Search Results

focused on the development and commercialization of novel medicines for patients with central nervous system

Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems

Vraniak served as Chief Financial Officer of Evaxion Biotech A/S, an AI enabled immuno-oncology company

function Latrophilins are highly conserved Adhesion GPCRs playing essential roles in the mammalian nervous system Latrophilin-1 acts in trans to mediate morphogenesis of sensory structures in the C. elegans nervous system

PROcisionXᵀᴹ discovery platform Structure-based validation of Orion’s approach Zheng, Y. et al. (2017) Immunity 11. https://doi.org/10.1126/scitranslmed.aav5519 · Demonstration of the in vivo efficacy of a systemically

receptor (B2R) is an essential G protein-coupled receptor (GPCR) that regulates the cardiovascular system

protein-coupled receptors (GPCRs) act as molecular sensors central to all cellular and physiological systems complexity raises further fundamental questions and challenges in the study of GPCR action in multiple systems

Although hypothetical, the reconstruction of the rod phototransduction system highlights the potential

1 receptor interaction "Background and purpose: To fully elucidate the regulatory role of the GLP-2 system Searching for antagonist activity, we performed systematic N-terminal truncations of human GLP-2(1-33

explore the signaling pathways, dynamic structures, and physiological relevance in the cardiovascular system

high-resolution techniques to investigate peptidergic transmission and expression throughout the brain in model systems

Structure-guided design of a peripherally restricted chemogenetic system Hye Jin Kang , Brian E Krumm Methods & Updates in GPCR Research Structure-guided design of a peripherally restricted chemogenetic system

This work highlights an important interplay between the adenosinergic and dopaminergic systems and suggests

focused on the development and commercialization of novel medicines for patients with central nervous system

focused on the development and commercialization of novel medicines for patients with central nervous system

cannabinoid CB1 receptor is the most abundant G protein coupled receptor (GPCR) in the central nervous system

focused on the development and commercialization of novel medicines for patients with central nervous system

small molecule drugs known as allosteric modulators is being explored for treating central nervous system

This review discusses the specific tissue expression of the components of the chemerin system, and the

Although such pheromone/receptor systems are likely to function in both mate choice and prezygotic isolation might reflect the significantly distinct stringency/flexibility of their respective pheromone/receptor systems

neurogenesis, learning and memory, gastrointestinal motility, glucose/lipid metabolism, the cardiovascular system endogenous agonist of GHSR1a, is primarily located in the stomach and is absent from the central nervous system

with the β-arrestin1 N-lobe, in agreement with structural data obtained with chimeric or synthetic systems

October 2022 "Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology

adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system

October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system

class C G protein-coupled receptor (GPCR) heterodimer, plays a crucial role in the central nervous system

the G-protein interface "Galanin is a neuropeptide expressed in the central and peripheral nervous systems

antibody fragments from camelids, have become indispensable tools for interrogating GPCRs both in purified systems