Replication by Regulating Ca2+ Flux Published date May 29, 2023 Abstract "Chemokine production by epithelial cells coronavirus porcine epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Laboratories cell-porcine kidney 1 epithelial cells (LLC-PK1). Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Promotes Osteogenic Differentiation Published date May 30, 2023 Abstract "Objectives: Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cell possessing self-renewal and multilineage differentiation Materials and methods: The viability and apoptosis of human DPSCs (hDPSCs) were determined using Cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis and PKC via the signaling pathway of miR-19a/GRK6/GPR39/PKC, which accordingly resulted in suppressed cell apoptosis and promoted cell migration and invasion. scRNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

polarity (PCP) pathway, which establishes and maintains cell and tissue polarity along the tissue plane We initially tested the ADC using in vitro WST-8 viability assays in human GBM cell lines and cell types We observed significantly lower LD50 values in patient-derived and U87 GBM cell cultures vs. CD97-lacking cells. We also found significantly lower LD50 values when treating human GBM cells with the ADC (0.6788 nM),

complications with BCMA-directed therapies in multiple myeloma Published date May 31, 2024 Abstract "B-cell-maturation-antigen single-center analysis we evaluated infectious complications after BCMA-targeted chimeric-antigen-receptor T-cell Comparing T-cell redirecting therapies, the incidence rate of severe infections was significantly lower M Lesokhin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

In response to a chemoattractant stimulation, cells lacking PLCγ2 (plcg2kd) displayed altered dynamics phosphorylation and cofilin activation; impaired dynamics of actin polymerization; and consequently, defects in cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

G protein-coupled receptors (GPCRs) are involved in endocrine and metabolic processes as well as many increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation in 3T3-L1 cells Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

ovarian cancer prognosis Published date June 18, 2024 Abstract " Background: Ovarian cancer (OV) is a common G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated The levels of GPCRRGs were examined in normal and OV cell lines using quantitative reverse-Etranscription epithelial Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

GPCR Community Presentation Breaking Barriers: My Journey from Mexico to the Heart of the Dr. focuses on understanding the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic endothelial cells

This activation promotes neurogenic differentiation of neural stem cells, neurite growth, and synaptogenesis Under nutrient depletion, the model choanoflagellate Salpingoeca rosetta forms distinct cell types that We found that the knock-out of cupidon induces a gain in cell adhesion and cell fusion, resembling the mating behavior of wild-type cells under nutrient depletion. Cupidon mutants, similar to starved wild-type cells, upregulate various extracellular matrix-related

Beatriz Blanco Redondo The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Collectively these proteins form a cell surface complex that acts as a recognition platform for Wnt ligands Scholar X (Twitter) The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Anette 4, Ließmann Fabian 5, Meiler Jens 5, Schöneberg Torsten 2,6, Prömel Simone 1 1 Institute of Cell Willem Berend Post on the web Cell Biology LinkedIn < Previous Session Next Session >

roles of AGPCRs in the periphery ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells health and disease Douglas Tilley ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells Centre for Experimental Medicine, Institute for Biocehmistry and Molecular Cell Biology, University Medical Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2012 - 2015 Postdoctoral fellow, Department of Cell impact cardiac structure and function, and has evolved to encompass their roles in regulating immune cell

To Their Niche And Leads To Myeloid Skewing Emmanouil Kyrloglou A single cell GPCR map of thermogenic G-protein-coupled receptors, which exhibit large multi-domain extracellular N-termini that mediate cell-cell and cell-matrix interactions. Renal Adgrf5 is restricted to two distinct populations of cells: AICs and endothelial cells (ECs). These data demonstrate that Adgrf5 transcript variants are cell-specific in the kidney.

FRET and single-molecule microscopy, which allow them to directly observe signalling events in living cells Davide’s work has been published in prestigious scientific journals such as Nature, Cell, New England Journal of Medicine, Journal of Clinical Investigation, PLoS Biology, PNAS, Nature Communications and

research interests lies in the elucidation of signal transduction pathways in cancer, immune and bone cells area of interest has been the elucidation of the molecular basis for a rare autosomal human disease called The Rottapel lab has shown that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell

Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used , RNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

of Technology in Genova, Italy (2008-2016) and an Associate Research Professor in the Department of Cell Before joining the Department of Cell Biology in 1996 as a postdoc and becoming faculty at Duke in 2000 As of August 2022, he has over 270 publications in scientific journals (including Science, Nature, Cell

GPCR Ecosystem About Monserrat Avila Zozaya I am a cell biologist interested in studying GPCRs, especially developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

co-founder of InterAx Biotech, where he specializes in the development of a technology platform deciphering cell about the intricacies of cell signaling and chemokine receptors. Yamina shared her research experience, emphasizing the fascination of understanding how cells respond significance of interdisciplinary teamwork in drug and technology development, noting the challenges of communication job opportunities at Interax Biotech, with Aurelien Rizk and Yamina clarifying that job openings are communicated

Yuling Feng The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell Stephen, Caron Kathleen M Department of Cell Biology and Physiology at UNC Chapel Hill 111 Mason Farm Van Meir’s research examines how genetic alterations and hypoxia induce changes in cell biology that To address these gaps in knowledge, we used biochemical and cell-biological approaches using cell-lines

inflammation is characterized by overexpression and heightened activity of type 2 cytokines, mediators and cells FeNO , Fractional exhaled nitric oxide , G-protein-coupled receptor , GPCR , Group 2 innate lymphoid cell , IL-31RA , IL-33R , IL-4Rα , IL-5Rα , ILC , ILC2 , IRF1 , IgE , Immunoglobulin E , Innate lymphoid cell immunoglobulin-like lectin 8 , Signal transducer and activator of transcription , Substance P , T helper type 2 cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

in Physiology or Medicine for their discovery of G-proteins and their role in signal transduction in cells hooked and has since studied receptor function in human physiology, receptor molecular pharmacology in cells

developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

2022 Abstract The rheumatoid arthritis (RA) inflammatory process occurs in the joints where immune cells evaluated the expression of GPR15 and GPR15L in blood and synovial tissue samples from RA patients, as well synovial fluid and peripheral blood were analyzed for CD45+CD3+CD4+GPR15+ and CD45+CD3+CD8+GPR15+ T cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell While CXCR4 couples to G proteins and directly promotes cell migration, ACKR3 is G protein-independent single-molecule FRET Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs Tags Breast cancer , Regulator of G protein signaling 5 , Vascular remodeling , Vascular smooth muscle cells Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Results show that the elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these UCA1 , lncRNA Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

of GPR109A was studied in depth and increased expression of this receptor was detected in epithelial cells and cells from lamina propria, including CD68+ macrophages, in IBD patients. macrophages Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call