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105 items found for "double mutant cycle analysis"
- Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer
Our earlier transcriptomic analysis identified Urothelial Carcinoma Associated-1 (UCA1) as an LPA-stimulated
- G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions
To this end, we focused on analysis of bacterial metabolites that are currently recognized to bind to
- Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus
The docked scores of Complex 1, Complex 2, and Complex 3 were validated using MD simulation analysis,
- Classified News | Dr. GPCR Ecosystem
receptor identifies small molecules that inhibit midgut contractions Read More October 8, 2024 Global analysis
- Comparison of infectious complications with BCMA-directed therapies in multiple myeloma
In this retrospective, single-center analysis we evaluated infectious complications after BCMA-targeted
- Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer
Speculatively, previous studies on gene expression analysis of RHBDF2 showed heterogenous behaviour during
- Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
expressed genes (DEGs) in an acute lung injury (ALI) model were identified, and functional enrichment analysis
- Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
Ceddia 1, *, Zack Zurawski 2,3,*, Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer This is one of the top Pharmacology departments in the country, judged by reputation, citation analysis
- GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
To determine GPR68 inhibition's mechanism of cell death we use DAVID pathway analysis of RNAseq.
- GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer
In the present study, expression analyses of GPR176 are performed in patients with colorectal cancer.
- GprC of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells for nematode hunting
Gene-expression analyses revealed that ascarosides activate the fungal GPCR, GprC, at the plasma membrane
- Ep 148 with Dr Arthur Christopoulos
Arthur Christopoulos " Arthur Christopoulos is the Professor of Analytical Pharmacology and the Dean Toxicologists; the British Pharmacological Society’s Gaddum Memorial Award; the IUPHAR Sir James Black Analytical Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & Arthur shared three significant moments that shaped his career, including the evolution and impact of analytical pharmacology, particularly highlighting the role of Prism, a data analysis tool.
- Ep 144 with Dr Aurélien Rizk
Gebhard Schertler, he developed methods for kinetic mathematical analysis of GPCR signaling.
- Ep 149 with Dr Arthur Christopoulos
Arthur Christopoulos " Arthur Christopoulos is the Professor of Analytical Pharmacology and the Dean Toxicologists; the British Pharmacological Society’s Gaddum Memorial Award; the IUPHAR Sir James Black Analytical Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & Arthur shared three significant moments that shaped his career, including the evolution and impact of analytical pharmacology, particularly highlighting the role of Prism, a data analysis tool.
- LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice
Kinome analyses and validation of elected kinase inhibition indicated that LP2-mediated AT 2 R stimulation
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Analysing the main members of the PDAC extracellular purinome using publicly available databases discerned
- CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation
Inflammation was analysed by measuring the release of inflammatory cytokines.
- Ep 106 with Dr. Bruno Giros
Bruno Giros on the web Dougles Research Center LinkedIn Google Scholar Researchgate Dr.
- Ep 142 with Dr Claudia Stäubert
scientific horizon and focused on cellular metabolism and drug resistance phenomenon applying metabolomics analyses
- Trademark Policy | Dr. GPCR Ecosystem
For the avoidance of doubt, this prohibition includes, but is not limited to, any use of pixels, cookies For the avoidance of doubt, Publishers may direct users to a Dr. FindYooour may analyze Publishers' use of a Dr. permission to utilize an automated software program, often called a "web crawler," to retrieve and analyze
- Ep 154 with Dr Badr Sokrat
the importance of individuals struggling with imposter syndrome learning to set aside their fears and doubts
