Here we reported the first comprehensive proteogenomic characterization of natural killer/T-cell lymphoma Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated Therapeutic targeting CCR1 showed promising efficacy with EBV eradication, T-cell activation, and lymphoma cell killing in NKTCL organoid.

previously showed that ColI(2.3)+/Rs1+ mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic cell signaling pathway has been implicated in the pathogenesis of FD-like bone, but the specific Wnts and which cells Single-cell RNA sequencing on long-bone stromal cells of 9-wk-old male ColI(2.3)+/Rs1+ mice and littermate controls showed that fibroblastic stromal cells in ColI(2.3)+/Rs1+ mice were expanded. ligands were up- or downregulated in different cellular populations, including in non-osteoblastic cells

and hypoxia on migration, proliferation, invasion, and signaling in 2D and 3D models of breast cancer cell Antagonizing NPY1R and/or NPY5R in hypoxia compared to normoxia more greatly reduced MAPK signaling, cell proliferation, cell migration and invasion, and spheroid growth and invasion. The estrogen receptor positive MCF7 cells were significantly less invasive in 3D spheres when NPY5R was There were some discrepancies in the responses of each cell line to the isoform-specific antagonists

Experimental design: We performed targeted sequencing, high-throughput drug screening, and single-cell genomic profiling on leukemia cell samples derived from patients with AML. understand the co-occurring mutation patterns and further investigated the mutation profiles in the single cells The application of single-cell genomic sequencing unveiled the co-occurrence of variants at the individual cell level, highlighting the presence of distinct subclones within patients with AML.

Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune cells Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc This model helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently fatty acids Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Chemokines are chemotactic cytokines whose canonical functions govern movement of receptor expressing cells chemokines play paradoxical roles in both the directed emigration of metastatic, receptor-expressing cancer cells out of the tumor as well as immigration of tumor infiltrating immune cells that culminate in a tumor Authors Donovan Drouillard, Brian T Craig, Michael B Dwinell Tags Chemokine receptor; cell migration; Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

In this scenario, metabolite-sensing G-protein coupled receptors (GPCRs), involved in several biological of GPR109A was studied in depth and increased expression of this receptor was detected in epithelial cells and cells from lamina propria, including CD68+ macrophages, in IBD patients. macrophages Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago; 2. Demet Araç "Demet was an undergraduate at Bilkent University in Turkey, where she majored in Molecular Biology Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins independent research career at the University of Chicago within the Department of Biochemistry and Molecular Biology which, four papers were published in Nature (2022a, 2022b, 2021, 2020); one paper was published in Cell

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models

CELSRs regulate planar cell polarity, including the closure of the neural tube. Despite numerous cell and animal studies, molecular details on CELSR proteins are sparsely available, precluding an integrative understanding of CELSR biology. P., Shearer, Tanner, Sando, Richard C.*, and Araç, Demet* Department of Biochemistry and Molecular Biology I study adhesion GPCRs using structural biology perspective and I am interested in how the large multidomain

receptors, are the targets of multiple drugs displaying anti-growth effects in large-scale, cancer cell , Guanming Wu, Gioacchino Natoli, J Silvio Gutkind , Francesco Raimondi Tags GPCR , cancer , cancer cell lines , cell-cell communication , drug repurposing , personalized medicine , signaling network , survival Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Increasing evidence reveals the heightened expression of olfactory receptors in tumorous tissues and cells Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing Guo-Tai Wang Tags G Protein-coupled receptors , Olfactory receptors , Therapeutic targeting , Tumor cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

protein-coupled receptors (GPCRs), enhancing proliferation, adhesion, and migration in many types of cancer cells Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell In these cells, the mitogenic activity of LPA is mediated by LPA Receptor 1 (LPAR1), a GPCR. In some model systems, CCN1 and CCN2 play key roles in LPA/S1P-induced cell migration and proliferation Kathryn E Meier Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Mesenchymal cells play key roles in numerous developmental processes. subunits Gαq and Gα11 (Gαq/11) transmit mechanical and chemical signals to activate TGFβ in epithelial cells exhibited abnormal alveolar development, with suppressed myofibroblast differentiation, altered mesenchymal cell synthetic function, and reduced lung TGFβ2 deposition, as well as kidney abnormalities. undescribed mechanism of cyclical stretch-induced Gαq/11-dependent TGFβ2 signalling in mesenchymal cells

Depletion of GPR37 significantly reduced CRC tumor cell growth both in vitro and in vivo. Further tests showed that GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1 SCD1 , p38 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Mathematical models of biochemical reaction networks are an important and emerging tool for the study of cell Overall, this work highlights the power of mechanism-based computational systems biology as a discovery Edward C Stites Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated migration of B cells recruits a specific GRK to chemoattractant receptors and plays an important role in the control of B cell Authors Taiichiro Shirai , Akiko Nakai , Kazuhiro Suzuki Tags B cell migration , COMMD3/8 complex , GRK Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for therapeutic interventions, including monoclonal antibodies, CAR-T cells, and T-cell engagers. Liu, Fei Xu Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

We examined the prenylation of carboxy-terminus (Ct) mutated Gγ in cells exposed to Fluvastatin and prenyl monitored the subcellular localization of fluorescently tagged Gγ subunits and their mutants using live-cell Given the cell and tissue-specific expression of different Gγ subtypes, our findings indicate a plausible mechanism allowing for statins to differentially perturb heterotrimeric G protein signaling in cells prenyltransferases , statin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

human protein atlas database, we inferred the most predominant GPCR-mediated microbial metabolite-human cell permeability of the small-molecules we elucidated their molecular interactions with specific human cell receptors, particularly expressed on human intestinal epithelial cells, immune cells and the nervous Metabolites Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Individual cells trend to adapt environmental changes in a "whole" flora through communications, allowing Furthermore, GprC and AcyA regulate the primary metabolism as well as secondary metabolism, and further These studies highlight a crucial G protein signaling pathway for cell communication that is mediated ochraceus, hoping to achieve comprehensive prevention and control of mycotoxin pollution from interrupting cell Authors Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication

Whereas it is well established that single-cell migration is often guided by gradients of chemokines Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and patterns to the size and geometry of the environment, and provide a guidance cue for other comigrating cells Michael Sixt Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

PAXIP1-AS1) was found to promote proliferation, migration, EMT, and apoptosis of ovarian cancer (OC) cells in OC cell lines, but the relationship between PAXIP1-AS1 expression and clinical characteristics, prognosis QRT-PCR was used to validate the expression of PAXIP1-AS1 in OC cell lines. PAXIP1-AS1 was significantly downregulated in OC cell lines compared with IOSE29 cell line. , Hui Liu Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell disrupted their engagement with GIV/Girdin, thereby blocking noncanonical G-protein signaling in tumor cells and inhibiting proinvasive traits of metastatic cancer cells. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Here, we showed that US28 increased the malignancy of U251 glioblastoma cells by enhancing signaling Enhanced S1P signaling promoted glioblastoma cell proliferation and survival by activating the kinases US28 also activated the S1P signaling axis in HCMV-infected cells. Authors Nick D Bergkamp , Jeffrey R van Senten , Hendrik J Brink , Maarten P Bebelman , Jelle van den Martine J Smit Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call