Published date March 1, 2024 Abstract "Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2) is a G protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling molecules , such as protein kinase A (PKA), phosphatidylinositol 3-kinase (PI3K), and phospholipase C.

Neuropeptide Y (NPY) is an abundant neurohormone in human breast carcinomas that acts on a class of G-protein This abundance is exploited for cancer imaging, but there is interest in pharmacological inhibition of In human breast tumor tissue, we show via immunofluorescence that NPY5R protein levels and colocalization with hypoxia correlate with advanced cancer, and NPY1R protein correlates with adverse outcomes.

Specifically, I am interested in understanding dysregulated G-protein coupled receptor (GPCR) signaling that serve as the gut microbial metabolite (PAG) receptor and characterized the receptor-metabolite interaction More recently, I have shifted my focus to identifying allosteric modulators of host G-protein-coupled

After 2-24 h, brains were collected for the analysis of gene expression by RT-PCR or protein expression and then with LPS (100 ng/ml) followed by 10 nM synaptamide for 2 h for gene expression and 12 h for protein GPR110 ligand decreased the mRNA and/or protein expression of these cytokines and Iba-1 in the WT but PDE4B expression at both mRNA and protein level in the brain increased after ethanol and LPS treatment

angiostatic activity Published date February 2, 2024 Abstract " Background: Interferon-γ-inducible protein dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupled receptor (GPCR), CXC chemokine receptor 3 (CXCR3). Methods: Relative levels of CXCL10(1-73) and intact CXCL10(1-77) were determined in synovial fluids of and through quantification of phosphorylated extracellular signal-regulated kinase-1/2 (ERK1/2) and protein

Domain in a Holo-Adhesion GPCR Demet Araç Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors Andrew Dates Discriminating between the extracellular scaffolding and G protein signaling In this ECR-mediated mechanism of activation, the ECR-7TM communication is altered by transient interactions Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins As an undergraduate, he studied opioid receptor trafficking and G protein conformational dynamics in

pathway of the ADGRA homolog Remoulade in Drosophila Beatriz Blanco Redondo The Adhesion GPCR Latrophilin Interacts Drosophila Beatriz Blanco Redondo Abstract "The Drosophila genome contains five loci encoding adhesion G-protein Remo homolog ADGRA2/Gpr124 cooperates with other GPCRs of the Frizzled family, and the transmembrane proteins Collectively these proteins form a cell surface complex that acts as a recognition platform for Wnt ligands Redondo on the web Blanco-Redondo Lab LinkedIn Google Scholar X (Twitter) The Adhesion GPCR Latrophilin Interacts

Following her postdoctoral studies on protein dynamics simulation methods at University of Southern California contributions in developing constrained molecular dynamics simulation methods with emphasis on application to G-protein

Sakmar’s laboratory at Rockefeller University, where she studies the signaling and degradation of G protein-coupled understand the signaling and degradation of GPCRs in disease states to help test the feasibility of using protein-targeted

by the tumor microenvironment Published date November 20, 2023 Abstract " Background: Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor (GPCR) signaling, is highly Huang , Yu Song , Wen-Di Zhang , Rui-Juan Guo , Han Li , Mei Han Tags Breast cancer , Regulator of G protein

Here we show that the G protein-coupled receptor (GPCR) to cAMP pathway is responsible for transmitting These studies highlight a crucial G protein signaling pathway for cell communication that is mediated Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication , G protein-coupled

In this study, we aimed to integrate the genetic alterations, protein expression profiles, transcriptomes Targeted capture sequencing and copy number analysis of 36 genes and nontargeted proteomics analysis between the proteome and the transcriptome. Gene ontology analysis was performed for differentially expressed proteins between wild-type and mutant GNAS samples identified by nontargeted proteomics and involved in G protein-coupled receptor (GPCR)

to Attain Trabecular Identity Andrew Dates Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled and neuroimmune alterations during neurodevelopment Rashed Rezwan Parag Novel isoforms of adhesion G protein Mating In The Closest Relatives Of Animals Anne Bormann Intricacies Of Complex Assembly And Ligand Interaction Deorphanization Of The Adhesion GPCRs GPR110 and GPR116 Willem Berend Post The Adhesion GPCR Latrophilin Interacts cardiac health and disease Frank Kwarcinski Discriminating between the extracellular scaffolding and G protein

Lab LinkedIn Characterization of Phenotypes Associated with GPR110 Deletion Hee-Yong Kim Abstract "G-protein Synaptamide, an endogenous ligand for GPR110, binds to the N-terminal G-protein autoproteolysis-inducing molecular basis for the renal phenotype, we analyzed in parallel differential expression of kidney proteins The change in protein expression of key proteins including VEGFA is associated with the abnormal renal I have a particular interest in understanding the premetazoan function of adhesion GPCRs."

Emerging GPCR targets for AUD: Insights from preclinical studies Published date July 5, 2024 Abstract "G protein-coupled GPCRs) are the largest group of membrane receptors in the central nervous system and one of the key proteins

rigorous mechanistic insights into the structure, dynamics, and function of important classes of membrane proteins and prominent drug targets, including G protein-coupled receptors (GPCRs), transporters, channels, and

Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins , academic backgrounds, and career paths, with a focus on their experiences in the field of GPCR (G protein-coupled developments in the GPCR field, the upcoming adhesion GPCR consortium meeting, and the naming conventions of proteins the field lacked adequate tools, and his lab had to develop new techniques to work with these complex proteins They also addressed the naming conventions of proteins in the field, with Yamina expressing concern about

Lauren Slosky About Irfan Dhanidina "My interest in oncology research led me to pursue a BSc in Biology With respect to GPCRs, I'm particularly interested in peptide/small protein receptors and the mechanisms With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular Slosky’s research is focused on understanding how neuropeptide G protein-coupled receptors (GPCRs) regulate These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling

Targeted Therapy Published date October 4, 2024 Abstract "Olfactory receptors (ORs) are a class of G protein-coupled Authors Yi Tang, Ye Tian, Chun-Xia Zhang, Guo-Tai Wang Tags G Protein-coupled receptors , Olfactory receptors

CXCL12-induced signaling and cell migration Published date September 25, 2023 Abstract "Background: G protein-coupled In our preliminary study, we identified LPA1 as a prospective CXCR4 interactor. functional implications of the CXCR4-LPA1 heteromer, we performed various assays, including cAMP, BRET for G protein , Dong-Seung Seen , Jae-Yeon Jeong , Won-Ki Huh Tags Cancer , Chemokine receptor 4 , Chemotaxis , G protein-coupled

G protein-coupled receptors (GPCRs) mediate a vast variety of critical biological processes and provide How can we best leverage these exciting new techniques in areas such as protein structure prediction,

Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially Switzerland, Department of Biochemistry (2005-2009), where I started working on membranes and membrane protein

Recently, his group reported the first in vivo GPCR interactome, revealing an important number of new potential proteins interacting with GPCRs.

Molecular Medicine and Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled Sakmar’s laboratory at The Rockefeller University, where she study’s the signaling and degradation of G protein-coupled understand the signaling and degradation of GPCRs in disease states to help test the feasibility of using protein-targeted

responses depends on orchestrated migration of B cells within lymphoid organs, which is governed by G protein-coupled Our recent study revealed that a protein complex consisting of copper metabolism MURR1 domain-containing

In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully coupled to either mini-Gs or mini-Go, and also by electron cryo-microscopy of receptors coupled to mini G protein

and cancers Published date March 15, 2023 Abstract " C-X-C motif chemokine receptor 2 (CXCR2) is G protein-coupled Hence, we provide an overview containing the discovery history, protein structure, signaling pathways

With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular