The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel "off" response. Mammalian type Opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium response

7 (TMH7) and the highly conserved NPXXY motif can be subject to different conformational changes in response

P2RY12 and ameliorates deep venous thrombosis by counteracting neutrophil NETosis and inflammatory response

interaction of arrestins with G-protein coupled receptors (GPCRs) desensitizes agonist-dependent receptor responses

how cells integrate signals from a variety of information-coding molecules into complex orchestrated responses cell to cell communication occurs mostly through neurotransmitters and hormones, and receptors are responsible

Vraniak served as Chief Financial Officer of Evaxion Biotech A/S, an AI enabled immuno-oncology company

vasopressin V2 receptor (V2R) was shown to form a stable complex with the non-cognate G12 protein in response signalling through the non-cognate Gq was not important for the increased β2AR-Gs-mediated cAMP levels in response

either limit chemokines spatial availability or to remove them from in vivo sites, while maintaining the responsiveness described for ACKRs which work in a team with canonical chemokine receptor to drive regulated immunological responses Scavenging may allow cells to continuously migrate by remaining responsive to chemokines (S. Volpe et al. 2012); it dampens the inflammatory response when needed (C. A. H.

In this model, OB-004 showed powerful efficacy, achieving full blockade of monocyte recruitment in response PROcisionXᵀᴹ discovery platform Structure-based validation of Orion’s approach Zheng, Y. et al. (2017) Immunity

dysregulation, contributing to modest blood pressure elevation and exaggerated cardiac hypertrophic response

and Mikel Garcia-Marcos for their work on Smooth operator(s): dialing up and down neurotransmitter responses Physiology by Genomic Fine-Tuning of GPCR Functions Smooth operator(s): dialing up and down neurotransmitter responses

highly selective novel GPR52 agonist HTL00411718 to modulate centrally mediated locomotor activity in response

abundant G protein coupled receptor (GPCR) in the central nervous system, which mediates the functional response

on Protocol to investigate G protein-coupled receptor signaling kinetics and concentration-dependent responses yeast Protocol to investigate G protein-coupled receptor signaling kinetics and concentration-dependent responses

The opioid system is one of the most important in regulating the response to nociception, i.e. the response peripheral nervous system and regulate important physiological functions such as analgesia, stress response

and the targeting of oligomers, which may increase drug discovery success and enhance the therapeutic response

and the targeting of oligomers, which may increase drug discovery success and enhance the therapeutic response

Experimental approach: We used a series of behavioural assays to evaluate the acute responses of mice

assembly of the catalytic domain and providing the means for direct regulation of catalytic activity in response

To elucidate the molecular mechanisms responsible for these effects of RNA editing, we present four active-state

It has been discovered in recent years that inflammatory responses are particularly important in subacute

transcriptional regulation, and more, PKA signaling regulates cellular metabolism and emotional and stress responses

Such studies revealed that tissue response to a given dose of the hormone or its antagonist depends on

August 2022 "Host response to infection involves the activation of the complement system leading to the

Multiple 14-3-3 isoforms exist, and a GPCR can differentially interact with different 14-3-3 isoforms in response

She has played an active role during the COVID-19 pandemic as the UKRI’s COVID Response Director, and

results are supported by our recent work and present observations that show polymerization of G-actin in response

results are supported by our recent work and present observations that show polymerization of G-actin in response