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studies to address the functional role of these dramatic conformational changes and the relationship to disease continues to engineer the enzyme to optimize its potential as a treatment for cocaine abuse, a debilitating disease

neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's disease

physiological and pharmacological principles that underlie the workings of adhesion GPCRs in health and disease

development of new therapeutic interventions for the alleviation of L-DOPA-induced dyskinesia in Parkinson’s Disease

neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's disease

and pharmacology can provide new opportunities to improve our understanding of human physiology and disease

Confo Therapeutics ) as a team and project leader for antibody discovery for metabolic and inflammatory diseases

of growth factors and their signaling mechanisms in development, adult tissue homeostasis, and human diseases

CCR1 and CCR5 Published date November 23, 2023 Abstract "Inflammatory chemokines are often elevated in disease

Colorectal cancer (CRC) is a prevalent malignant tumor worldwide, leading to significant morbidity and disease

in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases

neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's disease

humoral immunity and discuss the potential of the COMMD3/8 complex as a therapeutic target for autoimmune diseases

expressed NPFF, these findings could have broad implications in various infectious and inflammatory diseases

laboratory has gained valuable insights into the genetic basis and pathophysiology of lymphatic vascular disease , preeclampsia and sex-dependent cardiovascular disease.

Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing

small molecules can selectively disable noncanonical mechanisms of G-protein activation dysregulated in disease

second area of interest has been the elucidation of the molecular basis for a rare autosomal human disease

Despite advances in the treatment, many patients experience disease relapse or become refractory to treatment

were shown to be very effective to rescue the cell death observed in a mouse model of Huntington’s disease

where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease

Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb

where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease

where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease

where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease

Exosomes transport a variety of macromolecules and modulate intercellular communication in physiology and disease

essential in regulating GPCR signaling, and most members are implicated as critical nodes in human diseases

cancer Published date June 24, 2024 Abstract "Pancreatic ductal adenocarcinoma (PDAC) remains a dreadful disease