antagonists of the FSHR and has been an early champion of signaling His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics

  • Ep 35 with Dr. Brian Arey

    the first described synthetic agonists and antagonists of the FSHR and has been an early champion of signaling His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics

  • Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis

    Subsequent signaling analysis reveals a strict requirement of phospholipase C β3 (PLCβ3) and its downstream pioneers a link between Gi/o-coupled GPCRs and TNT development, and sheds light into the intricate signaling pathways governing the generation of specialized actin-rich elongated structures in response to bioactive signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Session VII | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Agenda Session VII Physiological and pathological roles of AGPCRs in the nervous system Uncovering the signaling Interacts With The Notch Pathway To Control Germ Cell Proliferation Willem Berend Post Uncovering the signaling We also aimed at identifying the signaling pathway that Remo is involved in. Remo may serve a role in this peculiar signaling pathway and require further analysis." His research focuses on the relevance of aGPCRs in physiology and signaling using both in vitro and in

  • Itaconate in host inflammation and defense

    In addition to contributing to energetic and biosynthetic demands, metabolites can also function as signaling intracellularly to influence metabolism, oxidative response, epigenetic modification, and gene expression and to signal in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Ep 62 with Dr. Sai Prasad Pydi

    NIDDK) - NIH, USA as a postdoctoral fellow and trained on understanding the physiological role of GPCR signaling GPCR-based drugs for the treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling Sai Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research

  • RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment

    tumor microenvironment Published date November 20, 2023 Abstract " Background: Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor (GPCR) signaling, is highly expressed Yu Song , Wen-Di Zhang , Rui-Juan Guo , Han Li , Mei Han Tags Breast cancer , Regulator of G protein signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells

    October 29, 2024 Abstract "The intestinal lumen is rich in gut microbial metabolites that serve as signaling G-protein-coupled receptors (GPCRs) sense metabolites and can act as key mediators that translate gut luminal signals in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Session IX / Technology capsule: Light on aGPCR signaling and function | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    -25 Download PDF Program HERE < Back to Full Agenda Session IX / Technology capsule: Light on aGPCR signaling

  • G Protein-coupled Receptor-mediated Membrane Targeting of PLCγ2 is Essential for Neutrophil Chemotaxis

    chemoattractant/GPCR-mediated membrane recruitment of PLCγ2 constitutes GPCR-mediated phospholipase C (PLC) signaling The study reveals a molecular mechanism of membrane targeting of PLCγ2 and the signaling pathways by in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Ep 70 with Dr. Stephen Ferguson

    receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor signaling

  • Chemokine Physiology in Cancer

    atypical receptors and non-GPCR binding partners that cumulatively influence discrete pharmacological signaling gradients and illustrate how differences between ligand recognition and receptor activation influence the signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Ep 143 with Dr Davide Calebiro

    engineers and computer scientists focusing on the basic mechanisms of G protein-coupled receptor (GPCR) signalling To study GPCR signalling, they develop and use innovative optical methods based on FRET and single-molecule microscopy, which allow them to directly observe signalling events in living cells and tissues with

  • Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery

    allostery Published date March 10, 2023 Abstract " Understanding the roles of intermediate states in signaling Intermediate-state-trapped mutants will also provide useful information in relation to receptor-G protein signal in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Session I | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Back to Full Agenda Session I Tethered agonist - dependent/independent activation mechanism in AGPCRs Signaling Region with Transmembrane Domain in a Holo-Adhesion GPCR Demet Araç Heterogeneity of Tethered Agonist Signaling It has been suggested that the TA can regulate receptor signaling without coming out of the GAIN domain The TA peptide remains at its original position and is not involved in signaling. Demet Araç on the web Araç Laboratory at UChicago X (Twitter) Heterogeneity of Tethered Agonist Signaling

  • Ep 69 with Dr. Stephen Ferguson

    receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor signaling

  • Ep 112 with Julia Gardner

    In the Rajagopal Lab, Julia studies the mechanisms of 'biased signaling' at GPCRs, with a specific focus translocate to endosomes, and that the subcellular localization of the GRKs affects a GPCR's biased signaling

  • Ep 02 with Dr. Terry Hébert

    Today he and his team are working on understanding receptor signaling in specialized cellular environments favorite GPCR is the angiotensin 1 receptor, especially for its ability to activate a large variety of signaling

  • Ep 30 with Dr. Elva Zhao

    she obtained her Ph.D. at the University of Western Ontario, working on the regulation of G proteins signaling Her current research focuses on class B GPCRs and understanding how GPCR signaling and function is mediated

  • Ep 49 with Dr. Sudha Shenoy

    ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation of signaling Current efforts aim to understand the regulation of GPCR and beta-arrestin signaling in the heart and

  • Ep 110 with Dr. G. Aditya Kumar

    understanding the role of the membrane microenvironment in the subcellular organization, trafficking, and signaling the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling

  • Ep 105 with Annabelle Milner

    Annabelle’s Ph.D. work focuses on microbial-derived metabolites that signal through GPCRs expressed in In particular, she is looking at L- and D-lactate-activated HCAR1 signaling.

  • Ep 71 with Dr. Jean Martin Beaulieu

    Beaulieu has pioneered work establishing a role for Beta-arrestin signaling in the brain in vivo and has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target signaling is presently investigating how cell surface express proteins can act as allosteric modulators of D2R signaling

  • Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans

    exposure to CPPDQ potentially resulted in neurotoxicity by inhibiting TGF-β, JNK MAPK, and ERK MAPK signals The inhibition in JNK MAPK and ERK MAPKs signals in CPPDQ exposed nematodes was further related to alteration in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Session III | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    PDF Program HERE < Back to Full Agenda Session III Molecular tools and biosensors directed at AGPCR signaling Häfner bioSens-All: A Multiparametric BRET-Based Platform for Comprehensive Profiling of adhesion GPCR Signaling and Pharmacology-Enabling Drug Discovery Laurent Sabbagh Characterizing hADGRE5/CD97 Activation and Signaling Laurent Sabbagh on the web Domain Therapeutics Characterizing hADGRE5/CD97 Activation and Signaling: My expertise lies in exploring the biological properties and signaling pathways activated by aGPCRs,

  • Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux

    receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-store-operated Ca2+ (SOC) signaling G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-SOC signaling Tags calcium signaling , infection , interleukin-8 , porcine epidemic diarrhea virus , therapy . in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

    The Department’s strengths lie in GPCR signal transduction and neuroscience, and she has expanded it research focuses on the structure and function of GTP binding proteins and the molecular mechanisms of signal Her laboratory has been involved in studying G protein coupled signal transduction for many years and Current areas of interest include Protease Activated Receptor signaling in the cardiovascular system

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