Kevin Wright on his new position as Director of Targeted and Immuno-oncology at GPCR Therapeutics, our the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population Identification of S1PR4 as an immune Kevin Wright Joins GPCR Therapeutics as Director of Targeted and Immuno-oncology Sosei Heptares Adds

platform clinically validated to guide treatment selection in patients with advanced haematological cancers

endogenous ligand CX3CL1, which shows notable potential as a therapeutic target in atherosclerosis, cancer

The molecular mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal

Chakit Arora, J Silvio Gutkind, and Francesco Raimondi for their work on The landscape of cancer-rewired protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor The landscape of cancer-rewired neutrophil biology: inflammation, resolution and beyond Exploring GPCR signaling pathway networks as cancer

receptor (A2AAR) have been considered promising agents to treat Parkinson's disease, inflammation, cancer

Autocrine Proteinase-Activated Receptor (PAR) signaling in PC3 prostate cancer cells. GPCRs in Immunology and Oncology The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer

GPR84 is a Gi‐coupled class A GPCR mainly expressed in immune cells and microglia in the brain (Wojciechowicz Regarding the first question, GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders

An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer Structure pulls off rare IPO, raising $161M 3-drug combo leads to 'unprecedented' response in pancreatic cancer

placentation, uteroplacental malperfusion, oxidative stress, endoplasmic reticulum stress, dysregulated immune

receptors (aGPCRs)-a major family of GPCRs-play critical roles in the regulation of tissue development and cancer

For example, chemotherapy, a powerful standard approach to kill fast-growing cancer cells, has the drawback

is a classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune

GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.

manipulation, and potential use of Opn5 and its homologs Industry News The Leading GPCR Company in Immuno-Oncology reinforces consistent reduction in risk of recurrence across key subgroups of patients with early breast cancer

experimental animals have shown that certain subsets of T cells express functional GLP-1R, indicating an immune

chemotaxis to the synovium "The rheumatoid arthritis (RA) inflammatory process occurs in the joints where immune

Through gene expression analysis in immune and gastrointestinal cells, we show that these isoforms emerge

4256, a Highly Potent and Selective Inhibitor of GPR65, in Presentation at American Association for Cancer GPCR Jobs NEW Director - Targeted Oncology NEW Senior Scientist - Antibody Engineering NEW Scientist—Immuno-Oncology

GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration

mouse neutrophils Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking The Effect of Cancer-Associated Mutations

Nominated for Prestigious Prix Galien USA ‘Best Startup’ Award: Pioneering GPCR-Driven Immunotherapies in Cancer future directions Going rogue: mechanisms, regulation, and roles of mutationally activated Gα in human cancer

from odor perception, and may contribute to the pathogenesis of disorders including brain diseases and cancers

signaling pathway, which is involved in embryonic development and is implicated in various types of cancer

and internalization of G protein-coupled receptors (GPCRs) and it participates in inflammatory and immune

Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer

For instance, aberrant endosomal signaling by GPCRs has been linked to disorders such as cancer, neurodegenerative GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic

GPCRs in Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer