Search Results
215 items found for "Bcl-2"
- Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
protease-activated receptor 1 autoantibodies are associated with severe COVID-19 Published date December 27 , 2022 Abstract In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were
- GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
network and its dynamics in the mesenchymal transition of glioblastoma Published date November 19, 2023 is involved in the mesenchymal transition, making it a promising therapeutic target (Ganesh et al., 2022
- GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
pathway in glioblastoma activated by acidic extracellular microenvironment Published date January 31, 2024
- The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor
receptor 141 expressed in myeloid cells functions as an inflammation suppressor Published date April 29 , 2024 Abstract "G protein-coupled receptors (GPCRs) regulate many cellular processes in response to
- CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration
sensor and a sink for CCL19 to coordinate collective leukocyte migration Published date September 1, 2023
- Ep 31 with Dr. Kevin Pfleger
expertise in profiling receptor binding and function at the molecular and cellular levels over the last 20
- Ep 133 with Dr. Richard Premont
1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until 2018 In 2018, he moved to Harrington Discovery Institute and Case Western Reserve University, where he studies
- Lunch 1
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd
- Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy
Extracellular ATP and the tumor microenvironment in cancer progression and therapy Published date June 28 , 2024 Abstract "Adenosine 5'-triphosphate (ATP) is a vital element in energy information.
- Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
of G protein-coupled receptors and tumor microenvironment in melanoma Published date September 16, 2023
- Ep 85 with Nicholas Holliday
Nick joined the University of Nottingham in 2006, where he is now Associate Professor, establishing a Since 2019, Nick has combined his university role with the leadership of Excellerate Bioscience as Chief
- Illuminating Functional Selectivity and Allosterism at GPCRs.
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling Published date June 21 , 2024 Abstract "Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking
- Ep 142 with Dr Claudia Stäubert
Since 2014, I have led a research group at the Rudolf Schönheimer Institute of Biochemistry in Leipzig
- The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication
receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication Published date May 21 , 2024 Abstract " Objective: CCR5, a G protein-coupled receptor (GPCR), is used by most HIV strains as
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
ciliary regulation of hedgehog pathway repression in tissue morphogenesis Published date November 9, 2023
- Signaling by Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions
Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions Published date July 26 , 2024 Abstract "In human peripheral blood, the neutrophil granulocytes (neutrophils) are the most-abundant
- Ep 33 with Dr. David E. Gloriam
his Ph.D. from Uppsala University in Sweden where he worked on the bioinformatic identification of 24 In 2018 he joined the University of Copenhagen, where he has received an ERC Starting Grant, Lundbeck
- Ep 118 with Dr. David Sykes
David has over 20+ years of experience working in a drug discovery environment mainly in a specialist In 2014 David joined the University of Nottingham and began a part-time PhD in Molecular Pharmacology and Drug Discovery that he was awarded in 2020.
- Ep 104 with Dr. Raul Gainetdinov
-2016) and an Associate Research Professor in the Department of Cell Biology at Duke University in North Carolina, USA (1996-2008). From 2013-2018, he was also a Professor at the Skolkovo Institute of Science and Technology (Skoltech As of August 2022, he has over 270 publications in scientific journals (including Science, Nature, Cell His papers were cited over 28,000 times (H-index – 81, ISI Web of Science). In 2018-2020, Raul R.
- Ep 32 with Dr. Chris Tate
Chris also worked on the E. coli multidrug transporter EmrE and obtained both 2D and 3D crystals as well In 2005 he started working on the development of conformational thermostabilization of GPCRs, which resulted In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully
- GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment
the pH-dependent migration of melanoma cells in the tumor microenvironment Published date December 23 , 2022 Abstract Due to its high metastatic potential, malignant melanoma is one of the deadliest skin In this study, we investigated the pH-dependent migration of GPR4 wildtype/overexpressing SK-Mel-28 cells Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared
- Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody
pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody Published date September 21 , 2023 Abstract "Phosphatase of regenerating liver 3 (PRL3) is a specific tumor antigen overexpressed A 28.6% reduction in maximum target lesion diameter was achieved when PRL3-zumab was administered concurrently
- G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells
protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells Published date January 10, 2024
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
GPCR signaling reveals unexpected differences in downstream pathway activation Published date July 16, 2024
- Deciphering the genetic landscape of lumpy skin disease: Unraveling variable virulence through comprehensive genome sequence analysis in India
Unraveling variable virulence through comprehensive genome sequence analysis in India Published date May 23 , 2024 Abstract "Lumpy Skin Disease (LSD), a poxvirus disease affecting cattle, emerged in India in 2019 and intensified in 2022, resulting in significant economic losses for dairy farmers. A comprehensive genetic study conducted, analyzing samples from 2019 to 2022 revealed circulation of outbreaks, absent in 2019 samples.
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
signaling axis promotes T cell dysfunction and cancer immunotherapy failure Published date June 12, 2023 druggable immune checkpoints that might be targeted to enhance the response to ICB immunotherapies. © 2023
- Ep 65 with Dr. Sudarshan Rajagopal
He was awarded his Ph.D. in 2004 and his MD in 2006.