Wednesday-Friday, 5th-7th October 2022 Place Evotec Campus Levi-Montalcini, Verona, Italy Downloads and Links

Discovery on Target (DOT) highlights advances in current and emerging “hot” targets and technologies, as well

will take place in the heart of Leipzig, which offers a colorful mixture of culture and vivid social life

August 2022 "We are happy to announce you our 2nd IRN i-GPCRnet meeting that will be held at the University of Wurzburg (Germany) from september 30th to october 1rst." Read more at the source #DrGPCR #GPCR #IndustryNews

Before we dive into this week’s news, we’d like to draw your attention to some of our events and resources Autocrine Proteinase-Activated Receptor (PAR) signaling in PC3 prostate cancer cells. & Updates in GPCR Research A Peptidisc-based Survey of the Plasma Membrane Proteome of a Mammalian Cell GPCRs in Immunology and Oncology The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer and Webinars GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training School on “Cell-based

Chakit Arora, J Silvio Gutkind, and Francesco Raimondi for their work on The landscape of cancer-rewired The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell in a murine model with fibrotic bone The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor The landscape of cancer-rewired GPCR signaling axes Methods therapeutic targets Generation of comprehensive GPCR-transducer-deficient cell lines to dissect complexity

October 2022 Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics optimized approach of combining the data derived from steered molecular dynamics simulations and the Bell-Evans

August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational Here, we investigated this issue in living cells for the CC chemokine receptor 5 (CCR5), a major receptor We showed a diversity of ligand-free forms of CCR5 at the cell surface constituted of various oligomeric These results suggest a link between receptor activation and immobilization. Applied to HIV-1 envelope glycoproteins gp120, our quantitative analysis revealed agonist-like properties

” behavior in important human cell regulator, opening up a new drug target for cancer, other diseases Call for GPCR Papers Deadline: Nov 1, 2024. in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell spinal cord injury GPCRs in Oncology and Immunology Biochemical pharmacology of adenylyl cyclases in cancer Therapy Methods & Updates in GPCR Research Protocol for detecting endogenous GPCR activity in primary cell

activate specific G protein families, others are more versatile, yielding diverse responses based on cell-specific This includes proteins like AP-2 and clathrin, vital for internalization, as well as MAPK cascade kinases pathological conditions, including cancer (Gros, R. et al. 2000, Sun, W. (GEPIA) tool, it is evident that β-arrestin expression is dysregulated in many cancer types. signaling pathways governed by β-arrestins, which exhibit increased or reduced activity within distinct cell

in autism spectrum disorders GPCRs in Oncology and Immunology Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq Reviews 2023 Half Year And Second Quarter Financial Results And Provides Corporate Update Sosei Heptares and Cancer Research UK Announce the Dosing of the First Patient in a Phase I/IIa Trial with Cancer Immunotherapy and First Half of 2023 Novo Nordisk to acquire Inversago Pharma to develop new therapies for people living

GPCR Signaling Measurement and Drug Profiling with an Automated Live-Cell Microscopy System. and more Cytotoxicity-related effects of imidazolium and chlorinated bispyridinium oximes in SH-SY5Y cells GPCRs in Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway. Sherwin Sells 30,000 Shares STALICLA signs agreement with Novartis on neurodevelopmental disorders Call

kidney disease GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion. CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes. Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin NEW FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

Submit a 1-minute abstract video and tell us more about your project in this form. Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells GPCRs in Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure Industry News Exscientia Initiates Prospective Observational Study in Ovarian Cancer. Undrugged GPCR Target in Four Months Cumulus Oncology and Leadxpro collaborate on small molecules targeting cancer-focused

But before we delve into the latest news, we'd like to highlight some upcoming events and resources: GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells zoominar (June 22, 2023) NEW Meet Inoviem Scientific Team (June 19 - 23, 2023) Training School on “Cell-based

Cardiology, Endocrinology, and Taste Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype Mesenchymal stromal cell secretory molecules improve the functional survival pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer Methods & Updates in GPCR Research Target immobilization on glass microfiber membranes as Technician Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals Postdoc In Cell

Sakmar and his team used 'bioluminescence resonance energy transfer to measure cell-surface expression of neurodegenerative diseases GPCRs in Neuroscience Primary cilia control oligodendrocyte precursor cell Preclinical Data for AI-designed LSD1 and MALT1 Inhibitors at ESMO 2023 Restoring the function of a human cell surface protein in yeast cells Trevena Reports Favorable TRV045 Topline Safety and Tolerability Data reinforces consistent reduction in risk of recurrence across key subgroups of patients with early breast cancer

GPCRs in Neuroscience The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic GPCRs in Oncology and Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates Colorectal cancer incidence trends in Golestan, Iran: An age-period-cohort analysis 2004-2018. Financing to Advance Pipeline of Novel GPCR-targeted Medicines OMass Therapeutics was shortlisted for ‘Life

underlying atypical chemokine receptor 3 activation RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss Activation of Polycystin-1 Signaling by Binding of Stalk-derived Reviews, GPCRs, and more Lessons from the physiological role of guanosine in neurodegeneration and cancer Novartis continues to deliver strong sales growth and core margin expansion in Q2; raises FY 2024 bottom-line November 5 - 7, 2024 | 16th Annual PEGS Europe   September 18, 2024 | FREE Webinar - The value of GPCR cell-based

If you'd like to present a poster, please submit yours today. GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer. ) Sosei Heptares Receives Approval for Change of Market Listing Segment to the Tokyo Stock Exchange Call (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference.

If you'd like to present a poster, please submit yours today. Endocrinology, and Taste Dietary compounds activate an insect gustatory receptor on enteroendocrine cells Establishment of a CaCC-based Cell Model and Method for High-throughput Screening of M3 Receptor Drugs GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer cells.

Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in MCF7 breast cancer cells. GPCR University's live course with Dr. Terry Kenakin. guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells Reviews, GPCRs, and more The multifaceted functions of β-arrestins and their therapeutic potential

neurological and psychiatric disorders: An in silico approach Opioid modulation of prefrontal cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells Methods & Updates in GPCR Research Cryo-electron microscopy for GPCR research endocrinology and metabolism Reviews, GPCRs, and more Butyrate as a promising therapeutic target in cancer

Cholesterol bound to the amino-terminal permease-like region of LYCHOS, and mutating this site impaired

October 2022 ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to harbored in the ADGLR3-hormone receptor domain (HRM, a common extracellular domain of the secretin-like GIP has been linked to the pathogenesis of diabetes mellitus, and our analyses suggest a potential link showed that functional mutations in the ADGLR3 gene disrupt the standard and wild ADGRL3 structure, most likely

October 2022 Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable

March 2022 " Geneva, Switzerland, March 7, 2022 – Addex Therapeutics (SIX: ADXN, Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, announced today that it will issue its full-year 2021 financial results on Thursday, March 10, 2022. Tim Dyer , CEO, Roger Mills , CMO and Robert Lütjens , Head of Discovery Biology, will provide a business update and review its pipeline during a teleconference and webcast for investors, analysts and media at 16:00 CET (15:00 GMT / 10:00 EST / 07:00 PST) the same day. " Read more at the source #DrGPCR #GPCR #IndustryNews

correlation study of adhesion G protein-coupled receptors as potential therapeutic targets for breast cancer uncover GPR183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells -PH domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate dynamics in living cells Reviews, GPCRs, and more Restoring function to inactivating G protein-coupled receptor variants Scientist Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell