His main research group centers on the function, structure, and regulation of G protein-coupled receptors (GPCRs) and their interacting proteins. into the selection of targets, screening, and identification of small molecule regulators of these proteins

Migration Published date June 25, 2023 Abstract "Bombesin receptor subtype-3 (BRS3) is an orphan G-protein Harvested cellular proteins were digested and phosphopeptides were enriched by immobilized titanium ( Data analysis revealed that 27 phosphopeptides corresponding to six proteins were involved in the Hippo by BRS3 activation could induce the dephosphorylation and nucleus localization of the Yes-associated protein

The unique DRF motif of CXCR6 facilitates leukocyte adhesion by interacting with cell surface-expressed CXCL16 and plays a key role in G-protein selectivity during receptor signalling; however, our findings These substitutions at the DRF motif affect the receptor-Gi/o protein interaction.

GPR143 interacts with HRS (an ESCRT-0 Subunit) and promotes its association to cargo proteins, such as EGFR, which subsequently enables selective protein sorting into intraluminal vesicles (ILVs) in multivesicular ESCRT pathway promotes secretion of exosomes that carry unique cargo, including integrins signaling proteins These findings provide a mechanism for regulating the exosomal proteome and demonstrate its ability to Taejoon Kwon , Pann-Ghill Suh , Young Chan Chae Tags GPR143 , HRS , MVB , breast cancer , exosomal protein

The C5aR1 is a classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune cell activity potentially through β-arrestins rather than G-proteins. function of the C5aR2 is actively debated in the context of C5aR1, even though both C5aR1 and C5aR2 are coexpressed Das, Pulkit K Gupta, Soumendra Rana Tags C5a; C5aR2/C5L2 receptor; lipid bilayer; molecular dynamics; protein-protein

function Structural Determinants Of GAIN Domain Autoproteolysis And Cleavage Resistance Of Adhesion G Protein-Coupled Pohl Abstract "The GPCR autoproteolysis-inducing (GAIN) domain is a hallmark feature of adhe-sion G-protein Despite numerous cell and animal studies, molecular details on CELSR proteins are sparsely available, full-length CELSR1 and truncation constructs to assess the adhesive and signaling functions of this protein A previous computational study has uncovered variable flexible protein regions, whose dynamics mediate

to Attain Trabecular Identity Andrew Dates Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled and neuroimmune alterations during neurodevelopment Rashed Rezwan Parag Novel isoforms of adhesion G protein Receptors Hailey Steichen Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript Variants BAI3) in WNT-Activated Medulloblastomas Alex Torrelli-Diljohn Investigating The Role of ADGRB3 Loss of Expression cardiac health and disease Frank Kwarcinski Discriminating between the extracellular scaffolding and G protein

regulate a wide spectrum of endocrine tumors Published date September 23, 2024 Abstract "Aberrant G-protein coupled receptor (GPCR) expression is highly prevalent in cortisol-secreting primary bilateral macronodular The aberrant expression of diverse GPCRs and their ligands play an important role in the over-function Examples include aberrant expression of MC2R, 5-HT4R, AVPR1A, LHCGR, and GnRHR in primary aldosteronism The genetic mechanisms causing the ectopic expression of GIPR in cortisol-secreting PBMAHs and unilateral

polyangiitis , European Medicines Agency , FDA , FcεRIα , FeNO , Fractional exhaled nitric oxide , G-protein-coupled alpha , JAK , JAK inhibitors , JAKi , Janus kinase , MAPK , MCP-4 , MRGPRX1 , Mas-related family of G protein-coupled receptor 11 , Mas-related family of G protein-coupled receptor X1 , Mas-related family of G-protein-coupled receptor 3 , Mas-related family of G-protein-coupled receptors , Mitogen-activated protein kinase , Monoclonal antibody , Monocyte chemoattractant protein-4 , MrgprA , MrgprA3 , MrgprCr11 , NGF , NMU ,

neuroscience, and she has expanded it in the areas of drug discovery and structural biology of membrane proteins Her research focuses on the structure and function of GTP binding proteins and the molecular mechanisms Her laboratory has been involved in studying G protein coupled signal transduction for many years and has made key discoveries in G protein structure and mechanisms of activation by GPCRs and activation clocks and melatonin synthesis in the avian retina; her postdoctoral work investigated the role of the G protein

While CXCR4 couples to G proteins and directly promotes cell migration, ACKR3 is G protein-independent kinases (GRKs) and β-arrestins and promiscuously responds to CXCL12, CXCL12 variants, other peptides and proteins The dynamic properties of ACKR3 may underly its inability to form productive interactions with G proteins

< GPCR News < GPCRs in Oncology and Immunology GPR15 expressed in T lymphocytes from RA patients is involved GPR15 is a G protein-coupled receptor (GPCR) located on chromosome 3 and has similarity in its sequence We evaluated the expression of GPR15 and GPR15L in blood and synovial tissue samples from RA patients The expression of GPR15 and c10orf99/gpr15l mRNA was analyzed by RT-qPCR. A higher expression in the mRNA for GPR15 was identified in early RA subjects.

Finally, we identified that G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate PEDV induces IL-8 expression to elevate cytosolic Ca2+, promoting its infection. We found that IL-8 expression improved cytosolic Ca2+ in epithelia, facilitating PEDV rapid internalization and egress. G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-SOC signaling

pharmacology and his research program focuses on the molecular and cellular mechanisms regulating G protein-coupled He has developed innovative methods for in-cellulo measurement of protein-protein interactions, receptor

submissions in structural biology, biophysics and biochemistry, with a particular focus on membrane proteins and protein folding."

NPFF regulates a variety of physiological functions by binding to a G protein-coupled receptor (GPCR) However, to date, the expression and/or function of NPFF/NPFFR2 in EOC is undetermined. NPFF treatment upregulates matrix metalloproteinase-9 (MMP-9) expression. In addition, blocking the activation of ERK1/2 signaling abolished the NPFF-induced MMP-9 expression This study provides evidence that NPFF stimulates EOC cell invasion by upregulating MMP-9 expression

Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking His research career has focused on the investigation of the regulation of G protein-coupled receptors

and Systems Research (IMSR) of the University of Birmingham and Co-Director of the Centre of Membrane Proteins biologists, chemists, physicists, engineers and computer scientists focusing on the basic mechanisms of G protein-coupled also at intracellular sites and that these receptors interact among themselves and with other membrane proteins

Since then, he has been studying the allosteric modulation and activation mechanism of this family of G protein-coupled to new concepts in the GPCR field, such as the activation of cell surface receptors by intracellular proteins

Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking His research career has focused on the investigation of the regulation of G protein-coupled receptors

< GPCR News < GPCRs in Oncology and Immunology GPR37 expression as a prognostic marker in gliomas: a GPR37 is an orphan G protein-coupled receptor (GPCR) that is implicated in different physiological pathways Results: GPR37 expression was significantly higher in the glioma tissues compared to the normal brain TIMER2.0 and ssGSEA showed that GPR37 expression was significantly associated with the infiltration of Finally, hypomethylation of the GPR37 promoter was associated with its high expression levels and poor

< GPCR News < GPCRs in Oncology and Immunology Autocrine proteinase-activated receptor signaling in PC3 G protein-coupled receptors (GPCRs) activated by limited n-terminal proteolysis. PARs are highly expressed in many cancer cells, including prostate cancer (PCa), and regulate various , we examined the androgen-independent human prostatic cancer cell line PC3 and find the functional expression We found several genes that are known PCa prognostic factors or biomarker to be differentially expressed

Exposure to CPPDQ (0.01-10 μg/L) further decreased expressions of daf-7 encoding TGF-β ligand, jnk-1 Additionally, among examined G protein-coupled receptor (GPCR) genes, exposure to CPPDQ (0.01-10 μg/L ) decreased dcar-1 expression and increased npr-8 expression. Moreover, in CPPDQ exposed nematodes, RNAi of dcar-1 decreased jnk-1 and mpk-1 expressions, and RNAi of npr-8 increased mpk-1 expression.

targets for cancer therapy focused on the assumption that one gene is responsible for producing one protein Furthermore, proteases have an integral role in cell proliferation and growth because the proteolysis Therefore, an inactive rhomboid protease known as iRhom2 encoded by the gene RHBDF2 can be considered Speculatively, previous studies on gene expression analysis of RHBDF2 showed heterogenous behaviour during switches back to the canonical isoform, and the proteasomal degradation pathway and cytoplasmic ribosomal protein

identified the molecular mechanisms involved in the opposite regulation of dopamine D1 and D5 receptors by protein structural determinant controlling biased signaling of melatonin type 2 receptors in the context of protection Robert Lefkowitz , which led to the finding that both β-arrestin and G protein can simultaneously bind Funded by a Wellcome Trust Seed Award, she investigated biased and compartmentalized G protein signaling

Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors is a tag for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a

Product Manager at Gator Bio , a biotechnology company providing solutions to researchers studying protein-protein

By examining the expression of known and novel marker genes, we validated the identity of these clusters and characterized their gene expression profiles. We found that each cell type could be characterized by a unique expression profile of ion channels, GPCR signaling molecules, synaptic vesicle cycle proteins, and cell adhesion molecules.